23 results for "Benjamin Lin"

Editorial: Establishing and Maintaining Cell Polarity

Benjamin Lin; Zhiyi Lv; Yi Wu

Frontiers in Cell and Developmental Biology, Vol. 9 · 2021 · English · DOAJ Scopus

Attending Perceptions on the Use of Preference Signaling in the Ophthalmology Residency Application Process

Geoffrey Nguyen; Benjamin Lin; Jayanth Sridhar et al.

Journal of Academic Ophthalmology, Vol. 15 No. 02 · 2023 · English · DOAJ

Objective This article characterizes perspectives of ophthalmologists involved in the residency selection process regarding the potential impact of preference signaling on the ophthalmology residency match.

Complex effects of kinase localization revealed by compartment-specific regulation of protein kinase A activity

Rebecca LaCroix; Benjamin Lin; Tae-Yun Kang et al.

eLife, Vol. 11 · 2022 · English · DOAJ

Kinase activity in signaling networks frequently depends on regulatory subunits that can both inhibit activity by interacting with the catalytic subunits and target the kinase to distinct molecular partners and subcellular compartments. Here, using a new synthetic molecular interaction system, we…

LncRNA Jpx induces Xist expression in mice using both trans and cis mechanisms.

Sarah Carmona; Benjamin Lin; Tristan Chou et al.

PLoS Genetics, Vol. 14 No. 5 · 2018 · English · DOAJ Scopus

Mammalian X chromosome dosage compensation balances X-linked gene products between sexes and is coordinated by the long noncoding RNA (lncRNA) Xist. Multiple cis and trans-acting factors modulate Xist expression; however, the primary competence factor responsible for activating Xist remains a…

Also available at: PLOS

Modelling cell polarization driven by synthetic spatially graded Rac activation.

William R Holmes; Benjamin Lin; Andre Levchenko et al.

PLoS Computational Biology, Vol. 8 No. 6 · 2012 · English · DOAJ Scopus

The small GTPase Rac is known to be an important regulator of cell polarization, cytoskeletal reorganization, and motility of mammalian cells. In recent microfluidic experiments, HeLa cells endowed with appropriate constructs were subjected to gradients of the small molecule rapamycin leading to…

Also available at: PLOS

Autoimmune Implications in a Patient with Graves’ Hyperthyroidism, Pre-eclampsia with Severe Features, and Primary Aldosteronism

Benjamin Lin; Lauren Robinson; Basem Soliman et al.

Medicina, Vol. 60 No. 1 · 2024 · English · DOAJ Scopus

Background and Objectives: Graves’ disease (GD) and primary aldosteronism (PA) are two pathologies that can cause significant morbidity and mortality. GD is mediated by autoantibodies, and recent studies have shown autoantibody involvement in the pathophysiology behind both PA and pre-eclampsia…

Removal of an infected pulmonary artery fibroelastoma disguised as a presentation of pulmonary embolism using a percutaneous suction thrombectomy device

Daemar H. Jones, MS; Benjamin Lin, BA; David Brabham, DO et al.

Journal of Vascular Surgery Cases and Innovative Techniques, Vol. 9 No. 4 · 2023 · English · DOAJ Scopus

Papillary fibroelastoma (PFE) is a rare, often benign, tumor originating typically in the endocardium and valves, with a preference for the left side of the heart. Although PFEs can appear asymptomatic, in the setting of embolization, they can lead to stroke, acute limb ischemia, and/or mesenteric…

Linking Chromosomal Silencing With Xist Expression From Autosomal Integrated Transgenes

Ikrame Naciri; Benjamin Lin; Chiu-Ho Webb et al.

Frontiers in Cell and Developmental Biology, Vol. 9 · 2021 · English · DOAJ Scopus

Xist is the master regulator of X-Chromosome Inactivation (XCI), the mammalian dosage compensation mechanism that silences one of the two X chromosomes in a female cell. XCI is established during early embryonic development. Xist transgene (Tg) integrated into an autosome can induce transcriptional…

Computerized metric assessment of glandular tissue volume within the peripheral zone of the prostate using combined magnetic resonance imaging and histopathology: Possible pathophysiological implications on prostate cancer development

John M. Wolpert; Caroline Presson; Nathaniel Kimball et al.

