57 hasil untuk "Robert Jech"
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Artikel Jurnal
Progressive choreodystonia in X‐linked hyper‐IgM immunodeficiency: a rare but recurrent presentation
Abstract An association between movement disorders and immune‐system dysfunction has been described in the context of rare genetic diseases such as ataxia telangiectasia as well as infectious encephalopathies. We encountered a male patient who presented immunodeficiency of unknown etiology since…
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Artikel Jurnal
Directed functional connectivity of the default-mode-network of young and older healthy subjects
Abstract Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a…
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Artikel Jurnal Teks lengkap
Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.
The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T)…
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Artikel Jurnal
Directed functional connectivity of the sensorimotor system in young and older individuals
IntroductionStudies in the sensorimotor system of older versus young individuals have shown alterations in functional connectivity and organization. Our objective was to explore the implications of these differences in terms of local organizations, and to identify processes that correlate with…
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Artikel Jurnal
Evaluation of diagnostic concordance between algorithms for Parkinson’s disease dementia
Background: Significant number of patients with Parkinson’s disease (PD) gradually progress to Parkinson’s disease dementia (PDD). Recent proposal for updating current diagnostic criteria for PDD recommends alternative screening tests and broader functional assessments. Objective: To evaluate the…
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Artikel Jurnal
Technical considerations of functional MRI in deep brain stimulation: recent advances and future perspectives
Magnetic resonance imaging (MRI) is a valuable clinical and research tool for patients managed using deep brain stimulation (DBS). Unfortunately, MRI under these conditions is associated with substantial risks, necessitating stringent regulations that limit its clinical and research utility. In…
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Artikel Jurnal
Bridging structural and functional biomarkers in functional movement disorder using network mapping
Abstract Background There are gaps in our neurobiological understanding of functional movement disorder (FMD). Objectives We investigated gray matter volumetric profiles in FMD, and related findings to resting‐state functional connectivity (rsFC) profiles using Human Connectome Project data…
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Artikel Jurnal
General and selective brain connectivity alterations in essential tremor: A resting state fMRI study
Although essential tremor is the most common movement disorder, there is little knowledge about the pathophysiological mechanisms of this disease. Therefore, we explored brain connectivity based on slow spontaneous fluctuations of blood oxygenation level dependent (BOLD) signal in patients with…
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Artikel Jurnal Teks lengkap
Abnormal activity in the precuneus during time perception in Parkinson's disease: an fMRI study.
BackgroundParkinson's disease (PD) patients are deficient in time estimation. This deficit improves after dopamine (DA) treatment and it has been associated with decreased internal timekeeper speed, disruption of executive function and memory retrieval dysfunction.Methodology/findingsThe aim of the…
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Artikel Jurnal
Restoration of functional network state towards more physiological condition as the correlate of clinical effects of pallidal deep brain stimulation in dystonia
Background: Deep brain stimulation of the internal globus pallidus (GPi DBS) is an invasive therapeutic modality intended to retune abnormal central nervous system patterns and relieve the patient of dystonic or other motor symptoms. Objectives: The aim of the presented research was to determine…
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Artikel Jurnal Teks lengkap
Accounting for movement increases sensitivity in detecting brain activity in Parkinson's disease.
Parkinson's disease (PD) is manifested by motor impairment, which may impede the ability to accurately perform motor tasks during functional magnetic resonance imaging (fMRI). Both temporal and amplitude deviations of movement performance affect the blood oxygenation level-dependent (BOLD)…
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Artikel Jurnal Teks lengkap
3D visual cueing shortens the double support phase of the gait cycle in patients with advanced Parkinson's disease treated with DBS of the STN.
BackgroundGait disturbances have emerged as some of the main therapeutic concerns in late-stage Parkinson's disease (PD) treated with dopaminergic therapy and deep brain stimulation (DBS). External cues may help to overcome freezing of gait (FOG) and improve some of the gait parameters.AimTo…
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Artikel Jurnal
Resting-state functional magnetic resonance imaging of the subthalamic microlesion and stimulation effects in Parkinson's disease: Indications of a principal role of the brainstem
During implantation of deep-brain stimulation (DBS) electrodes in the target structure, neurosurgeons and neurologists commonly observe a “microlesion effect” (MLE), which occurs well before initiating subthalamic DBS. This phenomenon typically leads to a transitory improvement of motor symptoms of…
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Artikel Jurnal
Symptom-severity-related brain connectivity alterations in functional movement disorders
Background: Functional movement disorders, a common cause of neurological disabilities, can occur with heterogeneous motor manifestations including functional weakness. However, the underlying mechanisms related to brain function and connectivity are unknown. Objective: To identify brain…
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Artikel Jurnal
Sweet spot for resting-state functional MRI effect of deep brain stimulation in dystonia lies in the lower pallidal area
Introduction: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) is a well-established, effective treatment for dystonia. Substantial variability of therapeutic success has been the one of the drivers of an ongoing debate about proper stimulation site and settings, with several…