50 hasil untuk "Li-Ang Lee"

Combined laryngopharyngeal reflux and obstructive sleep apnea (CLOSA) – Salivary pepsin test for laryngopharyngeal reflux in obstructive sleep apnea patients

Shih-Chieh Shen; Yen-Ting Chiang; Liang-Wei Tseng dkk.

Tzu Chi Medical Journal, Vol. 37 No. 4 · 2025 · Inggris · DOAJ Scopus

Objectives: Reflux disease including gastroesophageal reflux and laryngopharyngeal reflux (LPR) is often found in obstructive sleep apnea (OSA) patients. Endoscopic examination is a gold standard diagnosis for reflux disease. However, the invasive procedure limits its widespread use. The…

Influenza A Virus PB1-F2 Gene in Recent Taiwanese Isolates

Guang-Wu Chen; Ching-Chun Yang; Kuo-Chien Tsao dkk.

Emerging Infectious Diseases, Vol. 10 No. 4 · 2004 · Inggris · DOAJ Scopus

Influenza A virus contains eight RNA segments and encodes 10 viral proteins. However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1). This novel protein is translated from an alternative open reading frame (ORF) in the PB1 gene. We analyzed the PB1 gene of 42 recent…

Palatal hybrid surgery for obstructive sleep apnea-state-of-the-art annotation of uvulopalatopharyngoplasty

Hsueh-Yu Li; Ming-Shao Tsai; Li-Ang Lee dkk.

Biomedical Journal, Vol. 46 No. 3 · 2023 · Inggris · DOAJ Scopus

Background: Surgery for obstructive sleep apnea (OSA) has changed in concept and technique that transformed from radical excision to functional reconstruction. The aim of this study was to investigate the safety and effectiveness of palatal hybrid surgery in OSA patients. Methods: Palatal hybrid…

Human papillomavirus infection is not associated with laryngeal squamous cell carcinoma in Taiwan

Chung-Guei Huang; Li-Ang Lee; Tuan-Jen Fang dkk.

Journal of Microbiology, Immunology and Infection, Vol. 53 No. 1 · 2020 · Inggris · DOAJ Scopus

Background/Purpose: To examine whether the prevalence rate of human papillomavirus (HPV) infection in Taiwanese patients with primary laryngeal squamous cell carcinoma (LSCC) is different from that in those with a vocal polyp (VP) or vocal fold leukoplakia (VFL). Methods: This prospective cohort…

Intrapharyngeal surgery with integrated treatment for obstructive sleep apnea

Hsueh-Yu Li; Li-Ang Lee; Li-Jen Hsin dkk.

Biomedical Journal, Vol. 42 No. 2 · 2019 · Inggris · DOAJ Scopus

Obstructive sleep apnea (OSA) is a common disease in adults, which influences human relations, quality of life and associates with major complications. Continuous positive airway pressure (CPAP) is the gold standard treatment modality in OSA patients. For patients incompliant or unwilling to CPAP…

Prevalence and effects of sleep-disordered breathing on middle-aged patients with sedative-free generalized anxiety disorder: A prospective case-control study

Tien-Yu Chen; Yen-Ying Kung; Hsiao-Ching Lai dkk.

Frontiers in Psychiatry, Vol. 13 · 2023 · Inggris · DOAJ Scopus

ObjectiveGeneralized anxiety disorder (GAD) and sleep-disordered breathing (SDB) share similar symptoms, such as poor sleep quality, irritability, and poor concentration during daily activities. This study aims to investigate the proportion of undiagnosed SDB and its impacts on anxiety severity and…

Prognostic impact of extratumoral perineural invasion in patients with oral cavity squamous cell carcinoma

Li‐Yu Lee; Dante De Paz; Chien‐Yu Lin dkk.

Cancer Medicine, Vol. 8 No. 14 · 2019 · Inggris · DOAJ Scopus

Abstract Purpose Perineural invasion (PNI) is an adverse prognostic factor in patients with oral cavity squamous cell carcinoma (OCSCC). The American Joint Committee on Cancer Staging Manual, eighth edition, introduced a subdivision of PNI into two distinct forms, that is, extratumoral and…

Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review

Li-Jen Hsin; Hai-Hua Chuang; Mu-Yun Lin dkk.

Microorganisms, Vol. 9 No. 6 · 2021 · Inggris · DOAJ Scopus

Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the…

Energy types of snoring sounds in patients with obstructive sleep apnea syndrome: a preliminary observation.

Li-Ang Lee; Jen-Fang Yu; Yu-Lun Lo dkk.

PLoS ONE, Vol. 7 No. 12 · 2012 · Inggris · DOAJ Scopus

BACKGROUND: Annoying snore is the principle symptom and problem in obstructive sleep apnea syndrome (OSAS). However, investigation has been hampered by the complex snoring sound analyses. OBJECTIVE: This study was aimed to investigate the energy types of the full-night snoring sounds in patients…

Oral presentation assessment and image reading behaviour on brain computed tomography reading in novice clinical learners: an eye-tracking study

Chi-Hung Liu; June Hung; Chun-Wei Chang dkk.

