15 hasil untuk "Lihao Lin"
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Artikel Jurnal
Decoding iron deficiency in cancer: mechanisms, immune modulation, and therapeutic potential
Iron is a vital micronutrient in many biological functions, including DNA metabolism, oxygen transport, and cellular energy generation. In this context, it is intimately linked to cancer biology. However, although many studies have comprehensively investigated and reviewed the effects of excess…
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Artikel Jurnal Teks lengkap
Mechanistically informed machine learning links non-canonical TCA cycle activity to Warburg metabolism and hallmarks of malignancy
Cancer cells undergo extensive metabolic rewiring to support growth, survival, and phenotypic plasticity. A non-canonical variant of the tricarboxylic acid (TCA) cycle, characterized by mitochondrial-to-cytosolic citrate export, has emerged as critical for embryonic stem cell differentiation…
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Artikel Jurnal
Genetic association of type 2 diabetes mellitus and glycaemic factors with primary tumours of the central nervous system
Abstract Type 2 diabetes mellitus (T2DM) is a pivotal chronic disease with an increasing prevalence. Recent studies have found associations between T2DM and the development of central nervous system (CNS) tumours, a special class of solid tumours with an unclear pathogenesis. In this study, we…
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Artikel Jurnal
A novel near-infrared II viscosity-responsive probe for surgical fluorescence guidance: laboratory investigation in a murine subcutaneous glioma model
Distinguishing brain tumor boundaries from surrounding parenchymal tissue with high sensitivity and specificity remains a daunting clinical challenge due to their diffuse nature and proximity to critical brain regions. Currently approved clinical fluorescent contrast agents are insufficient for…
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Artikel Jurnal
Multi-omics and Mendelian randomization study explores potential therapeutic targets for meningiomas
Abstract Background Meningioma is a common primary central nervous system tumor that can cause a heavy burden on patients. Despite its well-established treatment modalities, pharmacological treatments are not sufficiently abundant. Therefore, we explored potential therapeutic targets for…
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Artikel Jurnal
Complete excision of a giant chondrosarcoma within the cavernous sinus: a case report and literature review
Abstract Background Primary skull base chondrosarcoma (SBC) is a rare malignant central nervous system tumor, often involving the cavernous sinus. Complete excision of tumors invading this region is exceptionally challenging due to the presence of the internal carotid artery and numerous nerves…
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Artikel Jurnal
Influence of Hydrogen Content on the Microstructure and Mechanical Properties of ER5183 Wires
This work focused on the influence of hydrogen content on the microstructure and mechanical properties of ER5183 Al-Mg-Mn alloy wires for aluminum alloy welding. The hydrogen content of the ER5183 wires was measured, the macroscopic and microscopic morphologies of fractures were observed as well as…
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Artikel Jurnal
Comparative inhibitory effects of phillyrin and phillygenin on elastase: mechanisms and therapeutic potential
Elastase, a serine protease, has been implicated in chronic obstructive pulmonary disease and systemic inflammatory response syndrome. In this study, we evaluated the effects of phillyrin and phillygenin, 2 major Forsythia lignans, on elastase inhibition. Both compounds exhibited competitive…
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Artikel Jurnal
Exosome-delivered miR-153 from Trichinella spiralis promotes apoptosis of intestinal epithelial cells by downregulating Bcl2
Abstract Trichinellosis, a helminthic zoonosis, exhibits a cosmopolitan distribution and is a public health concern. In previous studies, it was reported that the exosomes secreted by Trichinella spiralis larvae (TsExos) largely affected cell biological activities. miRNAs, as exosome-delivered…
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Artikel Jurnal
Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function
Abstract Muscle larvae of Trichinella spiralis parasitize the host intestinal epithelium. The mechanisms of exosomes participating in the invasion of T. spiralis muscle larvae are unclear. Hence, the purpose of this study was to explore the effect of exosomes derived from T. spiralis infective…
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Artikel Jurnal
Elastase inhibition by natural flavonoids: mechanistic insights and potential therapeutic applications
Overproduction of elastase plays an important role in the progression of inflammatory diseases. In this study, we compared the inhibitory effects of structurally similar bioactive flavonoids (quercetin, hyperoside, luteolin, and luteoloside) on elastase activity and elucidated their mechanisms of…
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Artikel Jurnal
Regulatory effects of Trichinella spiralis and a serine protease inhibitor on the endoplasmic reticulum stress response of intestinal epithelial cells
Abstract The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum can cause an endoplasmic reticulum stress (ERS) response. If ERS continues or cannot be alleviated, it will cause the production of proapoptotic factors and eventually lead to apoptosis. Therefore, this study…
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Artikel Jurnal
Regulatory effects of Trichinella spiralis serpin-type serine protease inhibitor on endoplasmic reticulum stress and oxidative stress in host intestinal epithelial cells
Abstract Endoplasmic reticulum stress (ERS) and oxidative stress (OS) are adaptive responses of the body to stressor stimulation. Although it has been verified that Trichinella spiralis (T. spiralis) can induce ERS and OS in the host, their association is still unclear. Therefore, this study…
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Artikel Jurnal
Evolutionary insights and structural characterization guide the development of RAG1/RAG2-deficient swine models for immunological research
IntroductionDefects in RAG1/RAG2-mediated V(D)J recombination cause severe combined immunodeficiency (SCID), a disorder characterized by the absence of mature T and B lymphocytes resulting from impaired antigen receptor gene rearrangement. Although evolutionary analyses demonstrate strong…