39 hasil untuk "Hui Che"
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Artikel Jurnal
Lipid metabolism and osteonecrosis: unraveling causal mechanisms via multi-omics and mendelian randomization
Osteonecrosis (ON), a debilitating condition marked by ischemic bone death, has been clinically linked to dysregulated lipid metabolism, yet the causal relationships and underlying genetic mechanisms remain poorly defined. This study employed bidirectional Mendelian randomization (MR) analyses…
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Artikel Jurnal
Effects of copper-containing intrauterine devices on the endometrium
The use of copper-containing intrauterine devices (Cu-IUDs) is a safe, effective, and long-term contraceptive method. Here, we review the effects of Cu-IUDs on subsequent pregnancy and the morphology, local coagulation function, sensitivity to estrogen and progesterone, cell proliferation, and…
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Artikel Jurnal
Multicarrier Faster-Than-Nyquist Based on Efficient Implementation and Probabilistic Shaping
The conventional multicarrier faster-than-Nyquist (MFTN) achieves the spectral efficiency (SE) gain by deep compression. However, deep compression leads to severe intersymbol interference (ISI) or intercarrier interference (ICI). We propose the MFTN based on efficient implementation and…
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Artikel Jurnal
Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus that can cause malignant arrhythmia and sudden death and is associated with cardiomyocyte dysfunction induced by hyperglycemia. Emerging evidence has revealed that transfer RNA-derived fragments (tRFs), a novel class of…
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Artikel Jurnal Teks lengkap
Immune Cell Causality and Glucocorticoid Trade-Off in Frozen Shoulder: Integrative MR-RNA-Seq Analysis
Objectives: Frozen shoulder (FS) is characterized by chronic inflammation and fibrosis of the joint capsule, yet the causal roles of immune cell subtypes remain unclear. This study aimed to identify immune cell traits causally associated with FS and evaluate the potential impact of glucocorticoids…
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Artikel Jurnal Teks lengkap
Effects of BK Ca and Kir2.1 Channels on Cell Cycling Progression and Migration in Human Cardiac c-kit + Progenitor Cells
Our previous study demonstrated that a large-conductance Ca2+-activated K+ current (BKCa), a voltage-gated TTX-sensitive sodium current (INa.TTX), and an inward rectifier K+ current (IKir) were heterogeneously present in most of human cardiac c-kit+ progenitor cells. The present study was designed…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Biopsychosocial factors associated with symptom severity in the overlap of non-erosive reflux disease and epigastric pain syndrome: A multicenter cross-sectional study
Background: The overlap between non-erosive reflux disease (NERD) and epigastric pain syndrome (EPS, a subtype of functional dyspepsia) is common, yet its associated factors remain poorly defined. We aimed to identify factors associated with symptom severity in NERD-EPS overlap, focusing on…
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Artikel Jurnal
Harmine Ameliorates Cognitive Impairment by Inhibiting NLRP3 Inflammasome Activation and Enhancing the BDNF/TrkB Signaling Pathway in STZ-Induced Diabetic Rats
Diabetes mellitus (DM) is considered a risk factor for cognitive dysfunction. Harmine not only effectively improves the symptoms of DM but also provides neuroprotective effects in central nervous system diseases. However, whether harmine has an effect on diabetes-induced cognitive dysfunction and…
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Artikel Jurnal
Diffusion Tensor Imaging With Tract-Based Spatial Statistics Reveals White Matter Abnormalities in Patients With Vascular Cognitive Impairment
Purpose: The aim of this study was to evaluate microstructural changes of major white matter (WM) tracts in patients with vascular cognitive impairment (VCI).Method: Diffusion tensor imaging (DTI) data were obtained from 24 subjects with subcortical ischemic vascular disease (SIVD), including 13…
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Artikel Jurnal
Novel Intronic Mutations of TBK1 Promote Aberrant Splicing Modes in Amyotrophic Lateral Sclerosis
TANK-binding kinase 1 (TBK1) has been identified as a causative gene of amyotrophic lateral sclerosis (ALS) in the Caucasian population in 2015. Here, we sequenced for TBK1 variants in a cohort of 15 familial ALS (fALS) and 275 sporadic ALS (sALS) of Chinese origin by targeted next-generation…
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Artikel Jurnal
A Novel Method for Preoperative Positioning of Total Ankle Replacement Using 3D Digital Model
Abstract Objective To establish a digital model of the ankle joint through 3D imaging technology and explore the preoperative placement of ankle replacement prostheses. Methods Computed tomography images of intact ankle joints from 54 cases in the outpatient and inpatient departments of our…
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Artikel Jurnal
Genetic insights into serum cathepsins as diagnostic and therapeutic targets in knee and hip osteoarthritis
Abstract Osteoarthritis (OA) is a chronic disease due to the deterioration of cartilage structure and function, involving the progressive degradation of the cartilage extracellular matrix. Cathepsins, lysosomal cysteine proteases, play pivotal roles in various biological and pathological processes…
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Artikel Jurnal Teks lengkap
A retrospective analysis of e-prescriptions for non-communicable diseases on a telehealth platform in Malaysia
BACKGROUND: The management of non-communicable diseases (NCDs) has benefited from telehealth services. As these services which include teleconsultation services and e-prescriptions are relatively new in Malaysia, the data generated provide an unprecedented opportunity to study medication use…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Exploring the rise of telehealth services in Malaysia: A retrospective study
BACKGROUND: Telehealth services have gained popularity in Malaysia, providing convenient consultations during the COVID-19 pandemic. However, there is limited research on their usage, user demographics and prescribed medications. This study aims to fill that gap by investigating telehealth service…
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Preprint Teks lengkap
OVGGT: O(1) Constant-Cost Streaming Visual Geometry Transformer
Reconstructing 3D geometry from streaming video requires continuous inference under bounded resources. Recent geometric foundation models achieve impressive reconstruction quality through all-to-all attention, yet their quadratic cost confines them to short, offline sequences. Causal-attention…
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Artikel Jurnal
The effect of allyl isothiocyanate on chondrocyte phenotype is matrix stiffness-dependent: Possible involvement of TRPA1 activation
Osteoarthritis (OA) is a chronic joint disease with increasing prevalence. Chondrocytes (CHs) are highly differentiated end-stage cells with a secretory phenotype that keeps the extracellular matrix (ECM) balanced and the cartilage environment stable. Osteoarthritis dedifferentiation causes…