40,148 results
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Advanced oxidation processes for water and wastewater treatment – Guidance for systematic future research
Advanced oxidation processes (AOPs) are a growing research field with a large variety of different process variants and materials being tested at laboratory scale. However, despite extensive research in recent years and decades, many variants have not been transitioned to pilot- and full-scale…
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EzBioCloud: a genome-driven database and platform for microbiome identification and discovery
With the continued evolution of DNA sequencing technologies, the role of genome sequence data has become more integral in the classification and identification of Bacteria and Archaea. Six years after introducing EzBioCloud, an integrated platform representing the taxonomic hierarchy of Bacteria…
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Notch signaling pathway in cancer: from mechanistic insights to targeted therapies
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically…
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Global cancer burden growing, amidst mounting need for services
Global cancer burden growing, amidst mounting need for services
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A Recent Comprehensive Review of Fuel Cells: History, Types, and Applications
This review discusses the history, fundamentals, and applications of different fuel cell technologies, including proton exchange membrane fuel cells (PEMFCs), direct methanol fuel cells, solid oxide fuel cells (SOFCs), phosphoric acid fuel cells (PAFCs), alkaline fuel cells (AFCs), and molten…
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Rational molecular and device design enables organic solar cells approaching 20% efficiency
For organic solar cells to be competitive, the light-absorbing molecules should simultaneously satisfy multiple key requirements, including weak-absorption charge transfer state, high dielectric constant, suitable surface energy, proper crystallinity, etc. However, the systematic design rule in…
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Alternative splicing and related RNA binding proteins in human health and disease
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality. Across varying tissues, developmental stages, or under specific conditions, AS gives rise to distinct splice isoforms…
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A focused update to the 2019 NLA scientific statement on use of lipoprotein(a) in clinical practice
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Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
Pyroptosis is a type of programmed cell death characterized by cell swelling and osmotic lysis, resulting in cytomembrane rupture and release of immunostimulatory components, which play a role in several pathological processes. Significant cellular responses to various stimuli involve the formation…
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Updated resources for exploring experimentally-determined PDB structures and Computed Structure Models at the RCSB Protein Data Bank
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB, RCSB.org), the US Worldwide Protein Data Bank (wwPDB, wwPDB.org) data center for the global PDB archive, provides access to the PDB data via its RCSB.org research-focused web portal. We report substantial…
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A Review of Rechargeable Zinc–Air Batteries: Recent Progress and Future Perspectives
Zinc-air batteries (ZABs) are gaining attention as an ideal option for various applications requiring high-capacity batteries, such as portable electronics, electric vehicles, and renewable energy storage. ZABs offer advantages such as low environmental impact, enhanced safety compared to Li-ion…
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Barriers to and Facilitators of Artificial Intelligence Adoption in Health Care: Scoping Review
BACKGROUND: Artificial intelligence (AI) use cases in health care are on the rise, with the potential to improve operational efficiency and care outcomes. However, the translation of AI into practical, everyday use has been limited, as its effectiveness relies on successful implementation and…
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Colchicine in Acute Myocardial Infarction
BACKGROUND: Inflammation is associated with adverse cardiovascular events. Data from recent trials suggest that colchicine reduces the risk of cardiovascular events. METHODS: In this multicenter trial with a 2-by-2 factorial design, we randomly assigned patients who had myocardial infarction to…
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Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment
Diabetic peripheral neuropathy (DPN) refers to the development of peripheral nerve dysfunction in patients with diabetes when other causes are excluded. Diabetic distal symmetric polyneuropathy (DSPN) is the most representative form of DPN. As one of the most common complications of diabetes, its…
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Dubosiella newyorkensis modulates immune tolerance in colitis via the L-lysine-activated AhR-IDO1-Kyn pathway
Commensal bacteria generate immensely diverse active metabolites to maintain gut homeostasis, however their fundamental role in establishing an immunotolerogenic microenvironment in the intestinal tract remains obscure. Here, we demonstrate that an understudied murine commensal bacterium…
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Soil phosphorus transformation and plant uptake driven by phosphate-solubilizing microorganisms
Phosphorus (P) is an important nutrient for plants, and a lack of available P greatly limits plant growth and development. Phosphate-solubilizing microorganisms (PSMs) significantly enhance the ability of plants to absorb and utilize P, which is important for improving plant nutrient turnover and…
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Review of battery state estimation methods for electric vehicles - Part I: SOC estimation
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Heavy Metal Exposure and Cardiovascular Disease
Heavy metals are harmful environmental pollutants that have attracted widespread attention due to their health hazards to human cardiovascular disease. Heavy metals, including lead, cadmium, mercury, arsenic, and chromium, are found in various sources such as air, water, soil, food, and industrial…
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Targeted protein degradation: advances in drug discovery and clinical practice
Targeted protein degradation (TPD) represents a revolutionary therapeutic strategy in disease management, providing a stark contrast to traditional therapeutic approaches like small molecule inhibitors that primarily focus on inhibiting protein function. This advanced technology capitalizes on the…
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Therapeutic advances in rheumatoid arthritis
Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that typically affects symmetrically distributed small and large joints. Without effective treatment, significant joint damage…
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