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Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer
Oxygen is crucial for life and acts as the final electron acceptor in mitochondrial energy production. Cells adapt to varying oxygen levels through intricate response systems. Hypoxia-inducible factors (HIFs), including HIF-1α and HIF-2α, orchestrate the cellular hypoxic response, activating genes…
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European Association of Urology Guidelines on Urological Infections: Summary of the 2024 Guidelines
BACKGROUND AND OBJECTIVE: Urological infections significantly impact individuals' well-being and quality of life due to their widespread occurrence and diverse clinical manifestations. This work aims to provide evidence-based guidance on diagnosing, treating, and preventing urinary tract infections…
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Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that occurs following cardiovascular injury, thereby inducing subsequent damage while also…
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ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
MOTIVATION: The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded the chemical diversity of small molecules for drug discovery. Selecting compounds for experimental validation requires filtering…
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Wnt/β-catenin signaling components and mechanisms in bone formation, homeostasis, and disease
Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface to activate canonical or non-canonical Wnt signaling pathways, which control various biological processes throughout embryonic development and adult life. Aberrant Wnt signaling pathway underlies a wide…
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Macrophage plasticity: signaling pathways, tissue repair, and regeneration
Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a…
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A critical review of the reporting of reflexive thematic analysis in Health Promotion International
Using the concept of methodological congruence-where the different elements of a study 'fit' together-we explore both problematic and good practice in (reflexive) thematic analysis (TA) as reported in Health Promotion International (HPI). Aligning with the importance we place on 'owning your…
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Body Perceptions and Psychological Well-Being: A Review of the Impact of Social Media and Physical Measurements on Self-Esteem and Mental Health with a Focus on Body Image Satisfaction and Its Relationship with Cultural and Gender Factors
This narrative review examines the interplay among body image perceptions, social media influence, physical measurements, and their impact on psychological well-being, focusing on the roles of cultural and gender differences and the need to understand the research methodologies employed in this…
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Managing extreme AI risks amid rapid progress
Preparation requires technical research and development, as well as adaptive, proactive governance.
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Design and Development of Multi-Featured Medical Stretcher
The multi-featured medical stretcher represents a significant leap forward in patient care and hospital operations. Its innovative design combines various features aimed at enhancing both patient comfort and healthcare worker efficiency. At the core of its design is a commitment to making patient…
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Student perspectives on the use of generative artificial intelligence technologies in higher education
Abstract The aim of this project was to understand student perspectives on generative artificial intelligence (GAI) technologies such as Chat generative Pre-Trained Transformer (ChatGPT), in order to inform changes to the University of Liverpool Academic Integrity code of practice. The survey for…
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Ethical and regulatory challenges of large language models in medicine
With the rapid growth of interest in and use of large language models (LLMs) across various industries, we are facing some crucial and profound ethical concerns, especially in the medical field. The unique technical architecture and purported emergent abilities of LLMs differentiate them…
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Plant-Based Extracts as Reducing, Capping, and Stabilizing Agents for the Green Synthesis of Inorganic Nanoparticles
The synthesis of inorganic nanoparticles for diverse applications is an active research area that involves physical and chemical methods, which typically are expensive, involve hazardous chemical reagents, use complex equipment and synthesis conditions, and consume large amounts of time and energy…
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Ferroptosis in health and disease
Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membrane phospholipids, which eventually leads to…
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7. Diabetes Technology: Standards of Care in Diabetes—2025
The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA…
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10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025
The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA…
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Artikel Jurnal Teks lengkap
Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have emerged as promising therapeutic agents with potent anti-inflammatory properties and diverse clinical implications. This in-depth review article explores the mechanisms behind the anti-inflammatory actions of GLP-1RAs and assesses their…
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Mechanisms of long COVID and the path toward therapeutics
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) defined by medically unexplained symptoms following infection with SARS-CoV-2, is a newly recognized infection-associated chronic condition that causes disability in some people…
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A highly sensitive LITES sensor based on a multi-pass cell with dense spot pattern and a novel quartz tuning fork with low frequency
A highly sensitive light-induced thermoelectric spectroscopy (LITES) sensor based on a multi-pass cell (MPC) with dense spot pattern and a novel quartz tuning fork (QTF) with low resonance frequency is reported in this manuscript. An erbium-doped fiber amplifier (EDFA) was employed to amplify the…
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