31 hasil untuk "Alessandro Prete"
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Artikel Jurnal Teks lengkap
State of the Art in 3D Culture Models Applied to Thyroid Cancer
Thyroid cancer (TC) is the prevalent endocrine tumor with a rising incidence, particularly in higher-income countries, leading to an increased interest in its management and treatment. While overall, survival rates for TC are usually favorable, advanced cases, especially with metastasis and…
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Current best practice in the management of patients after pituitary surgery
Sellar and parasellar masses are a common finding, and most of them are treated surgically via transsphenoidal approach. This type of surgery has revolutionized the approach to several hypothalamic-pituitary diseases and is usually effective, and well-tolerated by the patient. However, given the…
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Sporadic Medullary Thyroid Carcinoma: Towards a Precision Medicine
Medullary thyroid carcinoma (MTC) is a neuroendocrine malignant tumor originating from parafollicular C-cells producing calcitonin. Most of cases (75%) are sporadic while the remaining (25%) are hereditary. In these latter cases medullary thyroid carcinoma can be associated (multiple endocrine…
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Iodine Supplementation: Usage “with a Grain of Salt”
Iodine supplementation through salt iodization is a worldwide, effective strategy for preventing iodine deficiency-related problems. Its safety and efficacy profile has been extensively investigated, and benefits far outweigh the potential iodine-induced risks. Moreover, iodine supplementation…
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Update on Fundamental Mechanisms of Thyroid Cancer
The incidence of thyroid cancer (TC) has increased worldwide over the past four decades. TC is divided into three main histological types: differentiated (papillary and follicular TC), undifferentiated (poorly differentiated and anaplastic TC), and medullary TC, arising from thyroid C cells. This…
Juga tersedia di: DOAJ
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Fluctuating obliterative bronchiolitis in RET-mutant medullary thyroid cancer patient treated with selpercatinib
Highly selective RET inhibitor selpercatinib has demonstrated notable efficacy in advanced/progressive RET-mutant medullary thyroid cancer (MTC) patients. However, despite a more tolerable toxicity profile than multikinase inhibitors, peculiar adverse events (AEs) have been described. Obliterative…
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Comprehensive Quantitative Urinary Steroid Profiling of 29 Steroids Using Liquid Chromatography‐Tandem Mass Spectrometry
ABSTRACT Steroids are critical for numerous physiological processes; disruption in their metabolism is associated with numerous endocrine disorders. Steroid quantification is essential to improve the understanding and diagnosis of these pathologies. Historically, urinary steroid profiling has been…
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Adrenal tumour diagnostic pathway: findings from a national survey in the United Kingdom
Background: Currently, there is very limited information on referral patterns, diagnostic workup, and management of adrenal tumours (ATs) across secondary and tertiary endocrine centres in the UK. Objective: To evaluate current practices in assessing and managing ATs across the UK, including…
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Artikel Jurnal Teks lengkap
Insights into Ultrasound Features and Risk Stratification Systems in Pediatric Patients with Thyroid Nodules
Thyroid nodules in pediatric patients are less common than in adults but show a higher malignancy rate. Accordingly, the management of thyroid nodules in pediatric patients is more complex the younger the patient is, needing careful evaluation by physicians. In adult patients, specific ultrasound…
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The impact of estrogen status on the gut microbiome: a systematic review and meta-analysis
BackgroundEstrogens have been proposed as modulators of gut microbiome (GM) composition, yet evidence from observational studies remains inconsistent.ObjectiveThis meta-analysis aimed to systematically summarise existing evidence on GM alterations in hypoestrogenic women – post-menopausal or…
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Usefulness of second 131I treatment in biochemical persistent differentiated thyroid cancer patients
Background: Second 131I treatment is commonly performed in clinical practice in patients with differentiated thyroid cancer and biochemical incomplete or indeterminate response (BiR/InR) after initial treatment. Objective: The objective of the is study is to evaluate the clinical impact of the…
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Impact of coronavirus disease 2019 on patients with primary adrenal insufficiency: a cross-sectional study
Objective: Patients with primary adrenal insufficiency (PAI) are thought to be particularly vulnerable to coronavirus disease 2019 (COVID-19); however, little is known about its true impact on this group. We assessed morbidity and health promotion attitudes during the pandemic amongst a large…
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A case of unilateral post-COVID-19 adrenal haemorrhage and follow-up during pregnancies
The spectrum of endocrine-related complications of COVID-19 infection is expanding; one of the most concerning of which is adrenal haemorrhage due to the risk of catastrophic adrenal crisis. In this study, we present a case that highlights the challenging management of a large, indeterminate…
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Multifocality and bilaterality in medullary thyroid cancer: basis for a proof-of-concept safety of lobectomy
OBJECTIVE: At present, total thyroidectomy and central neck dissection are the surgical approaches recommended for the initial treatment of medullary thyroid cancer (MTC) independently of the size, number of tumor foci, age of patients, and other demographic and clinico–pathological parameters. The…
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Bilateral testicular metastases of medullary thyroid carcinoma in an adult male with multiple endocrine neoplasia 2A syndrome: case report and review of literature
Introduction: Medullary thyroid cancer (MTC) is a rare endocrine tumor, which can be sporadic or familial, as a component of multiple endocrine neoplasia 2 (MEN2). Overall, 10% of MTC cases have already developed at presentation or will develop metastasis during follow-up. Testicular metastases are…
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Artikel Jurnal Teks lengkap
Higher RET Gene Expression Levels Do Not Represent anAlternative RET Activation Mechanism in Medullary Thyroid Carcinoma
This study was designed to investigate whether RET (rearranged during transfection) mRNA over-expression could be considered an alternative driver event for the development of medullary thyroid carcinoma (MTC), and if different RET isoforms could play a role in MTC tumorigenesis. Eighty-three MTC…
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RET mutated C-cells proliferate more rapidly than non-mutated neoplastic cells
A statistically significant higher prevalence of the RET p.Met918Thr somatic mutation, identified by direct sequencing, was previously reported in MTC > 2 cm than in smaller tumors. Aim of this study was to correlate the full RET and RAS mutation profile, identified by a Next Generation Sequencing…
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Active surveillance for a small low-risk papillary thyroid cancer: a 10-year prospective, observational study in an Italian tertiary care centre
Objective To evaluate the long-term safety and feasibility of active surveillance (AS) for Italian patients with low-risk papillary thyroid microcarcinoma (mPTC) and to analyse trends in patient enrolment and factors associated with discontinuation of surveillance. This study represents the first…
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Firm mass in thyroid of an elderly patient: not always cancer
In elderly patients presenting with a solid thyroid mass, the differential diagnosis between benign and malignant lesion is not always straightforward. We present the case of an 85-year-old woman with fever and an enlarged, firm and painful thyroid mass. Blood exams documented a mild thyrotoxicosis…