14 results for "Linbin Lu"

Hepatic Resection Versus Transarterial Chemoembolization for Intermediate-Stage Hepatocellular Carcinoma: A Cohort Study

Linbin Lu; Peichan Zheng; Zhixian Wu et al.

Frontiers in Oncology, Vol. 11 · 2021 · English · DOAJ Scopus

BackgroundThe selection criteria for hepatic resection (HR) in intermediate-stage (IM) hepatocellular carcinoma (HCC) are still controversial. We used real-world data to evaluate the overall survival (OS) in treatment with HR or transarterial chemoembolization (TACE).MethodsIn total, 942 patients…

Correction: Fatal adverse events associated with programmed cell death ligand 1 inhibitors: a systematic review and meta-analysis

Xuewen Wang; Shijie Wu; Yaying Chen et al.

Frontiers in Pharmacology, Vol. 17 · 2026 · English · DOAJ Scopus

Fatal Adverse Events Associated With Programmed Cell Death Ligand 1 Inhibitors: A Systematic Review and Meta-Analysis

Xuewen Wang; Shijie Wu; Yaying Chen et al.

Frontiers in Pharmacology, Vol. 11 · 2020 · English · DOAJ Scopus

PurposeWe performed this systematic review and meta-analysis to assess the incidence of fatal adverse events that were associated with the use of programmed cell death ligand 1 (PD-L1) inhibitors, to describe them and to statistically depict factors that were associated with these…

Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study

Linbin Lu; Tingting Zhuang; Erqian Shao et al.

PLOS ONE, Vol. 14 No. 9 · 2019 · English · PLOS Scopus

Background: Preclinical studies showed that antibiotic exposure played a role in clinical outcomes in patients with chemotherapy via modulation of microbiota. However, it remains unknown whether antibiotic exposure during the bevacizumab therapy affects the clinical outcomes in metastatic…

Also available at: DOAJ

Trajectories of serum α-fetoprotein and intermediate-stage hepatocellular carcinoma outcomes after transarterial chemoembolization: A longitudinal, retrospective, multicentre, cohort study

Linbin Lu; Lujun Shen; Zhixian Wu et al.

EClinicalMedicine, Vol. 47 · 2022 · English · DOAJ Scopus

Summary: Background: α-fetoprotein (AFP) response has been proven a key tumor marker for hepatocellular carcinoma (HCC), but its definition remains controversial. This study aims to characterize AFP trajectories after transarterial chemoembolization (TACE) and examine its impact on clinical…

Clinical models to predict lymph nodes metastasis and distant metastasis in newly diagnosed early esophageal cancer patients: A population‐based study

Hong Chen; Junxian Wu; Wanting Guo et al.

Cancer Medicine, Vol. 12 No. 5 · 2023 · English · DOAJ Scopus

Abstract Background Patients with early esophageal cancer (EC) receive individualized therapy based on their lymph node metastasis (LNM) and distant metastasis (DM) status; however, deficiencies in current clinical staging techniques and the issue of cost‐effectiveness mean LNM and DM often go…

Association between platelet count and hepatocellular carcinoma overall survival: a large retrospective cohort study

Yan Zhang; Xiong Chen; Jingnan Liu et al.

BMJ Open, Vol. 10 No. 11 · 2020 · English · DOAJ Scopus

Objectives To explore the non-linear relationship between platelet count (PLT) and hepatocellular carcinoma (HCC) overall survival (OS).Setting The study was done in Sun Yat-sen University Cancer Center (SYSUCC) from January 2007 to May 2012, a total of 5005 consecutive participants at SYSUCC were…

A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer

Xianchun Gao; Zhe Li; Jun Yu et al.

Cancer Biology & Medicine, Vol. 23 No. 9 · 2026 · English · DOAJ Scopus

Development and validation of serological dynamic risk score to predict outcome in gastric cancer with adjuvant chemotherapy: a multicentre, longitudinal, cohort study

Linbin Lu; Wenzheng Fang; Jun Yu et al.

Frontiers in Oncology, Vol. 14 · 2024 · English · DOAJ Scopus

BackgroundBaseline serological biomarkers have the potential to predict the benefits of adjuvant chemotherapy in patients with gastric cancer. However, the fluctuating nature of postoperative recurrence risk makes precise treatment challenging. We aimed to develop a risk score in real-time…

Case report: Long response to PD-1 blockade after failure of trastuzumab plus chemotherapy in advanced Epstein-Barr virus-associated gastric cancer

Yan Pan; Linbin Lu; Huan Liu et al.

Frontiers in Immunology, Vol. 13 · 2022 · English · DOAJ Scopus

BackgroundTrastuzumab-containing chemotherapy is the first-line treatment for advanced gastric cancer (GC) with HER2 positive. Although PD-1 inhibitors significantly improved the outcome of GC patient’s refractory to previous chemotherapy regimens, few studies explore the role of anti-PD-1 therapy…

Deep learning for predicting lymph node metastasis in T1b gastric cancer using histopathology: a retrospective, multicenter study

Linbin Lu; Jun Yu; Yan Zhang et al.

Medicine Plus, Vol. 3 No. 2 · 2026 · English · DOAJ Scopus

Background: T1b gastric cancer (T1b-GC) carries a high risk of lymph node metastasis (LNM), which is a key determinant of treatment choice and prognosis. However, assessing LNM risk in T1b-GC remains challenging. This study aimed to develop machine learning models that integrate clinical data and…

DNA damage response-related immune activation signature predicts the response to immune checkpoint inhibitors: from gastrointestinal cancer analysis to pan-cancer validation

Junya Yan; Shibo Wang; Jing Zhang et al.

Cancer Biology & Medicine, Vol. 21 No. 3 · 2024 · English · DOAJ Scopus

Objective: DNA damage response (DDR) deficiency has emerged as a prominent determinant of tumor immunogenicity. This study aimed to construct a DDR-related immune activation (DRIA) signature and evaluate the predictive accuracy of the DRIA signature for response to immune checkpoint inhibitor (ICI)…

Association of survival with adjuvant chemotherapy in patients with stage IB gastric cancer: a multicentre, observational, cohort studyResearch in context

Xianchun Gao; Gang Li; Jingyu Deng et al.

The Lancet Regional Health. Western Pacific, Vol. 45 · 2024 · English · DOAJ Scopus

Summary: Background: Recurrence following radical resection in patients with stage IB gastric cancer (GC) is not uncommon. However, whether postoperative adjuvant chemotherapy could reduce the risk of recurrence in stage IB GC remains contentious. Methods: We collected data on 2110 consecutive…