35 hasil untuk "Hammad Ismail"

In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa

Shahid Naseem; Hammad Ismail

BMC Complementary Medicine and Therapies, Vol. 22 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Background Lactuca sativa is an edible plant commonly used by local communities to manage diabetes and stomach problems. Methods This work aimed to investigate the anti-oxidant, anticancer, antidiabetic and Anti-Alzheimer effects of hydroponically (HyL) and soil-grown (SoL) Lactuca sativa…

Moringa oleifera gum based silver and zinc oxide nanoparticles: green synthesis, characterization and their antibacterial potential against MRSA

Muhammad Irfan; Hira Munir; Hammad Ismail

Biomaterials Research, Vol. 25 No. 1 · 2021 · Inggris · DOAJ Scopus

Abstract Background Herein, we first time used the gum Moringa oleifera as reducing and capping agent for successful synthesis of silver nitrate and zinc oxide nanoparticles(NPs) through green synthesis approach. This study was aimed to check antibacterial activities of synthesized NPs against…

Influenza vaccination: vital shield against asthma exacerbations

Hammad Ismail; Muhammad Usman Baig; Maryam Nawaz

Journal of the Pakistan Medical Association, Vol. 75 No. 10 · 2025 · Inggris · DOAJ Scopus

Asthma is a chronic inflammatory disease of airways that worsens when exposed to certain risk factors such as chemical irritants and physical exertion. Influenza, commonly known as the flu, can worsen respiratory symptoms in asthma patients, leading to hospitalization and further exacerbation of…

Ethnopharmacological activity of Hedera nepalensis K. Koch extracts and lupeol against alloxan-induced type I diabetes

Waleed Javed Hashmi; Hammad Ismail; Laila Jafri dkk.

Brazilian Journal of Pharmaceutical Sciences, Vol. 56 · 2020 · Inggris · DOAJ Scopus

In this study, we investigated the protective effects of Hedera nepalensis crude extract, its fractions and lupeol in alloxan-induced diabetic rats. Lupeol and n-hexane (HNN) fraction significantly reduced the blood glucose level by increasing insulin level in time dependent manner, and also…

Synthesis, Characterization, Biological Evaluation and DNA Interaction Studies of 4-Aminophenol Derivatives: Theoretical and Experimental Approach

Bushra Rafique; Saima Kalsoom; Abdulrahim A. Sajini dkk.

Molecules, Vol. 27 No. 4 · 2022 · Inggris · DOAJ Scopus

In the present study, five 4-aminophenol derivatives (4-chloro-2-(((4-hydroxyphenyl)imino)methyl)phenol(S-1), 4-((4-(dimethylamino)benzylidene)amino)phenol(S-2), 4-((3-nitrobenzylidene)amino)phenol(S-3), 4-((thiophen-2-ylmethylene)amino)phenol(S-4) and 4-(((E)-3-phenylallylidene)amino)phenol(S-5))…

Synthesis, Characterization, and Pharmacological Evaluation of Selected Aromatic Amines

Hammad Ismail; Bushra Mirza; Ihsan-ul Haq dkk.

Journal of Chemistry, Vol. 2015 · 2015 · Inggris · DOAJ Scopus

Aromatic amines 1-amino-4-phenoxybenzene (A-1A), 2-(4-aminophenoxy) naphthalene (A-2A), and 1-(4-aminophenoxy) naphthalene (A-3A) were synthesized by the reduction of corresponding nitroaromatics with hydrazine monohydrate and Pd/C 5% (w/w). The newly synthesized compounds were characterized by…

New 1-octanoyl-3-aryl thiourea derivatives: Solvent-free synthesis, characterization and multi-target biological activities

Fayaz Ali Larik; Aamer Saeed; Pervaiz Ali Channar dkk.

Bangladesh Journal of Pharmacology, Vol. 11 No. 4 · 2016 · Inggris · DOAJ Scopus

An efficient solvent-free synthesis of a 10-member library of octanoyl linked substituted aryl thioureas was accomplished successfully. The octanoyl isothiocyanate was freshly prepared in excellent yield and purity by the reaction of potassium thiocyanate with octanoyl chloride followed by removal…

Cloning of maize chitinase 1 gene and its expression in genetically transformed rice to confer resistance against rice blast caused by Pyricularia oryzae

Sadaf Anwaar; Nyla Jabeen; Khawaja Shafique Ahmad dkk.

PLOS ONE, Vol. 19 No. 1 · 2024 · Inggris · PLOS Scopus

Fungal pathogens are one of the major reasons for biotic stress on rice (Oryza sativa L.), causing severe productivity losses every year. Breeding for host resistance is a mainstay of rice disease management, but conventional development of commercial resistant varieties is often slow. In contrast…

RETRACTED: Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer’s disease combined with insilico molecular docking

Hammad Ismail; Dania Khalid; Durdana Waseem dkk.

PLOS ONE, Vol. 18 No. 11 · 2023 · Inggris · PLOS Scopus

Objective: Berberis lycium is an indigenous plant of Pakistan that is known for its medicinal properties. In the current study, we investigated the anti-Alzheimer’s effect of berberine isolated from Berberis lycium. Methods: Root extract of B. lycium was subjected to acetylcholinesterase inhibition…

‘Breast Cancer Resistance Likelihood and Personalized Treatment Through Integrated Multiomics’

Sabba Mehmood; Muhammad Faheem; Hammad Ismail dkk.

