21 hasil untuk "Lin-Shien Fu"

Asthma Exacerbation in Children: A Practical Review

Lin-Shien Fu; Ming-Chin Tsai

Pediatrics and Neonatology, Vol. 55 No. 2 · 2014 · Inggris · DOAJ Scopus

Asthma is the most common chronic lower respiratory tract disease in childhood throughout the world. Despite advances in asthma management, acute exacerbations continue to be a major problem in patients and they result in a considerable burden on direct/indirect health care providers. A severe…

Remission and long-term remission of pediatric-onset systemic lupus erythematosus

Yi-Chieh Chen; Chiann-Yi Hsu; Ming-Chin Tsai dkk.

Frontiers in Pediatrics, Vol. 11 · 2023 · Inggris · DOAJ Scopus

ObjectivesSystemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations and prognoses. Remission can be achieved with or without glucocorticoid (GC) use, and several recent studies have suggested that long-term remission can be achieved in a small portion of…

A Novel BTK Gene Mutation in a Child With Atypical X-Linked Agammaglobulinemia and Recurrent Hemophagocytosis: A Case Report

Shu-Ping Han; Yung-Feng Lin; Hui-Ying Weng dkk.

Frontiers in Immunology, Vol. 10 · 2019 · Inggris · DOAJ Scopus

X-linked agammaglobulinemia (XLA), caused by a mutation in the Bruton's tyrosine kinase (BTK) gene, is rarely reported in patients with recurrent hemophagocytic lymphohistiocytosis (HLH). This mutation leads to significantly reduced numbers of circulatory B cells and serum immunoglobulins in…

Risk of developing juvenile idiopathic arthritis after quadrivalent HPV vaccination: a retrospective cohort study using the TriNetX U.S. Network

Wen-Yu Wu; Hsin-Hua Chen; Ming-Chin Tsai dkk.

Frontiers in Immunology, Vol. 16 · 2025 · Inggris · DOAJ Scopus

IntroductionHuman papillomavirus (HPV) infection has been implicated in autoimmune processes, yet concerns remain about the potential autoimmune risks of HPV vaccination. Juvenile idiopathic arthritis (JIA) is a chronic autoimmune condition that typically manifests in childhood. The relationship…

Allergic children with extremely high total IgE but no allergen identified in the initial screening panel

I-Hui Lin; Ming-Chin Tsai; Jun-Peng Chen dkk.

Journal of Microbiology, Immunology and Infection, Vol. 54 No. 3 · 2021 · Inggris · DOAJ Scopus

Background: High serum IgE level in atopic children usually implies a highly sensitized condition. However, there is a subgroup of atopic children for whom a specific allergen cannot be identified. In this study, we analyzed follow-up data from these children. Methods: From March 2014 to July 2017…

Systemic lupus erythematosus and thyroid disease – Experience in a single medical center in Taiwan

Yu-chuan Liu; Wen-ya Lin; Ming-chin Tsai dkk.

Journal of Microbiology, Immunology and Infection, Vol. 52 No. 3 · 2019 · Inggris · DOAJ Scopus

Background: To investigate the association of systemic lupus erythematosus (SLE) with thyroid diseases in a medical center in central Taiwan. Methods: This is a retrospective cohort of 2796 SLE patients in a tertiary referral medical center from 2000 to 2013. We screened SLE by catastrophic illness…

Frasier Syndrome: A Rare Cause of Refractory Steroid-Resistant Nephrotic Syndrome

Yung-Chieh Huang; Ming-Chin Tsai; Chi-Ren Tsai dkk.

Children, Vol. 8 No. 8 · 2021 · Inggris · DOAJ Scopus

Frasier syndrome is a rare disease that affects the kidneys and genitalia. Patients who have Frasier syndrome develop nephrotic syndrome (NS) featuring focal segmental glomerulosclerosis (FSGS) that is resistant to steroid treatment in early childhood. Male patients can have female external…

Risk of acute exacerbation between acetaminophen and ibuprofen in children with asthma

Lin-Shien Fu; Che-Chen Lin; Chia-Yi Wei dkk.

PeerJ, Vol. 7 · 2019 · Inggris · DOAJ Scopus

Background Antipyretics are widely prescribed in pediatric practice. Some reports have mentioned that acetaminophen and non-steroid anti-inflammatory drugs may negatively affect asthma control by causing asthma exacerbation (AE). However, many confounding factors can also influence the risks. We…

Association between dry eye disease and asthma: a nationwide population-based study

Yung-Chieh Huang; Wei-Cheng Chan; Jiaan-Der Wang dkk.

PeerJ, Vol. 6 · 2018 · Inggris · DOAJ Scopus

Background Dry eye disease (DED), a chronic ocular disease, is associated with numerous medical issues, including asthma. However, studies on these associations are limited. In this study, we investigated the incidence of DED among patients with asthma and its correlation with other allergic…

Impact of antipyretics on acute asthma exacerbation during respiratory infection—A nationwide population-based study

Ruei-Sian Chung; Yung-Chieh Huang; Yi-Huei Chen dkk.

