52,982 results
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Smart Gas Sensors: Recent Developments and Future Prospective
Gas sensor is an indispensable part of modern society with wide applications in environmental monitoring, healthcare, food industry, public safety, etc. With the development of sensor technology, wireless communication, smart monitoring terminal, cloud storage/computing technology, and artificial…
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Hydrogen as a clean energy carrier: advancements, challenges, and its role in a sustainable energy future
Abstract This comprehensive review examines hydrogen’s potential as a pivotal clean energy carrier, focusing on its role in replacing fossil fuels across various industries. This study also examines recent advancements in hydrogen production technologies, including electrolysis, steam methane…
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Adoption and impacts of generative artificial intelligence: Theoretical underpinnings and research agenda
Large language models (LLMs) have received considerable interest in the field of natural language processing (NLP) owing to their remarkable ability to generate clear, consistent, and contextually relevant materials. Among the numerous LLMs, ChatGPT (Generative Pre-trained Transformer for Chatbots)…
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Nutrient-induced acidification modulates soil biodiversity-function relationships
Nutrient enrichment is a major global change component that often disrupts the relationship between aboveground biodiversity and ecosystem functions by promoting species dominance, altering trophic interactions, and reducing ecosystem stability. Emerging evidence indicates that nutrient enrichment…
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Ferroptosis: principles and significance in health and disease
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferroptosis has emerged as a crucial mechanism in…
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Quantitative phase imaging based on holography: trends and new perspectives
In 1948, Dennis Gabor proposed the concept of holography, providing a pioneering solution to a quantitative description of the optical wavefront. After 75 years of development, holographic imaging has become a powerful tool for optical wavefront measurement and quantitative phase imaging. The…
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Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
KRAS inhibitors demonstrate clinical efficacy in pancreatic ductal adenocarcinoma (PDAC); however, resistance is common. Among patients with KRASG12C-mutant PDAC treated with adagrasib or sotorasib, mutations in PIK3CA and KRAS, and amplifications of KRASG12C, MYC, MET, EGFR, and CDK6 emerged at…
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Regulation of exosomes as biologic medicines: Regulatory challenges faced in exosome development and manufacturing processes
With advances in medical technology, extracellular vesicles, also known as exosomes, are gaining widespread attention because of their potential therapeutic applications. However, their regulatory landscape is complex and varies across countries because of their unique intracellular mechanisms of…
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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice
Streptococcus anginosus (S. anginosus) was enriched in the gastric mucosa of patients with gastric cancer (GC). Here, we show that S. anginosus colonized the mouse stomach and induced acute gastritis. S. anginosus infection spontaneously induced progressive chronic gastritis, parietal cell atrophy…
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RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions
RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, and fibrinogen. RGD peptides' principal function is to facilitate cell adhesion by interacting with integrin receptors on the cell surface. They have been intensively researched for use in…
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Management of Fatigue in Adult Survivors of Cancer: ASCO–Society for Integrative Oncology Guideline Update
ASCO–Society for Integrative Oncology (SIO) Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following the guideline development process as outlined in the ASCO Guidelines Methodology Manual . ASCO-SIO Guidelines follow…
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Global nitrous oxide budget (1980–2020)
Nitrous oxide (N 2 O) is a long-lived potent greenhouse gas and stratospheric ozone-depleting substance that has been accumulating in the atmosphere since the preindustrial period. The mole fraction of atmospheric N 2 O has increased by nearly 25 % from 270 ppb (parts per billion) in 1750 to 336…
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Blinatumomab for MRD-Negative Acute Lymphoblastic Leukemia in Adults
BACKGROUND: Many older adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have a relapse despite having a measurable residual disease (MRD)-negative complete remission with combination chemotherapy. The addition of blinatumomab, a bispecific T-cell engager molecule that is approved…
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The interplay of learning, analytics and artificial intelligence in education: A vision for hybrid intelligence
Abstract This paper presents a multidimensional view of AI's role in education, emphasising the intricate interplay among AI, analytics and human learning processes. Here, I challenge the prevalent narrow conceptualisation of AI as tools in Education, exemplified in generative AI tools, and argue…
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Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer
BACKGROUND: Whether stereotactic body radiotherapy (SBRT) is noninferior to conventionally or moderately hypofractionated regimens with respect to biochemical or clinical failure in patients with localized prostate cancer is unclear. METHODS: We conducted a phase 3, international, open-label…
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TreeViewer : Flexible, modular software to visualise and manipulate phylogenetic trees
Phylogenetic trees illustrate evolutionary relationships between taxa or genes. Tree figures are crucial when presenting results and data, and by creating clear and effective plots, researchers can describe many kinds of evolutionary patterns. However, producing tree plots can be a time-consuming…
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A Survey of Beam Management for mmWave and THz Communications Towards 6G
Communication in millimeter wave (mmWave) and even terahertz (THz) frequency bands is ushering in a new era of wireless communications. Beam management, namely initial access and beam tracking, has been recognized as an essential technique to ensure robust mmWave/THz communications, especially for…
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