Frontiers in Molecular Biosciences, Vol. 9 · 2022 · Inggris · DOAJ Scopus

In recent times, enormous progress has been made in improving the diagnosis and therapeutic strategies for breast carcinoma, yet it remains the most prevalent cancer and second highest contributor to cancer-related deaths in women. Breast cancer (BC) affects one in eight females globally. In 2018…

Antioxidant, analgesic and anti-inflammatory activities of in vitro and field-grown Iceberg lettuce extracts

Iqra Younus; Hammad Ismail; Chahat Batool Rizvi dkk.

Journal of Pharmacy & Pharmacognosy Research, Vol. 7 No. 5 · 2019 · Spanyol · DOAJ Scopus

Context: Iceberg lettuce is a nutrient rich edible crop containing vitamin B6, thiamin and folate. The increasing demand of natural products is moving the focus towards in vitro plant sources as factories for producing important secondary metabolites. Aims: To evaluate the activities of in vitro…

New Bioactive Heteroleptic Copper(II) Carboxylates: Structure, Enzymatic and DNA-Binding Studies

Afifa Mushtaq; Saqib Ali; Muhammad Nawaz Tahir dkk.

Acta Chimica Slovenica, Vol. 64 No. 2 · 2017 · Inggris · DOAJ Scopus

Two new binuclear O-bridged copper(II) carboxylates with chemical formulas [Cu2(3-ClC6H4CH2COO)4(phen)2] (1) and [Cu2(3-ClC6H4CH2COO)4(bipy)2] (2) where phen = 1,10-phenanthroline and bipy = 2,2′-bipyridine have been synthesized and characterized by FT-IR, UV-Visible spectroscopy, CHN analysis and…

Synthesis, Characterization and Biological Studies of Ether–Based Ferrocenyl Amides and their Organic Analogues

Sana Waseem Abbasi; Naveed Zafar Ali; Martin Etter dkk.

Crystals, Vol. 10 No. 6 · 2020 · Inggris · DOAJ Scopus

Ferrocenyl amides (FB1-FB13) and their organic analogues (BZ1-BZ13) were prepared by a low-temperature condensation method. Ferrocenyl amides were synthesised using 4-ferrocenylbenzoyl chloride and ether-based amines and diamines. Benzoyl chloride was used to synthesise organic analogues by…

Green Synthesis of Gold and Iron Nanoparticles for Targeted Delivery: An In Vitro and In Vivo Study

Beenish Khanzada; Nosheen Akthar; Muhammad Zeeshan Bhatti dkk.

Journal of Chemistry, Vol. 2021 · 2021 · Inggris · DOAJ Scopus

Nanotechnology has vast applications in almost all fields of science and technology. The use of medicinal plants for the synthesis of metallic nanoparticles has gained much attention nowadays. In the current research work, six medicinal plants were used for the synthesis of gold nanoparticles…

Environmental enrichment as a therapeutic strategy against methamphetamine induces depressive behaviors in mice

Hammad Ismail; Syed Abdul Rafay; Talha Yaseen dkk.

PLOS One, Vol. 20 No. 10 · 2025 · Inggris · PLOS Scopus

Methamphetamine (METH) abuse is associated with addiction, emotional dysregulation, motor impairments, cognitive deficits, and depressive symptoms, which are exacerbated by stress and social isolation. This study investigated the therapeutic potential of combined treatment and environmental…

Computational screening of Sophora flavescens phytochemicals as potential aromatase inhibitors: Molecular docking, ADMET, Network pharmacology, Molecular dynamics simulation, and DFT studies

Laiba Rashid; Jarin Tasnim; Md Mehedi Hasan dkk.

Pharmaceutical Science Advances, Vol. 4 · 2026 · Inggris · DOAJ Scopus

Breast cancer is one of the most prominent types of cancers and a leading cause of fatality in women throughout the world. It also contributes to abnormal estrogen production. The enzyme aromatase (CYP19A1), which catalyzes estrogen biosynthesis, regulates hormone-dependent breast cancer…

A decade of progress in rhizoengineering to exploit plant microbiome for salt stress amelioration

Izzah Shahid; Salma Batool; Maleeha Hassan dkk.

Plant Stress, Vol. 11 · 2024 · Inggris · DOAJ Scopus

The increasing salinization of soils and resulting degradation of irrigated lands have directly affected 2.6 billion hectares of dryland agriculture worldwide. This phenomenon has led to significant qualitative and quantitative losses in crop production. The absorption and accumulation of ions…

Multifactorial Evaluation of Honey from Pakistan: Essential Minerals, Antioxidant Potential, and Toxic Metal Contamination with Relevance to Human Health Risk

Sana; Waqar Ahmad; Farooq Anwar dkk.

Foods, Vol. 14 No. 14 · 2025 · Inggris · DOAJ Scopus

Honey is prized for its nutritional and healing properties, but its quality can be affected by contamination with toxic elements. This study evaluates the nutritional value and health risks of fifteen honey samples from different agro-climatic regions of Pakistan. Physicochemical properties such as…

Kappa-carrageenan and sodium alginate-based pH-responsive hydrogels for controlled release of methotrexate

Muhammad Anees Ur Rehman Qureshi; Nasima Arshad; Atta Rasool dkk.

Royal Society Open Science, Vol. 11 No. 4 · 2024 · Inggris · DOAJ Scopus

Despite remarkable progress in medical sciences, modern man is still fighting the battle against cancer. In 2022, only in the USA, 640 000 deaths and 2 370 000 patients were reported because of cancer. Chemotherapy is the most widely used for cancer treatments. However, chemotherapeutics have…

Bioassays guided isolation of berberine from Berberis lycium and its neuroprotective role in aluminium chloride induced rat model of Alzheimer’s disease combined with insilico molecular docking

Hammad Ismail; Dania Khalid; Durdana Waseem dkk.

PLoS ONE, Vol. 18 No. 11 · 2023 · Inggris · DOAJ Scopus