Pediatrics and Neonatology, Vol. 61 No. 5 · 2020 · Inggris · DOAJ Scopus

Background: Antipyretics are frequently used in pediatric practice. Both acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to increase the risk of asthma exacerbation. The study investigated antipyretic use during respiratory infection in children and analyzed the…

Evaluation of the Effect of Lactobacillus paracasei (HF.A00232) in Children (6–13 years old) with Perennial Allergic Rhinitis: A 12-week, Double-blind, Randomized, Placebo-controlled Study

Wen-Ya Lin; Lin-Shien Fu; Heng-Kuei Lin dkk.

Pediatrics and Neonatology, Vol. 55 No. 3 · 2014 · Inggris · DOAJ Scopus

Dietary supplementation with probiotics alters intestinal microflora of children and may have immunomodulatory effects in prevention of allergic diseases. The aim of this study was to evaluate the effects of Lactobacillus paracasei (LP), strain HF.A00232, as a supplementary agent to levocetirizine…

The correlation between trajectories of serum C3 variability and clinical course in Pediatric-onset systemic lupus erythematosus

Yun-chuan Chen; Yung-chieh Huang; Jun-peng Chen dkk.

Journal of Microbiology, Immunology and Infection, Vol. 56 No. 5 · 2023 · Inggris · DOAJ Scopus

Objective: The aim of this study is to investigate the usefulness which 2-year trajectories of C3 variability have in predicting clinical remission and systemic corticosteroids (SCS) use in pediatric patients with systemic lupus erythematosus (pSLE). Methods: We recruited 189 confirmed pSLE…

Automatic Screening of Pediatric Renal Ultrasound Abnormalities: Deep Learning and Transfer Learning Approach

Ming-Chin Tsai; Henry Horng-Shing Lu; Yueh-Chuan Chang dkk.

JMIR Medical Informatics, Vol. 10 No. 11 · 2022 · Inggris · DOAJ Scopus

BackgroundIn recent years, the progress and generalization surrounding portable ultrasonic probes has made ultrasound (US) a useful tool for physicians when making a diagnosis. With the advent of machine learning and deep learning, the development of a computer-aided diagnostic system for screening…

Influential Factors of Insufficient Physical Activity among Adolescents with Asthma in Taiwan

Yu-Kuei Teng; Jing-Long Huang; Kuo-Wei Yeh dkk.

PLoS ONE, Vol. 9 No. 12 · 2014 · Inggris · PLOS Scopus

Purpose: Little research has been reported concerning insufficient physical activity in Taiwanese adolescents with asthma. The aims of this paper are to compare the amount of physical activity between asthmatic and non-asthmatic adolescents in Taiwan, as well as to investigate the influential…

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Association of 9-Valent HPV Vaccination with Risk of Juvenile Idiopathic Arthritis: A Sex-Stratified Real-World Study

Yi-Sin Liou; Lin-Shien Fu; Hsin-Hua Chen dkk.

Vaccines, Vol. 14 No. 9 · 2026 · Inggris · DOAJ Scopus

Objective: To evaluate the association between 9-valent human papillomavirus (HPV9) vaccination and the risk of new-onset juvenile idiopathic arthritis (JIA), with particular attention to sex-specific differences, including the relative lack of evidence in males and the potential impact of the…

Risk of Juvenile Idiopathic Arthritis Following HPV9 Vaccination: A Retrospective Cohort Study Before and During the COVID-19 Pandemic

Ming-Chin Tsai, MD; Hsin-Hua Chen, MD, PhD; Wen-Yu Wu, MD dkk.

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol. 9 No. 5 · 2025 · Inggris · DOAJ Scopus

Objective: To evaluate whether 9-valent human papillomavirus (HPV9) vaccination is associated with an increased risk of juvenile idiopathic arthritis (JIA), particularly during the coronavirus disease-2019 (COVID-19) pandemic. Patients and Methods: We conducted a retrospective cohort study using…

Liver Cancer Detection by a Simple, Inexpensive and Effective Immunosensor with Zinc Oxide Nanoparticles

Congo Tak-Shing Ching; Nguyen van Hieu; Teng-Yun Cheng dkk.

Sensors, Vol. 15 No. 11 · 2015 · Inggris · DOAJ Scopus

Regular monitoring of blood α-fetoprotein (AFP) and/or carcino-embryonic antigen (CEA) levels is important for the routine screening of liver cancer. However, AFP and CEA have a much lower specificity than des-γ-carboxyprothrombin (DCP) to detect liver cancer. Therefore, the study reported here was…

Low-Molecular-Weight Heparin and Unfractionated Heparin Decrease Th-1, 2, and 17 Expressions

Jing-Ning Huang; Ming-Chin Tsai; Shun-Lung Fang dkk.

PLoS ONE, Vol. 9 No. 11 · 2014 · Inggris · PLOS Scopus

Background: We evaluated the effects of T helper cell differentiation in a mite-allergic animal model treated with inhaled heparins of different molecular weight. Method: BALB/c mice were divided into four groups: 1. Control, 2. Mite intratracheal (mIT), 3. Inhaled heparin (hIN), 4. Inhaled…

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