12 results for "Renee D Stapleton"

How the Hospital Works: An Interdisciplinary, Systems-Based Practice Medical Student Elective

Andrew J Hale; Jason Bartsch; Renee D Stapleton et al.

Journal of Medical Education and Curricular Development, Vol. 10 · 2023 · English · DOAJ

OBJECTIVES Although proficient systems-based practice is a foundational skill for physicians, how best to teach it has not been well established. An elective course for fourth-year medical students wherein participants had an immersive experience with multiple interprofessional staff was created…

Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome

Anthony J. Esposito; Pavan K. Bhatraju; Renee D. Stapleton et al.

Critical Care, Vol. 21 No. 1 · 2017 · English · DOAJ Scopus

Abstract Background Hyaluronic acid (HA), an extracellular matrix component, is degraded in response to local tissue injury or stress. In various animal models of lung injury, HA has been shown to play a mechanistic role in modulating inflammation and injury. While HA is present in the lungs of…

History of Adverse Pregnancy Outcomes in Women With Pulmonary Arterial Hypertension: A Single‐Center Pilot Study

Jessica B. Badlam; Renee D. Stapleton; Peter W. Callas et al.

Pulmonary Circulation, Vol. 15 No. 2 · 2025 · English · DOAJ Scopus

ABSTRACT Single‐center pilot study suggests a threefold increase in self‐reported history of adverse pregnancy outcomes (APO) among women with subsequent diagnosis of pulmonary arterial hypertension (PAH). Females with PAH and a history of APO were younger and had higher mean pulmonary artery…

Skeletal Muscle Myofibers Directly Contribute to LPS-Induced Systemic Inflammatory Tone

Joseph J. Bivona III; Madeleine M. Mank; Renee D. Stapleton et al.

Frontiers in Pharmacology, Vol. 13 · 2022 · English · DOAJ Scopus

The abundance, anatomical distribution, and vascularity of skeletal muscle make it a potentially important contributor to local cytokine production and systemic cytokine abundance during inflammatory events. An orchestrated balance between the production of pro- and anti-inflammatory mediators is…

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

Jennifer H. Madenspacher; Eric D. Morrell; Jeffrey G. McDonald et al.

JCI Insight, Vol. 8 No. 7 · 2023 · English · DOAJ Scopus

Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined. Recently, we reported that Ch25h is induced in monocyte-derived macrophages recruited to the airspace during resolution…

Kinetics and isotype assessment of antibodies targeting the spike protein receptor‐binding domain of severe acute respiratory syndrome‐coronavirus‐2 in COVID‐19 patients as a function of age, biological sex and disease severity

Nancy R Graham; Annalis N Whitaker; Camilla A Strother et al.

Clinical & Translational Immunology, Vol. 9 No. 10 · 2020 · English · DOAJ Scopus

Abstract Objectives There is an incomplete understanding of the host humoral immune response to severe acute respiratory syndrome (SARS)‐coronavirus (CoV)‐2, which underlies COVID‐19, during acute infection. Host factors such as age and sex as well as the kinetics and functionality of antibody…

Metabolic support in the critically ill: a consensus of 19

Jan Wernerman; Kenneth B. Christopher; Djillali Annane et al.

Critical Care, Vol. 23 No. 1 · 2019 · English · DOAJ Scopus

Abstract Metabolic alterations in the critically ill have been studied for more than a century, but the heterogeneity of the critically ill patient population, the varying duration and severity of the acute phase of illness, and the many confounding factors have hindered progress in the field…

The role for high flow nasal cannula as a respiratory support strategy in adults: a clinical practice guideline

Bram N. Rochwerg; Sharon Einav; Dipayan Chaudhuri et al.

Intensive Care Medicine · 2020 · English · OpenAlex Scopus

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Shelsey W. Johnson, MD; Michael A. Garcia, MD; Emily K. Q. Sisson, MA et al.

Critical Care Explorations, Vol. 10 No. 2 · 2022 · English · DOAJ Scopus

OBJECTIVES:. To describe hospital variation in use of “guideline-based care” for acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN:. Retrospective, observational study. SETTING:. The Society of Critical Care Medicine’s Discovery Viral Infection and RESPIRATORY ILLNESS UNIVERSAL…

Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group

Michael A. Garcia, MD; Shelsey W. Johnson, MD; Nicholas A. Bosch, MD, MSc et al.

Critical Care Explorations, Vol. 3 No. 11 · 2021 · English · DOAJ Scopus

IMPORTANCE:. At the start of the coronavirus disease 2019 pandemic, medications repurposed for management of coronavirus disease 2019 were used in the absence of clinical trial evidence. OBJECTIVES:. To describe the variation and evolution in use of repurposed medications for coronavirus disease…

Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry

Sandeep Tripathi, MD, MS; Imran A. Sayed, MD; Heda Dapul, MD et al.

Critical Care Explorations, Vol. 3 No. 8 · 2021 · English · DOAJ Scopus

IMPORTANCE:. Even with its proclivity for older age, coronavirus disease 2019 has been shown to affect all age groups. However, there remains a lack of research focused primarily on the young adult population. OBJECTIVES:. To describe the epidemiology and outcomes of coronavirus disease 2019 and…

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic

Anna M. Cervantes-Arslanian, MD; Chakradhar Venkata, MD; Pria Anand, MD et al.

Critical Care Explorations, Vol. 4 No. 4 · 2022 · English · DOAJ Scopus

OBJECTIVES:. To describe the prevalence, associated risk factors, and outcomes of serious neurologic manifestations (encephalopathy, stroke, seizure, and meningitis/encephalitis) among patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DESIGN…