41 hasil untuk "Christopher Butler"

Cellular senescence in brain aging and neurodegeneration: from molecular mechanisms to translational opportunities

Yahveth Cantero-Fortiz; Christopher Butler; Xavier Montalbán dkk.

Frontiers in Cellular Neuroscience, Vol. 20 · 2026 · Inggris · DOAJ Scopus

Aging remains the predominant risk factor for Alzheimer’s disease (AD) and other neurodegenerative disorders, yet the mechanisms linking systemic aging to brain dysfunction remain incompletely understood. Cellular senescence, a state of stable cell-cycle arrest coupled with metabolic and secretory…

Attention network dysfunction underlies memory impairment in posterior cortical atrophy

Michele Veldsman; Giovanna Zamboni; Christopher Butler dkk.

NeuroImage: Clinical, Vol. 22 · 2019 · Inggris · DOAJ Scopus

Accumulating evidence suggests that memory is impaired in posterior cortical atrophy (PCA), alongside the early and defining visual disorder. The posterior parietal cortex is a key region of pathology in PCA and memory impairment may be the result of dysfunction of parietally dependent network…

Genetic Marker Mice and Their Use in Understanding Learning and Memory

Mark Murphy; Yvette M. Wilson; Christopher Butler

Functional Brain Mapping and the Endeavor to Understand the Working Brain · 2013 · Inggris · IntechOpen

The Influence of Health Perception on Shoulder Outcome Measure Scores

Richard E. Hardy; Engin Sungur; Christopher Butler dkk.

Clinics in Shoulder and Elbow, Vol. 22 No. 4 · 2019 · Inggris · DOAJ Scopus

Background Patient reported outcome measures assess clinical progress from the patient’s perspective. This study explored the relationship between shoulder outcome measures (The Disability of the Arm, Shoulder and Hand [DASH], American Shoulder and Elbow Surgeons Standard Shoulder Assessment score…

Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation

Jean L. Rintoul; Christopher Butler; Robin O. Cleveland dkk.

Nature Communications, Vol. 17 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Non-invasive brain stimulation offers therapeutic potential without surgery, yet existing electrical approaches lack spatial precision due to the long wavelengths of electric fields. Here we demonstrate acoustoelectric neuromodulation, a nonlinear interaction between applied acoustic and…

Clinical trial methods for family medicine and primary care

Robert Mash; Bolatito B. Fatusin; Edith Madela-Mntla dkk.

African Journal of Primary Health Care & Family Medicine, Vol. 17 No. 2 · 2025 · Prancis · DOAJ Scopus

This article outlines the essential features of clinical trials for doctoral or early career researchers. The World Health Organization has recently emphasised the need for higher quality clinical trials, more trials from low- and middle-income countries, as well as primary care, more engagement…

Developing a data-enabled nudge intervention for childhood antibiotics in primary care: a qualitative study

Oliver Van Hecke; Aleksandra Borek; Christopher Butler dkk.

BJGP Open, Vol. 9 No. 1 · 2025 · Inggris · DOAJ Scopus

Background: Preschool children (aged ≤5 years) have the highest antibiotic prescribing rate in general practice, mostly for self-limiting acute respiratory tract infections (RTIs). Research from >250 000 UK children suggests that a child’s antibiotic history for RTI may be a good predictor for…

Respiratory tract infections (RTIs) in primary care: narrative review of C reactive protein (CRP) point-of-care testing (POCT) and antibacterial use in patients who present with symptoms of RTI

Christopher Butler; Carl Llor; Matthew Dryden dkk.

BMJ Open Respiratory Research, Vol. 7 No. 1 · 2020 · Inggris · DOAJ Scopus

Antimicrobial resistance (AMR) continues to be a global problem and continues to be addressed through national strategies to improve diagnostics, develop new antimicrobials and promote antimicrobial stewardship. Patients who attend general (ambulatory) practice with symptoms of respiratory tract…

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial

Christopher Butler; Ly-Mee Yu; Kay Wang dkk.

BMJ Open, Vol. 8 No. 5 · 2018 · Inggris · DOAJ Scopus

Lumping and Splitting of Distribution Models Across a Biogeographic Divide Informs the Conservation of an Imperiled Fluvial Fish

Briant D. Nguyen; Jenna Messick; Anthony W. Rodger dkk.

