15 hasil untuk "Simran Sharma"
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Artikel Jurnal Teks lengkap
Evidence of Antibiotic Resistance and Virulence Factors in Environmental Isolates of Vibrio Species
The outbreak of waterborne diseases such as cholera and non-cholera (vibriosis) is continuously increasing in the environment due to fecal and sewage discharge in water sources. Cholera and vibriosis are caused by different species of Vibrio genus which are responsible for acute diarrheal disease…
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Persistent vomiting in neurocritical care: Gastroesophageal junction nasogastric tube malposition as a diagnostic pitfall—A case report
Vomiting in neurocritical care patients is often attributed to raised intracranial pressure or neurological deterioration, which may delay consideration of reversible mechanical causes. We report a postoperative neurosurgical patient with chronic neurobrucellosis and raised intracranial pressure…
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Cost-effective computation of CCSD(T) energies via fragmentation
Abstract Conventional CCSD(T) calculations are widely considered as the gold standard for electronic structure theory. However, they become computationally prohibitive for medium- and large-sized molecular systems even with the high-end hardware. In this study, we evaluate the effectiveness of the…
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Structural modeling of phosphatidylinositol 3-kinase-γ with novel derivatives of stilbenoids
Phosphatidylinositol 3-kinases (PI3K) form a family of lipid kinases that catalyze the phosphorylation of 3-hydroxyl group of the inositol ring of phosphatidylinositol and its derivatives. It is implicated in inflammatory disorders and cancer thus making it an attractive drug target. Crystal…
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A comparative study of psychiatric comorbidity and quality of life between tension-type headache patients and healthy controls
Background: Headache is a health disorder that affects a large proportion of the world population, resulting in a huge economic burden. Nearly half the world’s population has a history of current headache disorder. Its prevalence is reported to vary over a wide range from 1.3% to 65% in men and…
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Artikel Jurnal Teks lengkap
Environmentally Relevant Concentrations of Triclosan Induce Cyto-Genotoxicity and Biochemical Alterations in the Hatchlings of Labeo rohita
Xenobiotic Triclosan (TCS) is of great concern because of its existence in a variety of personal, household and healthcare products and continuous discharge in water worldwide. Excessive use of TCS-containing sanitizers and antiseptic products during the COVID-19 pandemic further increased its…
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Determination of genetic diversity in indigenous cultivars of onion (Allium cepa L.) by multivariate analysis under mid hill zone of North- Western Himalayas, India
The present investigation was carried out at the Experimental Farm of the Department of Vegetable Science and Floriculture, CSK HPKV Palampur to assess the genetic divergence in indigenous cultivars of onion. Fifty eight genotypes were evaluated in Randomized Block Design with three replications…
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A comparison of burden of care in caregivers of patients with schizophrenia and obsessive-compulsive disorder
Background: Schizophrenia and obsessive-compulsive disorder (OCD) are two common and chronic psychiatric illnesses known to be associated with a considerable burden of caregiving. Various sociodemographic and clinical variables can influence the caregiving experience of the caregivers of these…
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Effect of frying on physicochemical and nutritional qualities of herbs and spices incorporated rice cracker
Herbs and spices are rich in bioactive compounds that are known to impart health benefits. Incorporation of these herbs/spices in snacks might also enhance the nutritional quality of the products. This study aimed to examine the potential nutritional benefits and loss associated with the frying of…
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Cellular, molecular and genomic alterations in the hatchlings of Labeo rohita after exposure to Triclosan
Triclosan 5-chloro-2-(2, 4-dichlorophenoxy) phenol (TCS) is widely used as a biocide in human and veterinary medicines, personal care products and household articles. To obtain biomarkers for the acute stress of Triclosan, the hatchlings of Labeo rohita were exposed for 96 h to 0.06, 0.067 and…
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Artikel Jurnal Teks lengkap
Validating Immunomodulatory Responses of r-LdODC Protein and Its Derived HLA-DRB1 Restricted Epitopes against Visceral Leishmaniasis in BALB/c Mice
Vaccination is considered the most appropriate way to control visceral leishmaniasis (VL). With this background, the r-LdODC protein as well as its derived HLA-DRB1-restricted synthetic peptides (P1: RLMPSAHAI, P2: LLDQYQIHL, P3: GLYHSFNCI, P4: AVLEVLSAL, and P5: RLPASPAAL) were validated in BALB/c…
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Immunogenicity and protective efficacy of nanoparticle formulations of L-SseB against Salmonella infection
Salmonella enterica, a Gram-negative pathogen, has over 2500 serovars that infect a wide range of hosts. In humans, S. enterica causes typhoid or gastroenteritis and is a major public health concern. In this study, SseB (the tip protein of the Salmonella pathogenicity island 2 type III secretion…
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mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol
Introduction Maternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs of sepsis and can result in delays in recognition and treatment. Identifying biomarkers that can reliably diagnose sepsis will reduce morbidity and mortality and…
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nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis—protocol for a prospective multicohort study
Introduction Diagnosing neonatal sepsis is heavily dependent on clinical phenotyping as culture-positive body fluid has poor sensitivity, and existing blood biomarkers have poor specificity.A combination of machine learning, statistical and deep pathway biology analyses led to the identification of…
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Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study
Introduction Early recognition and appropriate management of paediatric sepsis are known to improve outcomes. A previous system’s biology investigation of the systemic immune response in neonates to sepsis identified immune and metabolic markers that showed high accuracy for detecting bacterial…