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Journal Article
Clause-level structural alignment between ASME Section III and Czech NTD A.S.I. Section III: Domain- and component-resolved assessment
Comparative studies of nuclear pressure-boundary component design codes have focused mainly on selected provisions and governing equations, but domain- and component-resolved clause-level quantification between ASME Section III and NTD A.S.I. Section III has not been systematically reported. This…
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Journal Article
Technical challenges and operational milestones in scaling proton beam current for tandem accelerator-based BNCT
High-current electrostatic tandem accelerators are considered a key technology for the development of compact hospital-based neutron sources for Boron Neutron Capture Therapy (BNCT). By employing charge-exchange stripping and SF 6 -gas insulation, these accelerator systems can efficiently generate…
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Journal Article
Modeling of the high burnup structure formation in UO
A bubble pressure-based model was developed to predict the formation of high burnup structure (HBS) in nuclear fuel pellets. In contrast to existing models that predominantly focus on burnup, the proposed model comprehensively considers physically relevant parameters, including fission gas…
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Journal Article
Effects of microstructure fraction on
SA508 low-alloy steel is a candidate material for main steam line piping, and its microstructure and mechanical properties are significantly influenced by the cooling rate after austenitizing. This study quantitatively analyzed the effect of cooling rate–induced microstructural changes on J -R…
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Journal Article
Impact of depletion chain files on isotopic prediction accuracy in OpenMC: Analysis of Fukushima Daini Unit 1 BWR using SFCOMPO data
This study evaluates the impact of depletion chain files on the isotopic prediction accuracy of OpenMC using post-irradiation examination data from five BWR 9×9-9 fuel samples irradiated in Fukushima Daini Unit 1. Six depletion chain files—ENDF/B-VII.1, ENDF/B-VIII.0, ENDF/B-VIII.1, JEFF-4.0…
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Journal Article
From trust to retirement preparedness: the mediating role of financial behavior and financial resilience
Population ageing and demographic shifts in the European Union are placing increasing strain on traditional pension systems, shifting greater responsibility to individuals to ensure their own retirement preparedness. In this context, identifying factors that strengthen individuals’ confidence in…
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Journal Article
Use of a Medial Femoral Condyle Free Flap for Metacarpal Reconstruction of Type IIIC Congenital Thumb Hypoplasia
This is a case report of a 14-year-old girl with a Blauth Type IIIc hypoplastic thumb who underwent metacarpal reconstruction with a medial femoral condyle flap to preserve a five-digit hand. At the patient’s 9-month follow-up, imaging demonstrated complete bone healing at both the first metacarpal…
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Journal Article
Informal urban regeneration through social capital: The Anousheh Street experience in a developing city
While underprivileged neighborhoods are often seen as obstacles to urban development, their regeneration is essential for achieving sustainable urban development. Understanding the factors that influence successful regeneration experiences can guide action in similar neighborhoods. This study…
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Journal Article
Role-specific household contact patterns in urban and rural China: Implications for influenza household transmission
Background: Household contact patterns significantly influence the household transmission dynamics of respiratory pathogens. Previous studies have shown ignoring the heterogeneity of household contact patterns can lead to an underestimation of the relative susceptibility and infectivity of children…
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Journal Article
Reirradiation of recurrent brain tumors: a review by the ESTRO CNS Focus Group
Purpose: Reirradiation has become an area of increasing clinical and scientific interest, particularly in neuro-oncology. This non-systematic review on central nervous system (CNS) tumors by the CNS focus group of the European Society for Radiotherapy and Oncology provides a pragmatic synthesis of…
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Journal Article
The value of community engagement in the ESTRO–EORTC OligoCare project: A quantification of the in-kind contributions
Background: The OligoCare cohort constitutes the largest prospective dataset evaluating metastasis-directed radiotherapy in oligometastatic disease worldwide. Although the project received financial support for central coordination, no financial compensation for the operational involvement of the…
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Journal Article
MR-guided ultra-hypofractionated radiotherapy for early-stage glottic cancer: A phase I feasibility study
Introduction: Ultra-hypofractionation for early-stage glottic cancer reduces the number of hospital visits, but requires precise delivery to minimize the risk of radiation-induced toxicity. Magnetic Resonance (MR)-guided radiotherapy is a delivery technique that enables visualization of the tumor…
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Journal Article
A vaccination model for COVID-19 with asymptomatic transmission, waning immunity, and outbreak calibration
The COVID-19 pandemic has posed unprecedented challenges to global public health, revealing critical gaps in our understanding of transmission dynamics, particularly the roles of asymptomatic spread and waning immunity. To address these gaps, we develop a mathematical model of COVID-19 transmission…
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Journal Article
Photocatalytic CO
Photocatalytic CO 2 reduction is an appealing approach for producing value-added chemicals and fuels from greenhouse gases. However, it faces challenges because of low activity, poor selectivity, and catalyst instability. Heterojunction engineering is a viable approach to improve charge-carrier…
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Journal Article
Radiation dose analysis in the lithium system rooms during beam-on and beam-off
International Fusion Materials Irradiation Facility – DEMO-Oriented NEutron Source (IFMIF-DONES) is a d–Li neutron irradiation facility developed, which is being designed as part of the European roadmap to fusion-generated electricity. This work presents shielding analyses to support the design of…
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Journal Article
Aptamer-functionalized EGCG nanocarrier for neutrophil-targeted AKBA delivery promotes anxiety-related fracture healing
Anxiety is clinically associated with impaired fracture healing, but the underlying immunological mechanism remains unclear, and no targeted therapy is available. In a mouse model of chronic restraint stress (CRS)-induced anxiety with femoral fracture, we observed expansion of TGFβ1 + CCR5 +…
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Journal Article
Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating
The extracellular matrix (ECM) undergoes extensive architectural remodeling during tumor progression, generating nanoscale alignment cues that profoundly influence behaviors of immune cells. However, whether ECM nanoarchitecture directly programs their immune secretory functions remains poorly…
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Journal Article
Efineptakin alfa (NT-I7) improves overall survival and induces immune niches in murine tumors
Tertiary lymphoid structures (TLSs) are emerging as good predictive biomarkers of response to cancer immunotherapy. However, therapeutic strategies to induce these structures are currently limited. We evaluated the therapeutic benefit of efineptakin alfa (NT-I7), a long-acting form of IL-7, as well…
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Journal Article
VCP at the crossroads of UPS and autophagy in cancer
Proteostasis is maintained by the coordinated action of the ubiquitin–proteasome system (UPS) and autophagy–lysosome pathways. Valosin-containing protein (VCP/p97), an AAA + unfoldase, sits at its intersection by extracting ubiquitinated clients and assembling cofactor-defined complexes that…
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Journal Article
Rewiring redox defense: Nrf2-driven antioxidant signaling as a gateway to programmed cell death activation in colorectal cancer
Nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidant and phase II detoxification genes, plays a dual role in colorectal cancer (CRC) progression by maintaining redox homeostasis while paradoxically fostering chemoresistance. Programmed cell death (PCD) pathways…
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