12 hasil untuk "Li-Mei Liang"
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Artikel Jurnal
Causal association between peripheral immune cells and IgA nephropathy: a Mendelian randomization study
BackgroundThe relationship between peripheral immune cells and immunoglobulin A nephropathy (IgAN) is widely known; however, causal evidence of this link is lacking. Here, we aimed to determine the causal effect of peripheral immune cells, specifically total white blood cells, lymphocytes…
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Artikel Jurnal
Wuzang Wenyang Huayu Tang Treatment of vascular dementia by modulation of BCL-2/BAX/Caspase3: An integrated in vitro cellular assay and network pharmacological analysis
Objective: This project explores Wuzang Wenyang Huayu Tang (WWHT) 's potential mechanisms for treating vascular dementia (VD) based on network pharmacology and experimental validation. Methods: TCMSP was used to screen the active ingredients and targets of WWHT; GeneCards was used to identify…
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Artikel Jurnal
Bidirectional association between zinc and liver cirrhosis: evidence from mendelian randomization and clinical validation
BackgroundIt remains unclear whether low blood zinc levels in cirrhosis patients are a cause or a consequence of the disease.MethodsSeven blood metals (calcium, iron, magnesium, phosphorus, copper, selenium, zinc) were assessed using two-sample Mendelian randomization (MR). We performed reverse MR…
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Artikel Jurnal
Splicing factor SRSF6 mediates pleural fibrosis
Pleural fibrosis is defined as an excessive deposition of extracellular matrix that results in destruction of the normal pleural tissue architecture and compromised function. Tuberculous pleurisy, asbestos injury, and rheumatoid pleurisy are main causes of pleural fibrosis. Pleural mesothelial…
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Artikel Jurnal Teks lengkap
Inhibition of Matrix Metalloproteinase-7 Attenuates Subpleural Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease
Background: Rheumatoid arthritis-related interstitial lung disease (RA-ILD) is a significant complication of RA which lacks effective treatments with high mortality. This study aimed to investigate the role of matrix metalloproteinase-7 (MMP-7) in mediating RA-ILD. Methods: Based on the database of…
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Artikel Jurnal
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis
Abstract Background The alveolar epithelial type II cell (AT2) and its senescence play a pivotal role in alveolar damage and pulmonary fibrosis. Cell circadian rhythm is strongly associated with cell senescence. Differentiated embryonic chondrocyte expressed gene 1 (DEC1) is a very important…
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Artikel Jurnal
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness
The interaction between cells and extracellular matrix (ECM) has been recognized in the mechanism of fibrotic diseases. Collagen type VII (collagen VII) is an ECM component that plays an important role in cell-ECM interaction, particularly in cell anchoring and maintenance of ECM integrity. Pleural…
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Artikel Jurnal
IL-10 mediates pleural remodeling in systemic lupus erythematosus
Abstract Background Interleukin-10 (IL-10), a pivotal anti-inflammatory cytokine, has gotten attention for its involvement in tissue remodeling and organ fibrosis. Pleurisy and subsequent pleural remodeling are recognized as quantifiable indicators of systemic lupus erythematosus (SLE) activity…
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Artikel Jurnal
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma
Abstract Background Fine particulate matter (PM2.5) is associated with increased incidence and severity of asthma. PM2.5 exposure disrupts airway epithelial cells, which elicits and sustains PM2.5-induced airway inflammation and remodeling. However, the mechanisms underlying development and…
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Artikel Jurnal
Versican regulating viscoelasticity drives pleural fibrosis via mechanotransductive signaling
Extracellular matrix (ECM) disorder was believed to result from fibrosis, but it has recently been recognized that fibrotic ECM initiates a self-reinforcing circuit and contributes to the development of fibrosis. Versican, an ECM component, participates in cell-ECM interaction and ECM regeneration…
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Artikel Jurnal
Upregulated CCN1 from pleural mesothelial cells alters collagen I conformation and drives fibrosis via ITGB1/MAPK signaling
Abstract Background Pleural mesothelial cells (PMCs) have been identified as key contributors to pleural fibrosis. Cellular communication network factor 1 (CCN1), a matricellular protein, regulates cell–matrix interactions and fibrotic signaling in multiple contexts. However, the specific role and…
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Artikel Jurnal
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis
Abstract Tuberculosis pleural effusion (TPE) accounts for 30 ~ 80% of all pleural effusions in developing countries and remains a major contributor to global morbidity and mortality. Although TPE is often absorbed after anti-tuberculosis treatment, approximately 60% of patients develop pleural…