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Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding
Abstract Background The host–microbiota interaction plays a crucial role in maintaining homeostasis and disease susceptibility, and microbial tryptophan metabolites are potent modulators of host physiology. However, whether and how these metabolites mediate host–microbiota interactions…
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Developments in conducting polymer-, metal oxide-, and carbon nanotube-based composite electrode materials for supercapacitors: a review
In comparison to rechargeable batteries, supercapacitors have advantages such as quick charging and high power density. This review is focused on the progress in the development of electrode materials for supercapacitors using composite materials based on conducting polymers, graphene, metal oxide…
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Can Generative AI improve social science?
Generative AI that can produce realistic text, images, and other human-like outputs is currently transforming many different industries. Yet it is not yet known how such tools might influence social science research. I argue Generative AI has the potential to improve survey research, online…
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Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial
Retatrutide is a novel triple agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 and glucagon receptors. A 48-week phase 2 obesity study demonstrated weight reductions of 22.8% and 24.2% with retatrutide 8 and 12 mg, respectively. The primary objective of this…
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Tamizaje de cáncer de cuello uterino en mujeres de una región Andina del Perú
Objetivo: Determinar la caracterización del tamizaje de cáncer de cuello uterino vigente. Material y Método: Estudio descriptivo, retrospectivo, de fuente de información secundaria del 2022, incluyó a 90 384 mujeres. Para el cálculo de la cobertura se tomó en cuenta en el denominador a mujeres de…
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Personalized adaptive learning in higher education: A scoping review of key characteristics and impact on academic performance and engagement
Introduction: Higher education institutions face persistent challenges of student retention and academic progress. Personalized adaptive learning has the potential to address these issues as it leverages educational technology to tailor learning pathways according to individual student needs…
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Atlas of the plasma proteome in health and disease in 53,026 adults
Large-scale proteomics studies can refine our understanding of health and disease and enable precision medicine. Here, we provide a detailed atlas of 2,920 plasma proteins linking to diseases (406 prevalent and 660 incident) and 986 health-related traits in 53,026 individuals (median follow-up…
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Footprint characteristics revised for field-scale soil moisture monitoring with cosmic-ray neutrons
Cosmic-ray neutron probes are widely used to monitor environmental water content near the surface. The method averages over tens of hectares and is unrivaled in serving representative data for agriculture and hydrological models at the hectometer scale. Recent experiments, however, indicate that…
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Perioperative Care in Cardiac Surgery: A Joint Consensus Statement by the Enhanced Recovery After Surgery (ERAS) Cardiac Society, ERAS International Society, and The Society of Thoracic Surgeons (STS)
Enhanced Recovery After Surgery (ERAS) programs have been shown to lessen surgical insult, promote recovery, and improve postoperative clinical outcomes across a number of specialty operations. A core tenet of ERAS involves the provision of protocolized evidence-based perioperative interventions…
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VIENNA CONVENTION ON THE LAW OF TREATIES
The Vienna Convention on the Law of Treaties, adopted in 1969 and entering into force in 1980, stands as a cornerstone in international law, providing a comprehensive framework for the formation, interpretation, and termination of treaties between sovereign states.This abstract offers a succinct…
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Extreme Li-Mg selectivity via precise ion size differentiation of polyamide membrane
Abstract Achieving high selectivity of Li + and Mg 2+ is of paramount importance for effective lithium extraction from brines, and nanofiltration (NF) membrane plays a critical role in this process. The key to achieving high selectivity lies in the on-demand design of NF membrane pores in…
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Materials Advances in Photocatalytic Solar Hydrogen Production: Integrating Systems and Economics for a Sustainable Future
Photocatalytic solar hydrogen generation, encompassing both overall water splitting and organic reforming, presents a promising avenue for green hydrogen production. This technology holds the potential for reduced capital costs in comparison to competing methods like photovoltaic-electrocatalysis…
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Single-cell multiregion dissection of Alzheimer’s disease
. Here we report a single-cell transcriptomic atlas of six different brain regions in the aged human brain, covering 1.3 million cells from 283 post-mortem human brain samples across 48 individuals with and without Alzheimer's disease. We identify 76 cell types, including region-specific subtypes…
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Scaffold-based 3D cell culture models in cancer research
Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown in an environment that more closely mimics the 3D architecture and…
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What is the pipeline for future medications for obesity?
Obesity is a chronic disease associated with increased risk of obesity-related complications and mortality. Our better understanding of the weight regulation mechanisms and the role of gut-brain axis on appetite has led to the development of safe and effective entero-pancreatic hormone-based…
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