12 results for "Muhammad Saboor"
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Journal Article
Erythroferrone in focus: emerging perspectives in iron metabolism and hematopathologies
Beyond its core role in iron metabolism, erythroferrone (ERFE) has emerged as a key player with far-reaching implications in various hematologic disorders. Its regulatory effect on hepcidin underlines its significance in conditions characterized by disrupted iron homeostasis. In β-thalassemia and…
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Journal Article
The tumor microenvironment in hematologic malignancies: immune evasion, metabolic reprogramming, and therapeutic resistance
Hematological malignancies, including leukemia, lymphoma, and multiple myeloma, develop within and remain dependent on a complex and dynamic tumor microenvironment (TME). Malignant cells interact continuously with the cellular and molecular components of the TME, which play a critical role in…
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Journal Article
The JAK-STAT pathway in rheumatoid arthritis: from mechanisms to JAK inhibitors
Abstract Background Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder characterized by synovial inflammation, cartilage degradation and progressive joint destruction. The pathogenesis of RA involves a complex interaction among immune cells, pro-inflammatory cytokines and…
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Journal Article
Evaluation of FGL1 as a hepatokine marker in iron deficiency
BackgroundFibrinogen-like protein 1 (FGL1) is a hepatokine that regulates hepcidin through antagonism of the bone morphogenetic protein (BMP) pathway. Although preclinical studies suggest a role for FGL1 in iron metabolism, its clinical behavior in human iron deficiency anemia (IDA) remains…
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Journal Article Full text
Spatial patterns and environmental functions of dissolved organic matter in grassland soils of China
Soil dissolved organic matter (DOM) is crucial to atmospheric, terrestrial and aquatic environments as well as human life. Here, by characterizing DOM from 89 grassland soils throughout China, we reveal the spatial association between DOM geochemistry in the dry season vs annual ecosystem exchange…
Also available at: DOAJ
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Journal Article Full text
Manipulating the Spin State of Perovskite Cs(3)Bi(2)Br(9) by Co‐Doped for Efficient Photocatalytic CO(2) Reduction
The photocatalytic conversion of CO(2) into the renewable fuels is a promising strategy to address energy and environmental challenges, however, its limited application is mainly attributed to the inefficient charge separation and lack of active sites in conventional catalysts. Here, a…
Also available at: DOAJ
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Journal Article
Retinoblastoma: An update on genetic origin, classification, conventional to next-generation treatment strategies
The most prevalent paediatric vision-threatening medical condition, retinoblastoma (RB), has been a global concern for a long time. Several conventional therapies, such as systemic chemotherapy and focal therapy, have been used for curative purposes; however, the search for tumour eradication with…
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Journal Article
Natural products in the management of neurodegenerative diseases
Abstract Neurodegenerative diseases represent one of the utmost imperative well-being health issues and apprehensions due to their escalating incidence of mortality. Natural derivatives are more efficacious in various preclinical models of neurodegenerative illnesses. These natural compounds…
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Journal Article Full text
Assessment of Coagulopathy Risk in Type 2 Diabetes Mellitus: A Retrospective Cross-Sectional Study in Thumbay Hospital, UAE
Background: Type 2 diabetes mellitus(T2DM) is associated with coagulation abnormalities and a higher risk for blood clots due to changes in the clotting factors and platelet function. This study aimed to assess blood clotting parameters in T2DM patients within a single research center in the UAE…
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Journal Article
Possible neglected transient (T) polyagglutination in critically ill patients with coronavirus disease-2019 (Covid-19)
T-activation polyagglutination can be caused by bacteria or viruses and has been associated with haemolytic anaemia. Coronavirus disease-19 (COVID-19) is also associated with haemolytic anaemia. The presented study aims to determine T activation polyagglutination in critically ill COVID-19…