15 hasil untuk "Zhe-Rui Zhang"

A single-dose chimeric Newcastle disease virus (NDV)/chikungunya virus (CHIKV) is an effective CHIKV vaccine candidate

Qiu-Yan Zhang; Yang Zhang; Zhe-Rui Zhang dkk.

Journal of Virology, Vol. 100 No. 8 · 2026 · Inggris · DOAJ Scopus

ABSTRACT With the broad spread of the chikungunya virus (CHIKV), there is an increasing demand for more effective and protective vaccines. In this study, we first developed a Newcastle disease virus (NDV) vector vaccine candidate expressing the complete envelope (E3–E1) protein of CHIKV. The…

Research progress and prospect of Fe−Mn−Al−C medium Mn steels

Ren-bo SONG; Wei-feng HUO; Nai-peng ZHOU dkk.

工程科学学报, Vol. 42 No. 7 · 2020 · Tionghoa · DOAJ Scopus

As vehicle ownership increases, the trend lightweight design puts energy consumption and environmental concerns on automotive steel. The research concept of the third generation of automotive steel currently under development is to combine the addition of lightweight elements with “light” and…

In Vivo Angiogenesis Screening and Mechanism of Action of Novel Tanshinone Derivatives Produced by One-Pot Combinatorial Modification of Natural Tanshinone Mixture from Salvia Miltiorrhiza

Zhe-Rui Zhang; Jin-Hang Li; Shang Li dkk.

PLoS ONE, Vol. 9 No. 7 · 2014 · Inggris · PLOS Scopus

Background: Natural products present in low quantity in herb medicines constitute an important source of chemical diversity. However, the isolation of sufficient amounts of these low abundant constituents for structural modification has been a challenge for several decades and subsequently halts…

Juga tersedia di: DOAJ

Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion

Zhe-Rui Zhang; Ya-Nan Zhang; Hong-Qing Zhang dkk.

PLOS Neglected Tropical Diseases, Vol. 16 No. 4 · 2022 · Inggris · PLOS Scopus

COVID-19 caused by SARS-CoV-2 has posed a significant threat to global public health since its outbreak in late 2019. Although there are a few drugs approved for clinical treatment to combat SARS-CoV-2 infection currently, the severity of the ongoing global pandemic still urges the efforts to…

Juga tersedia di: DOAJ

A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 replicon

Na Li; Xiao-Ling Chen; Qi Li dkk.

Emerging Microbes and Infections, Vol. 11 No. 1 · 2022 · Inggris · DOAJ Scopus

The extremely high transmission rate of SARS-CoV-2 and severe cases of COVID-19 pose the two critical challenges in the battle against COVID-19. Increasing evidence has shown that the viral spike (S) protein-driven syncytia may be responsible for these two events. Intensive attention has thus been…

Mutation in enterovirus 71 nonstructural protein 3A increases genome replication fidelity and exhibits attenuated virulence in mice

Fang Yu; Dongyan Xiong; Yao Zhong dkk.

Journal of Virology, Vol. 99 No. 10 · 2025 · Inggris · DOAJ Scopus

ABSTRACT Increasing numbers of studies have highlighted the important implications of the replication fidelity of RNA viruses for virus replication, pathogenesis, and the development of antiviral drugs and live-attenuated vaccines. However, most of the research has focused on viral polymerase, and…

Different pathogenesis of SARS-CoV-2 Omicron variant in wild-type laboratory mice and hamsters

Ya-Nan Zhang; Zhe-Rui Zhang; Hong-Qing Zhang dkk.

Signal Transduction and Targeted Therapy, Vol. 7 No. 1 · 2022 · Inggris · DOAJ Scopus

Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice

Jia-Qi Li; Zhe-Rui Zhang; Hong-Qing Zhang dkk.

Signal Transduction and Targeted Therapy, Vol. 6 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing antibodies are a leading class of biological products against various infectious viral pathogen. In this study, we develop a safe and cost-effective platform to express neutralizing antibody in the lung with…

An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant

Hong-Qing Zhang; Ya-Nan Zhang; Zhe-Rui Zhang dkk.

Signal Transduction and Targeted Therapy, Vol. 7 No. 1 · 2022 · Inggris · DOAJ Scopus

Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2

Ya-Nan Zhang; Zhe-Rui Zhang; Hong-Qing Zhang dkk.

Cell Discovery, Vol. 7 No. 1 · 2021 · Inggris · DOAJ Scopus

Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture

Ya-Nan Zhang; Qiu-Yan Zhang; Xiao-Dan Li dkk.

Emerging Microbes and Infections, Vol. 9 No. 1 · 2020 · Inggris · DOAJ Scopus

The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and…

ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker

Yuning Chen; Ya-Nan Zhang; Renhong Yan dkk.

Signal Transduction and Targeted Therapy, Vol. 6 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract The evolution of coronaviruses, such as SARS-CoV-2, makes broad-spectrum coronavirus preventional or therapeutical strategies highly sought after. Here we report a human angiotensin-converting enzyme 2 (ACE2)-targeting monoclonal antibody, 3E8, blocked the S1-subunits and pseudo-typed…

PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Zhihao Zhang; Jinhu Zhou; Peng Ni dkk.

npj Vaccines, Vol. 8 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had and continues to have a significant impact on global public health. One of the characteristics of SARS-CoV-2 is a surface homotrimeric spike protein, which is primarily responsible for the host immune response upon infection…