22 hasil untuk "Francesca Coperchini"

Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?

Mario Rotondi; Francesca Coperchini; Francesco Latrofa dkk.

Frontiers in Endocrinology, Vol. 9 · 2018 · Inggris · DOAJ Scopus

Tumor-related inflammation does influence the biological behavior of neoplastic cells and ultimately the patient’s outcome. With specific regard to thyroid cancer, the issue of tumor-associated inflammation has been extensively studied and recently reviewed. However, the role of chemokines, which…

Editorial: Precision medicine: recent advances, current challenges and future perspectives

Oriana Awwad; Mamoun Ahram; Francesca Coperchini dkk.

Frontiers in Pharmacology, Vol. 15 · 2024 · Inggris · DOAJ Scopus

Interleukin-6, CXCL10 and Infiltrating Macrophages in COVID-19-Related Cytokine Storm: Not One for All But All for One!

Francesca Coperchini; Luca Chiovato; Mario Rotondi

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

SARS-COV-2 virus is responsible for the ongoing devastating pandemic. Since the early phase of the pandemic, the “cytokine-storm” appeared a peculiar aspect of SARS-COV-2 infection which, at least in the severe cases, is responsible for respiratory treat damage and subsequent multi-organ failure…

Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs

Alessia Greco; Francesca Coperchini; Laura Croce dkk.

Frontiers in Pharmacology, Vol. 14 · 2023 · Inggris · DOAJ Scopus

Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however there is a percentage of patients that do not respond or are refractory to common therapies. Thus new therapeutics strategies are required. In the past decade, drug repositioning…

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

Francesca Coperchini; Luca Chiovato; Laura Croce dkk.

Cytokine & Growth Factor Reviews · 2020 · Inggris · OpenAlex Scopus

Editorial: Further advances in understanding the endocrine cancer microenvironment

Francesca Coperchini; Rosa Marina Melillo; Mario Rotondi

Frontiers in Endocrinology, Vol. 13 · 2022 · Inggris · DOAJ Scopus

Thyroid disrupting effects of exposure to sunscreens: in vitro and in vivo evidence of the impact of organic UV-filters

Alessia Greco; Elena Franchi; Marco Denegri dkk.

Environmental Health, Vol. 24 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Background Ultraviolet radiation (UVR), primarily from sunlight, is a natural component of environmental exposure and can cause genomic damage, photoaging, and skin cancer. Sunscreens containing UV-filters are widely used to prevent these effects and are also found in many personal care…

Thyroid Disrupting Effects of Old and New Generation PFAS

Francesca Coperchini; Laura Croce; Gianluca Ricci dkk.

Frontiers in Endocrinology · 2021 · Inggris · OpenAlex Scopus

Per- and polyfluoroalkyl substances (PFAS) represent a group of synthetic compounds widely used in industry plants due to their low grade of degradation, surfactant properties, thermic and flame resistance. These characteristics are useful for the industrial production, however they are also…

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Do PFCAs drive the establishment of thyroid cancer microenvironment? Effects of C6O4, PFOA and PFHxA exposure in two models of human thyroid cells in primary culture

Francesca Coperchini; Alessia Greco; Laura Croce dkk.

Environment International, Vol. 187 · 2024 · Inggris · DOAJ Scopus

Background: Exposure to environmental pollutants is suspected to be one of the potential causes accounting for the increase in thyroid cancer (TC) incidence worldwide. Among the ubiquitous pollutants, per-polyfluoroalkyl substances (PFASs), were demonstrated to exert thyroid disrupting effects…

Case series of de novo occurrence of Graves’ disease following thermal ablation for benign thyroid nodules: an uncommon event that should be considered

Marsida Teliti; Beatrice Grillini; Isabella Chiardi dkk.

European Thyroid Journal, Vol. 14 No. 6 · 2025 · Inggris · DOAJ Scopus

Introduction: Thermal ablation (TA), including radiofrequency (RFA) and microwave ablation (MWA), is a widely used, minimally invasive alternative to surgery for benign thyroid nodules. While transient, self-limited thyrotoxicosis is a recognized effect of the procedure, the onset of Graves’…

Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis

Mario Rotondi; Francesca Coperchini; G. Ricci dkk.

