9 hasil untuk "Pranavkumar Shivakumar"

“Complimenting the Complement”: Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma

Astha Malik; Unmesha Thanekar; Surya Amarachintha dkk.

Frontiers in Oncology, Vol. 10 · 2021 · Inggris · DOAJ Scopus

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and a leading cause of death in the US and worldwide. HCC remains a global health problem and is highly aggressive with unfavorable prognosis. Even with surgical interventions and newer medical treatment regimens…

Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia

Junbae Jee; Reena Mourya; Pranavkumar Shivakumar dkk.

PLOS ONE, Vol. 12 No. 8 · 2017 · Inggris · PLOS Scopus

Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signaling via its Cxcr2 receptor have been linked to…

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Natural Killer Cells Promote Long-Term Hepatobiliary Inflammation in a Low-Dose Rotavirus Model of Experimental Biliary Atresia

James E. Squires; Pranavkumar Shivakumar; Reena Mourya dkk.

PLOS ONE, Vol. 10 No. 5 · 2015 · Inggris · PLOS Scopus

Conclusions: Lower inoculation of RRV-induced progressive liver injury and fibrosis via NK cells. These findings point to the potential use of NK cell-depleting strategies to block progression of liver disease in biliary atresia.

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Editorial: Infants with cholestasis

Hiroo Uchida; Gregory M. Tiao; Pranavkumar Shivakumar dkk.

Frontiers in Pediatrics, Vol. 11 · 2023 · Inggris · DOAJ Scopus

Serum Proteomics Uncovers Biomarkers of Clinical Portal Hypertension in Children With Biliary Atresia

Julie Osborn; Reena Mourya; Unmesha Thanekar dkk.

Hepatology Communications, Vol. 6 No. 5 · 2022 · Inggris · DOAJ Scopus

Children with biliary atresia (BA) often develop portal hypertension (PHT) and its complications, which are associated with high morbidity and mortality. The goal of this study was to identify serum biomarkers of PHT by using large‐scale proteomics. We applied the slow off‐rate modified aptamer…

Cellular crosstalk mediated by TGF-β drives epithelial-mesenchymal transition in patient-derived multi-compartment biliary organoids

Hiroaki Ayabe; Erica A. K. DePasquale; Surya P. Amarachintha dkk.

Nature Communications, Vol. 16 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Deficiencies in the development of epithelial structures and delays in cellular maturation can increase the susceptibility of neonates to disease early in life. To investigate human biliary development and its vulnerability to biliary atresia, a severe pediatric cholangiopathy, we…

Maternal regulation of biliary disease in neonates via gut microbial metabolites

Jai Junbae Jee; Li Yang; Pranavkumar Shivakumar dkk.

Nature Communications, Vol. 13 No. 1 · 2022 · Inggris · DOAJ Scopus

The pathogenesis of biliary atresia remains poorly understood. Here, the authors report that maternal butyrate treatment alters the gut microbiome and glutamine/hypoxanthine metabolites similar to human subjects, and suppresses biliary atresia in newborn mice.