13 hasil untuk "Pascal Steiner"

Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex.

Christel Genoud; Charles Quairiaux; Pascal Steiner dkk.

PLoS Biology, Vol. 4 No. 11 · 2006 · Inggris · DOAJ Scopus

Astrocytes play a major role in the removal of glutamate from the extracellular compartment. This clearance limits the glutamate receptor activation and affects the synaptic response. This function of the astrocyte is dependent on its positioning around the synapse, as well as on the level of…

Juga tersedia di: PLOS

Fine tuning microfibrillated cellulose dispersity and sulphur reactivities with dual modifiers for improving elastomer nanocomposite reinforcement

Iikpoemugh Elo Imiete; Mariapaola Staropoli; Ming Liu dkk.

Carbohydrate Polymer Technologies and Applications, Vol. 11 · 2025 · Inggris · DOAJ Scopus

Micro fibrillated cellulose (MFC) is a promising filler that can reinforce elastomeric compounds, and make tire materials more sustainable, lightweight and highly reinforced. Due to the hydrophilic nature of MFC, modification is required to promote dispersion and adhesion in hydrophobic elastomers…

Early Life to Adult Brain Lipidome Dynamic: A Temporospatial Study Investigating Dietary Polar Lipid Supplementation Efficacy

Manuel Oliveira; Kyoko Koshibu; Andreas Rytz dkk.

Frontiers in Nutrition, Vol. 9 · 2022 · Inggris · DOAJ Scopus

The lipid composition of the brain is well regulated during development, and the specific temporospatial distribution of various lipid species is essential for the development of optimal neural functions. Dietary lipids are the main source of brain lipids and thus contribute to the brain lipidome…

Pilot-scale production of monodisperse helical silica nanorods: As-synthesized structure and application to rubber compounds

Vincent Rogé; Mariapaola Staropoli; Enzo Moretto dkk.

Materials & Design, Vol. 269 · 2026 · Inggris · DOAJ Scopus

This work discloses a pilot-scale synthesis process allowing the growth of monodispersed silica (SiO2) nanorods, using cost effective and nontoxic reactants only. Water is here the only solvent used, with cetyltrimethylammonium chloride (CTACl) micelles acting as soft templates to control the…

Glutathione in the nucleus accumbens regulates motivation to exert reward-incentivized effort

Ioannis Zalachoras; Eva Ramos-Fernández; Fiona Hollis dkk.

eLife, Vol. 11 · 2022 · Inggris · DOAJ

Emerging evidence is implicating mitochondrial function and metabolism in the nucleus accumbens in motivated performance. However, the brain is vulnerable to excessive oxidative insults resulting from neurometabolic processes, and whether antioxidant levels in the nucleus accumbens contribute to…

SAHA Enhances Synaptic Function and Plasticity In Vitro but Has Limited Brain Availability In Vivo and Does Not Impact Cognition

Jesse E. Hanson; Hank La; Emile Plise dkk.

PLoS ONE, Vol. 8 No. 7 · 2013 · Inggris · PLOS Scopus

Suberoylanilide hydroxamic acid (SAHA) is an inhibitor of histone deacetylases (HDACs) used for the treatment of cutaneous T cell lymphoma (CTCL) and under consideration for other indications. In vivo studies suggest reducing HDAC function can enhance synaptic function and memory, raising the…

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Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

Qinghong Li; Max Homilius; Erin Achilles dkk.

ESC Heart Failure, Vol. 12 No. 2 · 2025 · Inggris · DOAJ Scopus

Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress. Hypertrophic cardiomyopathy (HCM) is a…

Macroencapsulated Human iPSC-Derived Pancreatic Progenitors Protect against STZ-Induced Hyperglycemia in Mice

Corinne Haller; Julie Piccand; Filippo De Franceschi dkk.

Stem Cell Reports, Vol. 12 No. 4 · 2019 · Inggris · DOAJ Scopus

Summary: In type 1 diabetes, a renewable source of human pancreatic β cells, in particular from human induced pluripotent stem cell (hiPSC) origin, would greatly benefit cell therapy. Earlier work showed that pancreatic progenitors differentiated from human embryonic stem cells in vitro can further…

Human and Bovine Milk Oligosaccharides Elicit Improved Recognition Memory Concurrent With Alterations in Regional Brain Volumes and Hippocampal mRNA Expression

Stephen A. Fleming; Austin T. Mudd; Jonas Hauser dkk.

Frontiers in Neuroscience, Vol. 14 · 2020 · Inggris · DOAJ Scopus

Human milk contains a unique profile of oligosaccharides (OS) and preliminary evidence suggests they impact brain development. The objective of this study was to assess the impact of bovine and/or human milk oligosaccharides (HMO) (2′-fucosyllactose and Lacto-N-neotetraose) on cognition, brain…

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Karpagam Srinivasan; Brad A. Friedman; Jessica L. Larson dkk.

Nature Communications, Vol. 7 No. 1 · 2016 · Inggris · DOAJ Scopus

Whole tissue RNA profiling can help identify altered molecular pathways underlying neurodegenerative disease, but often masks cell type-specific transcriptional changes. Here, the authors compare transcriptomes of neurons, astrocytes, and microglia from Alzheimer's disease model brains and identify…

A Nutrient Formulation Affects Developmental Myelination in Term Infants: A Randomized Clinical Trial

Nora Schneider; Muriel M. K. Bruchhage; Barry V. O'Neill dkk.

Frontiers in Nutrition, Vol. 9 · 2022 · Inggris · DOAJ Scopus

Background and ObjectivesObservational studies suggest differences between breast-fed and formula-fed infants in developmental myelination, a key brain process for learning. The study aims to investigate the efficacy of a blend of docosahexaenoic acid (DHA), arachidonic acid (ARA), iron, vitamin…