BMC Medical Education, Vol. 22 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Background To study whether oral presentation (OP) assessment could reflect the novice learners’ interpretation skills and reading behaviour on brain computed tomography (CT) reading. Methods Eighty fifth-year medical students were recruited, received a 2-hour interactive workshop on how…

A Portable Neck-Surface Piezoelectric Sensor for Evaluating Subclinical Carotid Atherosclerosis via Snoring Vibratory Analysis: An Exploratory Dual-Modality Study

Li-Ang Lee; Li-Pang Chuang; Guo-She Lee dkk.

Biosensors, Vol. 16 No. 8 · 2026 · Inggris · DOAJ Scopus

Obstructive sleep apnea syndrome (OSAS) is heavily implicated in subclinical cardiovascular disease; however, traditional polysomnographic metrics fail to capture the localized mechanical trauma exerted on the carotid artery. To address this methodological gap, this study evaluated exploratory…

Screening Severe Obstructive Sleep Apnea in Children with Snoring

Hui-Shan Hsieh; Chung-Jan Kang; Hai-Hua Chuang dkk.

Diagnostics, Vol. 11 No. 7 · 2021 · Inggris · DOAJ Scopus

Efficient screening for severe obstructive sleep apnea (OSA) is important for children with snoring before time-consuming standard polysomnography. This retrospective cross-sectional study aimed to compare clinical variables, home snoring sound analysis, and home sleep pulse oximetry on their…

Alterations in Gut Microbiota Composition Are Associated with Changes in Emotional Distress in Children with Obstructive Sleep Apnea

Chung-Guei Huang; Wan-Ni Lin; Li-Jen Hsin dkk.

Microorganisms, Vol. 12 No. 12 · 2024 · Inggris · DOAJ Scopus

Emerging evidence underscores the pivotal role of the gut microbiota in regulating emotional and behavioral responses via the microbiota–gut–brain axis. This study explores associations between pediatric obstructive sleep apnea (OSA), emotional distress (ED), and gut microbiome alterations before…

Role of flexible transnasal esophagoscopy and patient education in the management of globus pharyngeus

Chia-Chi Cheng; Tuan-Jen Fang; Ta-Jen Lee dkk.

Journal of the Formosan Medical Association, Vol. 111 No. 3 · 2012 · Inggris · DOAJ Scopus

Globus pharyngeus and dysphagia are common complaints of patients referred to ear, nose, and throat (ENT) clinics. We aimed to establish an efficient method to rule out the presence of malignancy in patients with globus pharyngeus and dysphagia. Methods: The use of flexible transnasal esophagoscopy…

Seeking Medical Assistance for Dysphonia Is Associated with an Improved Survival Rate in Laryngeal Cancer: Real-World Evidence

Yi-An Lu; Ming-Shao Tsai; Li-Ang Lee dkk.

Diagnostics, Vol. 11 No. 2 · 2021 · Inggris · DOAJ Scopus

(1) Background: Patients with laryngeal cancer usually present with dysphonia. However, some studies reported that the duration from dysphonia to cancer diagnosis has been prolonged significantly in recent years. This study aimed to evaluate that in the initial dysphonia-related diagnosis and the…

Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus

Sheng-Yu Huang; Chih-Heng Huang; Chi-Jene Chen dkk.

Molecular Therapy: Nucleic Acids, Vol. 17 · 2019 · Inggris · DOAJ Scopus

The role of microRNA (miRNA) in influenza A virus (IAV) host species specificity is not well understood as yet. Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated kinase (ERK) pathway upon IAV infection and is associated with increased viral titers in…

Human Papillomavirus-16 Infection in Advanced Oral Cavity Cancer Patients Is Related to an Increased Risk of Distant Metastases and Poor Survival

Li-Ang Lee; Chung-Guei Huang; Chun-Ta Liao dkk.

PLoS ONE, Vol. 7 No. 7 · 2012 · Inggris · PLOS Scopus

Background: Human papillomavirus (HPV) is an oncogenic virus causing oropharyngeal cancers and resulting in a favorable outcome after the treatment. The role of HPV in oral cavity squamous cell carcinoma (OSCC) remains ambiguous. Objective: This study aimed to examine the effect of HPV infection on…

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Using a 360° Virtual Reality or 2D Video to Learn History Taking and Physical Examination Skills for Undergraduate Medical Students: Pilot Randomized Controlled Trial

Yi-Ping Chao; Hai-Hua Chuang; Li-Jen Hsin dkk.

JMIR Serious Games, Vol. 9 No. 4 · 2021 · Inggris · DOAJ Scopus

BackgroundLearning through a 360° virtual reality (VR) or 2D video represents an alternative way to learn a complex medical education task. However, there is currently no consensus on how best to assess the effects of different learning materials on cognitive load estimates, heart rate variability…

Alterations of Gut Microbiome Composition and Function Pre- and Post-Adenotonsillectomy in Children with Obstructive Sleep Apnea

Hai-Hua Chuang MD; Li-Ang Lee MD, PhD; Li-Pang Chuang MD, PhD dkk.

Journal of Otolaryngology - Head and Neck Surgery, Vol. 53 · 2024 · Inggris · DOAJ Scopus

Importance Obstructive sleep apnea (OSA) in children is linked with alterations in the gut microbiome. The influence of adenotonsillectomy (AT), a primary intervention for OSA, on gut microbiota dynamics relative to disease severity remains to be elucidated. Objective This study aimed to…