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Artikel Jurnal
Surgery followed by adjuvant radiotherapy versus definitive radiotherapy for locally advanced squamous cell carcinoma of the pharynx and larynx: a propensity score-matched analysis
Aim : Locally advanced squamous cell carcinoma (SCC) of the pharynx and larynx is commonly treated with either primary surgery followed by adjuvant radiotherapy (RT) or definitive RT with or without concurrent systemic therapy. Comparative outcome data between these treatment strategies remain…
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Artikel Jurnal
CyberKnife SBRT plus lenvatinib and tislelizumab versus doublet systemic therapy for hepatocellular carcinoma with macrovascular invasion: A real-world IPTW-adjusted study
Background & purpose: Macrovascular invasion (MVI) in hepatocellular carcinoma (HCC) confers extremely poor prognosis. While lenvatinib plus tislelizumab is an active targeted-immunotherapy regimen, local control of tumor thrombus remains suboptimal. Stereotactic body radiotherapy (SBRT) delivered…
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Artikel Jurnal
“Clinical outcomes of definitive interstitial/hybrid high-dose-rate and pulsed-dose-rate interventional radiotherapy (brachytherapy) for non-melanoma skin cancer: A single-center retrospective analysis”
Purpose: To evaluate clinical outcomes and toxicity of definitive interstitial or hybrid interventional radiotherapy (IRT; brachytherapy) using high-dose-rate (HDR) or pulsed-dose-rate (PDR) techniques for non-melanoma skin cancer (NMSC) unsuitable for standard superficial treatment. Materials and…
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Artikel Jurnal
Ablative magnetic resonance–guided radiation for gastrointestinal neuroendocrine tumors: assessing local control and toxicity
Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are an indolent subset of neuroendocrine neoplasms with a propensity to metastasize. In the case of oligoprogression, locoregional therapies are considered but may not be suitable for all patients. Stereotactic body radiotherapy…
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Artikel Jurnal
Ultrasound-responsive nanotherapy promotes axonal regeneration after SCI via reactivating CREB/miR-129-5p signaling
Spinal cord injury (SCI) remains a devastating neurological disorder with few effective therapeutic interventions due to the poor intrinsic regenerative capacity of adult central nervous system neurons. Here, we identified miR-129-5p as a downstream effector of cAMP-response element binding protein…
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Artikel Jurnal
Engineered probiotics couple photothermal cuproptosis with biomechanical disruption and immune activation
Living bacterial therapeutics face limitations from poor surface functionalization and a hostile tumor microenvironment. Here, we engineer EPACS (EcN@PDA/Au–CuS) by coating E. coli Nissle 1917 with polydopamine, which acts as an adhesive interfacial platform to direct the uniform in situ growth of…
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Artikel Jurnal
AI-enabled multi-class visual fault diagnosis for large-scale solar photovoltaic systems supporting energy transition and net-zero operations
Large-scale solar photovoltaic installations are required to have reliable inspection methodologies in order to detect surface conditions or degradation states which could negatively affect their operational efficiencies. In this paper, we develop a visual condition classification system for…
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Artikel Jurnal
Stress interference and propagation uniformity in multi cluster hydraulic fracturing using a coupled XFEM based CZM model
The uniform propagation of multiple hydraulic fractures is crucial to maximize the volume of stimulated reservoirs and improve the recovery of hydrocarbons in unconventional reservoirs. However, simultaneous fluid injections often result in non-uniform fracture growth due to strong stress…
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Artikel Jurnal
Experiences of after-dark urban forest walks when using head torches: off-the-shelf vs customised
During the dark season, electric lighting in urban forests can facilitate recreational activities and psychological restoration. However, the permanent presence of electric lighting causes light pollution, with detrimental effects for people and wildlife. This study explored the extent to which…
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Artikel Jurnal
A generative design tool for designing the physical elements of communities
This research examines the use of generative design (GD) for neighbourhood design, specifically to optimize land use distribution and road networks. Neighbourhood design is inherently complex, involving trade-offs among accessibility, land use diversity, and stakeholder engagement. Traditional…
