14 hasil untuk "Shreyaskumar Patel"
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Artikel Jurnal
An adaptive transformer-based framework for advanced brain activity mapping and intelligent neurotherapeutic decision support
IntroductionIdentification and treatment of neurological disorders depend much on brain imaging and neurotherapeutic decision support. Although they are loud, do not remain in one spot, and are rather complex, electroencephalogram (EEG) signals are the principal tool used in research of brain…
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Molecular Imaging with 3′-deoxy-3′[(18)F]-Fluorothymidine (18F-FLT) PET/CT for Early Response to Targeted Therapies in Sarcomas: A Pilot Study
Although 3′-deoxy-3′[(18)F]-fluorothymidine (FLT)-positron emission tomography (PET) has been utilized for tumor response assessment to neoadjuvant chemotherapy in soft tissue sarcomas, it has not been exploited for the assessment of early response to systematically targeted therapies. Herein, we…
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Artikel Jurnal
Characteristics and outcomes of patients with advanced sarcoma enrolled in early phase immunotherapy trials
Abstract Background Immunotherapies, specifically those based on immune checkpoint inhibitors, have shown promising activity in multiple tumor types. Other than mifamurtide (MEPACT®) for osteosarcoma approved by European Medicines Agency, there are no approved immunotherapies for sarcomas. Methods…
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Artikel Jurnal
Systematic Review of Surgical Treatment Outcomes of Prostate Metastases to the Spine
Introduction Treatment of symptomatic spinal metastases through surgical decompression and reconstruction is known to improve quality of life in patients with cancer. However, most studies have been performed on patients with mixed tumor histopathology. We systematically review the literature for…
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Latest Developments in Targeted Biological Therapies in the Management of Chordoma and Chondrosarcoma
STUDY DESIGN: Systematic review. OBJECTIVES: The objective of this review paper was to summarize targeted molecular therapy options for spinal chordoma and chondrosarcoma, and to provide an update on the relevant clinical trials open for recruitment. METHODS: A systematic review of the current…
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A Systematic Review of Clinical Outcomes and Prognostic Factors for Patients Undergoing Surgery for Spinal Metastases Secondary to Breast Cancer
Introduction Surgical treatment and cement augmentation procedures are effective palliative techniques for the treatment of symptomatic spinal metastases. However, clinical results specific to a breast cancer cohort are generally lacking. We aim to systematically review the literature for clinical…
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Artikel Jurnal
Retrospective evaluation of the role of gemcitabine‐docetaxel in well‐differentiated and dedifferentiated liposarcoma
Abstract Objective Well‐differentiated (WDLPS) and dedifferentiated liposarcoma (DDLPS) account for the majority of liposarcomas. Although gemcitabine‐docetaxel is used as second‐line treatment in soft tissue sarcomas, its efficacy in WDLPS/DDLPS is not established. This study retrospectively…
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Overview of Molecular Prognostication for Common Solid Tumor Histologies – What the Surgeon Should Know
STUDY DESIGN: Narrative Literature review. OBJECTIVE: To provide a general overview of important molecular markers and targeted therapies for the most common neoplasms (lung, breast, prostate and melanoma) that metastasize to the spine and offer guidance on how to best incorporate them in the…
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Artikel Jurnal
Immuno-genomic landscape of osteosarcoma
The efficacy of immune checkpoint inhibitors (ICI) in osteosarcoma has been limited. Here, the authors investigate the immunogenomic landscape of osteosarcoma, and integrated analyses highlight features related to a suppressed immune microenvironment.
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Artikel Jurnal
AO Spine Clinical Practice Recommendations: Current Systemic Oncological Treatments with the Largest Impact on Patients with Metastatic Spinal Disease
Study Design Literature review with clinical recommendation. Objective To provide the readers with a concise curation of the latest literature in recent advances in systemic oncological therapies and their implications for decision-making in patients with metastatic spinal disease. This review aims…
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Artikel Jurnal
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma
The activity of PD-1 blockade in patients with sarcoma has been modest so far. Here, the authors report the results of a pilot clinical trial to assess the efficacy and safety of bempegaldesleukin, a CD122-preferential interleukin-2 (IL-2) pathway agonist, in combination with the PD1 blockade…
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Artikel Jurnal
Dedifferentiated liposarcomas treated with immune checkpoint blockade: the MD Anderson experience
BackgroundDedifferentiated liposarcoma (DDLPS) is one of the most common types of soft tissue sarcoma (STS) characterized by liposarcomatous differentiation and a predilection for the retroperitoneum. Despite the growing number of histology-specific immune checkpoint blockade (ICB) trials in STS…
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The immune landscape of undifferentiated pleomorphic sarcoma
IntroductionUndifferentiated pleomorphic sarcoma (UPS) can be associated with a relatively dense immune infiltration. Immune checkpoint inhibitors (anti-PD1, anti-PDL1, and anti-CTLA4) are effective in 20% of UPS patients. We characterize the immune microenvironment of UPS and its association with…