Investigative and Clinical Urology, Vol. 65 No. 4 · 2024 · English · DOAJ Scopus

"Purpose: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are prevalent urological ailments in elderly males. Numerous clinical studies have revealed an invert association between BPH/prostate size and PCa growth. This study investigates the association between prostate size and total…

Perceptions of a Virtual Interview Exercise for Ophthalmology Residency Applicants

Bilal Ahmed; Victoria Ly; Ankur Parikh et al.

Journal of Academic Ophthalmology, Vol. 13 No. 02 · 2021 · English · DOAJ

Importance In-person interviews have traditionally been considered a crucial component of the residency application process. Virtual interviews (VIs) became the standard format for the 2020 to 2021 application cycle due to the novel coronavirus disease 2019 (COVID-19) pandemic. VIs offer a new…

Comprehensive assessment of NR ligand polypharmacology by a multiplex reporter NR assay

Alexander Medvedev; Matt Moeser; Liubov Medvedeva et al.

Scientific Reports, Vol. 12 No. 1 · 2022 · English · DOAJ Scopus

Abstract Nuclear receptors (NR) are ligand-modulated transcription factors that regulate multiple cell functions and thus represent excellent drug targets. However, due to a considerable NR structural homology, NR ligands often interact with multiple receptors. Here, we describe a multiplex…

Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastoma

Hasan Alrefai; Benjamin Lin; Amr Elkholy et al.

Acta Neuropathologica Communications, Vol. 13 No. 1 · 2025 · English · DOAJ Scopus

Abstract Tumor-associated macrophages (TAMs) are the most abundant non-cancerous cell type in glioblastoma (GBM) and heavily influence GBM biology, contributing to tumor progression, therapeutic resistance, immune evasion, and neovascularization. Current in vitro models that utilize IL-4/IL-13…

Impaired Skeletal Muscle Regeneration in the Absence of Fibrosis during Hibernation in 13-Lined Ground Squirrels

Eva Andres-Mateos; Rebeca Mejias; Arshia Soleimani et al.

PLoS ONE, Vol. 7 No. 11 · 2012 · English · PLOS Scopus

Skeletal muscle atrophy can occur as a consequence of immobilization and/or starvation in the majority of vertebrates studied. In contrast, hibernating mammals are protected against the loss of muscle mass despite long periods of inactivity and lack of food intake. Resident muscle-specific stem…

Also available at: DOAJ

Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice

Anna K. Cook; Benjamin Lin; Yumo Song et al.

Neurobiology of Disease, Vol. 227 · 2026 · English · DOAJ Scopus

Loss-of-function progranulin (GRN) mutations cause frontotemporal dementia with TDP-43 pathology (FTD-TDP). Nearly all pathogenic GRN mutations cause progranulin haploinsufficiency, but it is unclear how progranulin insufficiency causes FTD-TDP. To address this question, we crossed…

Activation of serum/glucocorticoid‐induced kinase 1 (SGK1) is important to maintain skeletal muscle homeostasis and prevent atrophy

Eva Andres‐Mateos; Heinrich Brinkmeier; Tyesha N. Burks et al.

EMBO Molecular Medicine, Vol. 5 No. 1 · 2012 · English · DOAJ Scopus

Abstract Maintaining skeletal muscle mass is essential for general health and prevention of disease progression in various neuromuscular conditions. Currently, no treatments are available to prevent progressive loss of muscle mass in any of these conditions. Hibernating mammals are protected from…

Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma

Benjamin Lin; Abigail K. Shelton; Erin Smithberger et al.

Acta Neuropathologica Communications, Vol. 13 No. 1 · 2025 · English · DOAJ Scopus

Abstract GBM is an aggressive primary malignant brain tumor that has a poor prognosis. Molecular characterization of GBM has shown that EGFR mutations are present in over 50% of tumors. However, EGFR inhibitors have not shown clinical efficacy in contrast to other EGFR-driven neoplasms due to the…

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Shelsey W. Johnson, MD; Michael A. Garcia, MD; Emily K. Q. Sisson, MA et al.

Critical Care Explorations, Vol. 10 No. 2 · 2022 · English · DOAJ Scopus

OBJECTIVES:. To describe hospital variation in use of “guideline-based care” for acute respiratory distress syndrome (ARDS) due to COVID-19. DESIGN:. Retrospective, observational study. SETTING:. The Society of Critical Care Medicine’s Discovery Viral Infection and RESPIRATORY ILLNESS UNIVERSAL…