60 hasil untuk "Stuart M Levitz"
Menampilkan 1–20 · 0,50 detik · RSS
-
Artikel Jurnal
Compounding drugs contaminated with fungi: a recipe for disaster
Emerging Microbes & Infections (2012) 1, e41; doi:10.1038/emi.2012.46 An ongoing outbreak of fungal meningitis in the United States has been traced to injections of contaminated corticosteroids produced by a compounding pharmacy.
-
Artikel Jurnal
When Community-Acquired Pneumonia Guidelines Provide Misguided Guidance
Limited diagnostic testing and empirical antimicrobial therapy are recommended in practice guidelines for adults with community-acquired pneumonia (CAP). Although following CAP guidelines is cost-effective with high cure rates, consideration should be given to the possibility that CAP is caused by…
-
Artikel Jurnal Teks lengkap
Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells.
BackgroundAn experimental approach for improving vaccine efficacy involves targeting antigens to mannose receptors (MRs) on dendritic cells (DCs) and other professional antigen presenting cells. Previously, we demonstrated that mannosylated Pichia pastoris-derived recombinant proteins exhibited…
Juga tersedia di: PLOS
-
Artikel Jurnal
Dynamic Virulence: Real-Time Assessment of Intracellular Pathogenesis Links Cryptococcus neoformans Phenotype with Clinical Outcome
ABSTRACT While a myriad of studies have examined host factors that predispose persons to infection with the opportunistic fungal pathogen Cryptococcus neoformans, comparatively little has been done to examine how virulence factor differences among cryptococcal isolates may impact outcome. In the…
-
Artikel Jurnal Teks lengkap
How post-translational modifications in pathogenic fungi inform pathogenesis and immune responses.
Juga tersedia di: PLOS
-
Artikel Jurnal Teks lengkap
Direct inhibition of T-cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan.
The major virulence factor of the pathogenic fungi Cryptococcus neoformans and C. gattii is the capsule. Glucuronoxylomannan (GXM), the major component of the capsule, is a high-molecular-weight polysaccharide that is shed during cryptococcosis and can persist in patients after successful…
Juga tersedia di: PLOS
-
Artikel Jurnal
Vaccines for human fungal diseases: close but still a long way to go
Abstract Despite the substantial global burden of human fungal infections, there are no approved fungal vaccines to protect at risk individuals. Here, we review the progress that has been made and the challenges that lie ahead in the quest towards efficacious fungal vaccines. In mouse studies…
-
Artikel Jurnal
Cooperative stimulation of dendritic cells by Cryptococcus neoformans mannoproteins and CpG oligodeoxynucleotides.
While mannosylation targets antigens to mannose receptors on dendritic cells (DC), the resultant immune response is suboptimal. We hypothesized that the addition of toll-like receptor (TLR) ligands would enhance the DC response to mannosylated antigens. Cryptococcus neoformans mannoproteins (MP)…
-
Artikel Jurnal
Reemergence of Intravenous Drug Use as Risk Factor for Candidemia, Massachusetts, USA
The epidemic of illicit intravenous drug use (IVDU) in the United States has been accompanied by a surge in drug overdose deaths and infectious sequelae. Candida albicans infections were associated with injection of contaminated impure brown heroin in the 1970s–1990s; however, candidiasis…
-
Artikel Jurnal
Robust Stimulation of Humoral and Cellular Immune Responses following Vaccination with Antigen-Loaded β-Glucan Particles
ABSTRACT β-Glucan particles (GPs) are purified Saccharomyces cerevisiae cell walls treated so that they are primarily β1,3-d-glucans and free of mannans and proteins. GPs are phagocytosed by dendritic cells (DCs) via the Dectin-1 receptor, and this interaction stimulates proinflammatory cytokine…
-
Artikel Jurnal
All You Need to Know and More about the Diagnosis and Management of Rare Mold Infections
Invasive mold infections caused by molds other than Aspergillus
-
Artikel Jurnal Teks lengkap
Contributions of the MyD88-dependent receptors IL-18R, IL-1R, and TLR9 to host defenses following pulmonary challenge with Cryptococcus neoformans.
Signaling via the adapter protein, MyD88, is important in the host defense against Cryptococcus neoformans infection. While certain Toll-like receptors (TLRs) can enhance the clearance of Cryptococcus, the contributions of MyD88-dependent, TLR-independent pathways have not been fully investigated…
-
Artikel Jurnal
Immune evasion by Cryptococcus gattii in vaccinated mice coinfected with C. neoformans
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over 100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to clinical trials. In preclinical studies, mice vaccinated with an attenuated strain of C. neoformans deleted of three…