8 results for "Ruby Bansal"

A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B

Ruby Bansal; Shib Sankar Sen; Rohini Muthuswami et al.

PLOS Neglected Tropical Diseases, Vol. 13 No. 4 · 2019 · English · PLOS Scopus

Background: Leishmania donovani is a protozoan parasite, a primary causative agent of visceral leishmaniasis. Sterol produced via the mevalonate pathway, show differences in composition across biological kingdoms. The specific occurrence of Δ22-unsaturated sterols, containing a double bond at the…

Also available at: DOAJ

Targeting Leishmania donovani Sphingosine Kinase 1 using PF-543 enhances immune response and limits parasite load

Evanka Madan; Ruby Bansal; Jhalak Singhal et al.

PLOS Neglected Tropical Diseases, Vol. 20 No. 3 · 2026 · English · PLOS Scopus

Background: Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator regulating apoptosis, proliferation, and immune responses. While S1Ps presence in Leishmania donovani phagolysosomes has been reported, the role of sphingosine kinases, especially SphK1, in parasite survival and host immune…

Also available at: DOAJ

Selective targeting of Plasmodium falciparum hexose transporter by phytochemical Ginsenoside Rg1 disrupts glucose metabolism and blocks development of parasite

Sadat Shafi; Preeti Maurya; Ruby Bansal et al.

Antimicrobial Agents and Chemotherapy, Vol. 70 No. 7 · 2026 · English · DOAJ Scopus

ABSTRACT The emergence of resistance to first-line antimalarial therapies highlights the critical need for next-generation drugs that target distinct molecular pathways and employ novel mechanisms of action. Notably, the intra-erythrocytic parasite development is highly dependent on a sustained…

Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids

Rebecca Sebastian; Kang Jin; Narciso Pavon et al.

Nature Communications, Vol. 14 No. 1 · 2023 · English · DOAJ Scopus

Abstract De novo mutations and copy number deletions in NRXN1 (2p16.3) pose a significant risk for schizophrenia (SCZ). It is unclear how NRXN1 deletions impact cortical development in a cell type-specific manner and disease background modulates these phenotypes. Here, we leveraged human…

Chemical degradation of Human p38-MAPK reveals it as a potential host target to combat parasitic infections by Leishmania donovani and Plasmodium falciparum

Jhalak Singhal; Neha Rawat; Ruby Bansal et al.

Communications Biology, Vol. 9 No. 1 · 2026 · English · DOAJ Scopus

Abstract The interplay between host and parasite determines parasite burden and disease outcome. Parasite exploits host signaling pathways like p38-MAPK for its survival and pathogenesis. Here we have used NR-7h, a proteolysis-targeting chimera (PROTAC) targeting human p38-MAPK to assess p38-MAPK’s…

An Integrated Analysis to Understand the Dysregulation of Innate Immune Response in Mouse Models of MASLD

Yamini Goswami; Jyoti Gautam; Akash Baghel et al.

Cells, Vol. 15 No. 14 · 2026 · English · DOAJ Scopus

Background: Dysregulation of innate immune pathways is an important contributor to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Inflammasomes serve as key regulators of innate immunity. Emerging evidence suggests that nutrient status, particularly choline…