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Artikel Jurnal
Factors affecting public transport adoption in Riyadh- case study
Riyadh's greenhouse gas emissions and urban climate risks are likely heightened by accelerated urbanization and profound dependence on private cars. Despite the government's investment in public transportation, societal resistance to giving up private cars and using public transit persists due to…
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Artikel Jurnal
In situ bioactive nanocoating enables transocular delivery of permeable drug for dual-location intervention of ocular surface and fundus disorders
The concurrency of ocular surface and fundus disorders is prevalent, posing a major threat to vision and quality of life. However, current therapies are difficult to simultaneously manage these coexisting symptoms. Here, we report a dual-location intervention strategy by in situ forming a permeable…
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Artikel Jurnal
Global burden and inequalities of Hodgkin and non-Hodgkin lymphoma among children aged 0–14 years, 1990–2021: a GBD 2021 analysis with forecasts to 2035
Objective: Childhood Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) are potentially curable, but outcomes differ across development levels. The authors assessed global burden and inequalities among children aged 0–14 years from 1990 to 2021 and projected burden to 2035. Methods: GBD 2021…
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Artikel Jurnal
Asymmetric loop seal clearing and reformation during a shutdown-cooling LOCA with single-loop passive cooling: ATLAS integral effect test and MARS-KS assessment
A loss-of-coolant accident (LOCA) initiated from a shutdown-cooling condition (shutdown-cooling LOCA) was investigated in the ATLAS integral effect test facility as the C4.2 test of the OECD-ATLAS3 joint project. The test simulated a 50 % direct vessel injection (DVI) line break of APR1400, with…
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Artikel Jurnal
A variable-domain integral weak solution deep learning method for neutron diffusion calculations in multi-material domains
Neutron diffusion calculations are an important part of reactor physics analysis. In reactor models involving multi-material domains, diffusion coefficients and macroscopic cross sections are typically defined piecewise. Their discontinuities at material interfaces result in discontinuous neutron…
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Artikel Jurnal
Experimental investigation of damage mechanisms and limit states for nuclear power plant electrical cabinets using tri-axial shaking table tests
Seismic fragility tests using tri-axial shaking table excitation were performed on representative safety-related electrical cabinets for nuclear power plants, namely two MCCs, two switchgears, an inverter, a battery charger, and a load center, to evaluate their ultimate limit states and dynamic…
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Artikel Jurnal
Factor effect analyses on radionuclide release rate from a spent nuclear fuel transport cask submerged in deep sea for surrogate model development
In Korea, maritime transportation of spent nuclear fuel (SNF) is considered as a highly plausible management option. It is necessary to develop technology to assess the radiological impact of SNF cask submersion accidents to manage the risk caused by the maritime transportation of SNF and to find…
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Artikel Jurnal
Automating real-time recovery from radiation-induced errors with byte-sized corrections
Radiation-induced errors in high-energy physics detectors threaten data integrity and uptime, posing significant challenges for reliable operation during the future high-luminosity LHC runs. With over 150,000 ASICs to be deployed in the CMS HGCAL front-end, even a very low per-chip error…
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Artikel Jurnal
Few-shot class-incremental fault diagnosis in nuclear power plants via a static network-based method
The operational safety of nuclear power plants (NPPs) imposes a lifelong adaptability requirement on fault diagnosis systems: they must recognize newly emerging fault types from very limited samples while retaining diagnostic performance on previously learned faults. However, conventional…
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Artikel Jurnal
Generation time in a discrete epidemic model with asymptomatic carriers: beyond geometric waiting times
We study the random times between successive cases in a transmission chain of infectious diseases with asymptomatic carriers. We derive the probability distribution of this generation time (in days) from a discrete-time epidemic model with variable infectiousness both along elapsed times and across…
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