13 hasil untuk "Meichen Yu"
Menampilkan 1–13 · 0,74 detik · RSS
-
Artikel Jurnal Teks lengkap
The human connectome in Alzheimer disease — relationship to biomarkers and genetics
-
Artikel Jurnal
Sotagliflozin versus dapagliflozin to improve outcome of patients with diabetes and worsening heart failure: a cost per outcome analysis
Background and aim:Dapagliflozin inhibits the sodium-glucose cotransporter protein 2 (SGLT-2), while sotagliflozin, belonging to a new class of dual-acting SGLT-1/SGLT-2 inhibitors, has garnered considerable attention due to its efficacy and safety. Both Dapagliflozin and sotagliflozin play a…
-
Artikel Jurnal Teks lengkap
Community Diversity of Fungi Carried by Four Common Woodpeckers in Heilongjiang Province, China
Woodpeckers exhibit selectivity when choosing tree cavities for nest development in forest ecosystems, and fungi play a significant and important role in this ecological process. Therefore, there is a complex and intricate relationship between the various behaviors of woodpeckers and the occurrence…
-
Artikel Jurnal
The complete mitochondrial genome and phylogenetic analysis of Rhinolophus pearsonii (Chiroptera: Rhinolophidae)
Rhinolophus pearsonii, widely distributed in the valleys of India and southern China. The mitochondrial DNA of R. pearsonii is packaged in a compact 16,900-basepair (bp) circular molecule with A + T content of 55.9%. It contains 37 typical mitochondrial genes, including 13 protein-coding genes, 2…
-
Artikel Jurnal
Characterization of the complete mitochondrial genome of the Lesser Spotted Woodpecker (Dryobates minor) and its phylogenetic position
In this study, we sequenced and assembled the complete mitochondrial genome of Dryobates minor by next-generation sequencing. The mitochondrial genome of Dryobates minor is 16,847 bp in length and consists of 13 protein-coding genes (PCGS), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA)…
-
Artikel Jurnal
Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders
Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with…
-
Artikel Jurnal
TrimNN: characterizing cellular community motifs for studying multicellular topological organization in complex tissues
Abstract The spatial organization of cells plays a pivotal role in shaping tissue functions and phenotypes in various biological systems and diseased microenvironments. However, the topological principles governing interactions among cell types within spatial patterns remain poorly understood…
-
Artikel Jurnal
Multidimensional niche advantages reveal how the red fox stands out in mesopredator release within terrestrial island habitats
Global pressures such as climate change and habitat fragmentation have altered apex predator population sizes, spatial distributions, and trophic interactions. Consequently, this has triggered fluctuations and even restructuring of mesopredator populations. During the decades of lack of apex…
-
Artikel Jurnal
Image harmonization: A review of statistical and deep learning methods for removing batch effects and evaluation metrics for effective harmonization
Magnetic resonance imaging and computed tomography from multiple batches (e.g. sites, scanners, datasets, etc.) are increasingly used alongside complex downstream analyses to obtain new insights into the human brain. However, significant confounding due to batch-related technical variation, called…
-
Artikel Jurnal
Network clustering algorithms and preprocessing pipelines for robust cell type identification in single-cell RNA sequencing data
Abstract Single cell RNA-seq (scRNA-seq) technologies provide unprecedented resolution representing transcriptomics at the level of single cell. One of the biggest challenges in scRNA-seq data analysis is the cell type annotation, which is usually inferred by cell separation approaches. In-silico…
-
Artikel Jurnal
Multi-omics integration study of vascular smooth muscle cell phenotypic conversion identified novel biomarkers in idiopathic pulmonary arterial hypertension
Abstract Background Idiopathic pulmonary arterial hypertension (IPAH) is a progressive, high‑mortality disease driven in part by maladaptive vascular remodeling. Phenotypic conversion of vascular smooth muscle cells (VSMCs) is implicated in this process, but the cellular heterogeneity and…
-
Artikel Jurnal
Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s disease
Summary: Amyloid-β (Aβ) and tau proteins accumulate within distinct neuronal systems in Alzheimer’s disease (AD). Although it is not clear why certain brain regions are more vulnerable to Aβ and tau pathologies than others, gene expression may play a role. We study the association between…
-
Artikel Jurnal
CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron emission tomography in 3046 participants from 12…