9 hasil untuk "Reji Manjunathan"
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In ovo administration of human recombinant leptin shows dose dependent angiogenic effect on chicken chorioallantoic membrane
BACKGROUND: Leptin, the cytokine produced by white adipose tissue is known to regulate food energy homeostasis through its hypothalamic receptor. In vitro studies have demonstrated that leptin plays a major role in angiogenesis through binding to the receptor Ob-R present on ECs by stimulating and…
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In-Silico characterisation of antiviral activities of marine fungal derivatives: Focusing on TMPRSS2 as a therapeutic target
Marine fungi represent an underexplored source of bioactive metabolites with significant antiviral potential. The enzyme TMPRSS2, which primes the SARS-CoV-2 spike protein, is a crucial target for preventing viral entry into cells. Natural TMPRSS2 inhibitors derived from marine fungi offer…
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High molecular weight heparin-induced angiogenesis mainly mediated via basic fibroblast growth factor-2- an in-vivo (CAM) and in-silico analysis
Background: High-molecular weight heparin (HMWH), a molecule extensively used as an anticoagulant, shows concentration-dependent angiogenic and anti-angiogenic potential. So far, no studies have reported the interactive potential of HMWH with various pro-angiogenic growth factors under…
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Post-transport TOPS score as a predictive marker of mortality among transported neonates and its comparative analysis with SNAP-II PE
Aim: Multiple parameters are available to predict the outcome of critically sick neonates admitted in neonatal intensive care unit (NICU). Main aim of the study is to validate the role of TOPS, especially the post-transport TOPS score as a simplified assessment of neonatal acute physiology in…
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Aetiological Profiles of Pancytopenia in Children between 2 months to 12 years of Age- A Retrospective Study from a Tertiary Care Centre, Chennai, India
Introduction: Pancytopenia is a medical condition that generally exists among children in which the peripheral blood cell lineages are found to reduce in blood. The condition is diagnosed as a common haematological problem with an extensive differential diagnosis and vary according to the…
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Correlation of non-clinical parameters with the hematological indices in type 2 diabetic Mellitus patients
Background: The study's main aim is to compare and correlate the levels of various hematological indices in type 2 DM patients with the gender, age, duration, and family history of diabetic conditions to predict diabetes-related complications. Methods: The diabetic population is divided into 2…
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Cytological Profile of Solid and Cystic Lesions Arising from Various Sites in the Body: A Cross-sectional Study
Introduction: Fine Needle Aspiration Cytology (FNAC) is a minimally invasive, cost-effective, and efficient technique for obtaining diagnostic cellular material with minimal discomfort and a low patient complication rate. Aim: To study various solid and cystic lesions in the body using FNAC…
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Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein
Abstract Background The Transmembrane Serine Protease 2 (TMPRSS2) of human cell plays a significant role in proteolytic cleavage of SARS-Cov-2 coronavirus spike protein and subsequent priming to the receptor ACE2. Approaching TMPRSS2 as a therapeutic target for the inhibition of SARS-Cov-2…
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Artikel Jurnal Teks lengkap
An Overview on the Therapeutic Function of Foods Enriched with Plant Sterols in Diabetes Management
Diabetes is one of the most significant health issues across the world. People identified with diabetes are more vulnerable to various infections and are at a greater risk of developing cardiovascular diseases. The plant-based food we consume often contains many sterol-based bioactive compounds. It…