Ecology and Evolution, Vol. 15 No. 4 · 2025 · Inggris · DOAJ Scopus

ABSTRACT Freshwater fishes are among the most threatened taxa in the world. A major challenge for the conservation and management of threatened fishes is scarce information regarding life history, habitat requirements, and the drivers of declines. Species distribution models (SDMs) that leverage…

Lateral parietal contributions to memory impairment in posterior cortical atrophy

Samrah Ahmed; Clare Loane; Sara Bartels dkk.

NeuroImage: Clinical, Vol. 20 · 2018 · Inggris · DOAJ Scopus

Objective: Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterised by progressive impairment in visuospatial and perceptual function. Recent findings show that memory functioning can also be compromised early in the course of disease. In this study, we investigated the neural…

PRINCIPLE trial demonstrates scope for in-pandemic improvement in primary care antibiotic stewardship: a retrospective sentinel network cohort study

Simon de Lusignan; Mark Joy; Julian Sherlock dkk.

BJGP Open, Vol. 5 No. 5 · 2021 · Inggris · DOAJ Scopus

Background: The Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE) has provided in-pandemic evidence that azithromycin and doxycycline were not beneficial in the early primary care management of coronavirus 2019 disease (COVID-19). Aim: To explore the extent of…

Advancing preparedness for clinical research during infectious disease epidemics

Nina Gobat; John Amuasi; Yazdan Yazdanpanah dkk.

ERJ Open Research, Vol. 5 No. 2 · 2019 · Inggris · DOAJ Scopus

Picture This: A Review of Research Relating to Narrative Processing by Moving Image Versus Language

Elspeth Jajdelska; Miranda Anderson; Christopher Butler dkk.

Frontiers in Psychology, Vol. 10 · 2019 · Inggris · DOAJ Scopus

Reading fiction for pleasure is robustly correlated with improved cognitive attainment and other benefits. It is also in decline among young people in developed nations, in part because of competition from moving image fiction. We review existing research on the differences between reading or…

Comparing dedicated and designated models of integrating mental health into chronic disease care: study protocol for a cluster randomized controlled trial

Bronwyn Myers; Crick Lund; Carl Lombard dkk.

Trials, Vol. 19 No. 1 · 2018 · Inggris · DOAJ Scopus

Abstract Background In low- and middle-income countries (LMIC), it is uncertain whether a “dedicated” approach to integrating mental health care (wherein a community health worker (CHW) has the sole responsibility of delivering mental health care) or a “designated” approach (wherein a CHW provides…

The impact of the COVID-19 lockdown on HIV care in 65 South African primary care clinics: an interrupted time series analysis

Jienchi Dorward; Thokozani Khubone; Kelly R. Gate dkk.

The Lancet HIV · 2021 · Inggris · OpenAlex Scopus

BACKGROUND: The effect of the COVID-19 pandemic on HIV outcomes in low-income and middle-income countries is poorly described. We aimed to measure the impact of the 2020 national COVID-19 lockdown on HIV testing and treatment in KwaZulu-Natal, South Africa, where 1·7 million people are living with…

The importance of appropriate selection of clinical endpoints in outpatient COVID-19 clinical trials

Kristian Thorlund; Davey Smith; Christopher Linsell dkk.

Communications Medicine, Vol. 3 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract Clinical trial endpoints must be carefully and intentionally selected so that the results of the trial can be used to inform policy- and decision-making. The relative importance of potential endpoints often depends on the stakeholder, with patients having different preferences to…

Long-term outcomes of urinary tract infection (UTI) in childhood: The LUCI study

Kathryn Hughes; Rebecca Cannings-John; Hywel Jones dkk.

International Journal of Population Data Science, Vol. 4 No. 3 · 2019 · Inggris · DOAJ Scopus

Background Guidelines recommend the prompt diagnosis and treatment of UTI in young children to reduce the risk of renal scarring and possible long-term complications. However, the evidence for this association is weak and has been questioned. There is an urgent need to clarify this as the correct…

Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome

Samrah Ahmed; Muireann Irish; Clare Loane dkk.

NeuroImage: Clinical, Vol. 18 · 2018 · Inggris · DOAJ Scopus

Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria describe relative sparing of episodic memory function, but recent findings…

Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Christopher Butler; Samuel Sprowls; Gabor Szalai dkk.

Translational Oncology, Vol. 13 No. 6 · 2020 · Inggris · DOAJ Scopus

Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of brain…