11 hasil untuk "Johnson O. Oladele"

Editorial: Enhancing cancer therapy: integrating plant-derived bioactives with chemotherapy through traditional knowledge and modern advances

Johnson O. Oladele; Ebenezer I. O. Ajayi; Omowumi O. Adewale dkk.

Frontiers in Pharmacology, Vol. 17 · 2026 · Inggris · DOAJ Scopus

Neuroprotective mechanism of Vernonia amygdalina in a rat model of neurodegenerative diseases

Johnson O. Oladele; Oyedotun M. Oyeleke; Oluwaseun T. Oladele dkk.

Toxicology Reports, Vol. 7 · 2020 · Inggris · DOAJ Scopus

The global upsurge in the prevalence of neurodegenerative diseases in recent years has been associated with increase in toxic chemical exposure and release into the biosystem, having over 46.8 million people suffer dementia worldwide. This study focused on elucidating the neuroprotective mechanism…

Application and efficacy of beidellite clay for the adsorption and detoxification of deoxynivalenol (vomitoxin)

Johnson O. Oladele; Meichen Wang; Kelly J. Rivenbark dkk.

Emerging Contaminants, Vol. 10 No. 4 · 2024 · Inggris · DOAJ Scopus

The incidence of mycotoxin occurrence throughout the entire lifespan of some agricultural products could be due to climatic conditions and environmental factors (including high temperature, drought, and heavy rainfall) that enhance growth of fungi. Deoxynivalenol (DON) which is also referred to as…

Green-Engineered Clays Tightly Adsorb and Detoxify Environmentally Persistent Polychlorinated Biphenyls and Complex Mixtures

Johnson O. Oladele; Xenophon Xenophontos; Phanourios Tamamis dkk.

Toxics, Vol. 14 No. 7 · 2026 · Inggris · DOAJ Scopus

Commonly occurring polychlorinated biphenyls (PCBs) in the environment have been linked to a broad range of adverse toxicological effects in both animals and humans. In this study, in vitro, in silico, and in vivo models were used to investigate the surface interactions of PCBs with…

Chlorophyll-Amended Organoclays for the Detoxification of Ochratoxin A

Johnson O. Oladele; Meichen Wang; Xenophon Xenophontos dkk.

Toxins, Vol. 16 No. 11 · 2024 · Inggris · DOAJ Scopus

Climate change has been associated with outbreaks of mycotoxicosis following periods of drought, enhanced fungal growth, and increased exposure to mycotoxins. For detoxification, the inclusion of clay-based materials in food and drinking water has resulted in a very promising strategy to reduce…

Nitrobenzene-induced hormonal disruption, alteration of steroidogenic pathway, and oxidative damage in rat: protective effects of Vernonia amygdalina

Johnson O. Oladele; Oyedotun M. Oyeleke; Oluwaseun T. Oladele dkk.

Clinical Phytoscience, Vol. 6 No. 1 · 2020 · Inggris · DOAJ

Abstract Background Infertility is a global health burden which affect more than 15% of couples’ population. An impaired hormonal balance, oxidative stress and alteration in the physiological function of the reproductive organ are factors leading to infertility. The present study investigated the…

Green-Engineered Montmorillonite Clays for the Adsorption, Detoxification, and Mitigation of Aflatoxin B1 Toxicity

Johnson O. Oladele; Xenophon Xenophontos; Gustavo M. Elizondo dkk.

Toxins, Vol. 17 No. 3 · 2025 · Inggris · DOAJ Scopus

Dietary and environmental exposure to aflatoxins via contaminated food items can pose major health challenges to both humans and animals. Studies have reported the coexistence of aflatoxins and other environmental toxins. This emphasizes the urgent need for efficient and effective mitigation…

Pre- and post-treatment effects of date fruit phenolics in cisplatin-induced hepatotoxicity

Omowumi O. Adewale; Roseline F. Oyelola; Adeola B. Adenmosun dkk.

Toxicology Reports, Vol. 15 · 2025 · Inggris · DOAJ Scopus

Cisplatin is a popular chemotherapy drug effective in treatment of many solid tumours, however, it is limited by its liver toxicity essentially induced by oxidative stress and inflammation. Meanwhile plant phenolics have a long history of antioxidative and anti-inflammatory capabilities, but…

A systematic review on COVID-19 pandemic with special emphasis on curative potentials of Nigeria based medicinal plants

Johnson O. Oladele; Ebenezer I. Ajayi; Oyedotun M. Oyeleke dkk.

Heliyon, Vol. 6 No. 9 · 2020 · Inggris · DOAJ Scopus

Despite the frightening mortality rate associated with COVID-19, there is no known approved drug to effectively combat the pandemic. COVID-19 clinical manifestations include fever, fatigue, cough, shortness of breath, and other complications. At present, there is no known effective treatment or…

Bioactive composition and protective properties of Talium triangulare in dextran sodium sulphate-induced ulcerative colitis in rats

Oluwaseun T. Oladele; Johnson O. Oladele; Ebenezer I.O. Ajayi dkk.

Pharmacological Research - Modern Chinese Medicine, Vol. 10 · 2024 · Inggris · DOAJ Scopus

Backgrounds: The prevalence of ulcerative colitis (UC) is gradually becoming a global health challenge. Talinum triangulare, commonly called ''waterleaf'' (Tu ren shen in Chinese) is a plant that is cultivated in Asia, western Africa, and other tropical rainforest regions as a food and medicine…

Anti-inflammatory, antioxidant activity, and acetylcholinesterase inhibitory activity of leaf extract of Juglans regia: Insight into the treatment of neurodegenerative diseases

Olukemi R. ADEBAYO; Bosede M. ADEGOKE; Johnson O. OLADELE dkk.

Notulae Scientia Biologicae, Vol. 16 No. 2 · 2024 · Inggris · DOAJ Scopus

Neuroinflammation, depletion of acetylcholine and neuronal oxidative stress are hallmarks of neurodegenerative diseases such as Alzheimer’s disease. This study sought to investigate in vitro acetylcholinesterase inhibitory activity, free radical scavenging, antioxidant activity, and…