Journal of Endocrinological Investigation · 2020 · Inggris · OpenAlex Scopus

PURPOSE: SARS-COV-2 is a pathogenic agent belonging to the coronavirus family, responsible for the current global world pandemic. Angiotensin-converting enzyme 2 (ACE-2) is the receptor for cellular entry of SARS-CoV-2. ACE-2 is a type I transmembrane metallo-carboxypeptidase involved in the…

Methyl and propylparaben elicit distinct thyroid-disrupting effects in a rat thyroid cell model

Alessia Greco; Francesca Coperchini; Elena Franchi dkk.

Emerging Contaminants, Vol. 11 No. 4 · 2025 · Inggris · DOAJ Scopus

Parabens, including methylparaben (MtP) and propylparaben (PrP), are synthetic preservatives commonly used in cosmetics and personal care products. Increasing evidence suggests that these compounds may act as endocrine-disrupting chemicals (EDCs), but their effects on thyroid function remain…

Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

Mario Rotondi; Francesca Coperchini; Oriana Awwad dkk.

Mediators of Inflammation, Vol. 2016 · 2016 · Inggris · DOAJ Scopus

CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid…

Relationship between maternal obesity and first-trimester TSH in women with negative anti-TPO antibodies

Laura Croce; Fausta Beneventi; Federica Ripepi dkk.

European Thyroid Journal, Vol. 13 No. 2 · 2024 · Inggris · DOAJ Scopus

Objective: Obesity is associated with increased thyroid-stimulating hormone (TSH) in non-pregnant subjects, but this phenomenon has not been fully characterized during pregnancy. Our aim was to evaluate the impact of BMI on first-trimester TSH in a wide cohort of pregnant women with negative…

Thyroid hormones modifications among COVID-19 patients undergoing pulmonary rehabilitation

Laura Croce; Elisabetta Zampogna; Francesca Coperchini dkk.

Frontiers in Endocrinology, Vol. 14 · 2023 · Inggris · DOAJ Scopus

IntroductionPatients with severe COVID-19 often experience long-lasting disabilities that can improve after pulmonary rehabilitation. Moreover patients with severe COVID-19 display thyroid function alterations due to a non-thyroidal illness syndrome (NTIS). The aim of our study was to evaluate…

Proficiency in performing radiofrequency ablation procedure for non-functioning benign thyroid nodules: a qualitative rather than quantitative matter

Spyridon Chytiris; Marsida Teliti; Laura Croce dkk.

Frontiers in Endocrinology, Vol. 15 · 2024 · Inggris · DOAJ Scopus

ObjectiveRadiofrequency ablation (RFA) is an emerging non-surgical treatment for benign thyroid nodules (BTN). Despite its proven safety profile, data on the learning curve (LC) required to achieve proficiency are still lacking.Materials and methodsThe first 179 RFA procedures performed by a single…

Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion

Francesca Coperchini; Alessia Greco; Laura Croce dkk.

Frontiers in Endocrinology, Vol. 13 · 2022 · Inggris · DOAJ Scopus

BackgroundVitamin D3 is largely involved in the regulation of calcium homeostasis. More recently, it was demonstrated that vitamin D exerts several beneficial effects against cancer progression through several mechanisms, including the reduction of cancer cells proliferation and migration. CXCL8…

Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study

Laura Croce; Rosaria Maddalena Ruggeri; Camilla Virili dkk.

European Thyroid Journal, Vol. 14 No. 1 · 2025 · Inggris · DOAJ Scopus

Objective: The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical…

The in vitro effects of Voghera sweet pepper on thyroid cancer cells: modulation of oxidative stress and pro-tumorigenic genes

Francesca Coperchini; Fabrizio De Luca; Alessia Greco dkk.

Frontiers in Nutrition, Vol. 12 · 2025 · Inggris · DOAJ Scopus

BackgroundVoghera pepper (VP) extracts were demonstrated to have anti-oxidant ability in several cell types.PurposeThis study aimed to assess whether VP-extracts could lower oxidative stress and modulate thyroid cancer (TC) cells behavior in vitro.MethodsExtracts were analyzed using the LC-DAD-MS…