16 hasil untuk "Jonathan B. Lin"

Resolution of subretinal fluid in intractable central serous chorioretinopathy with high-dose intravitreal aflibercept

Jonathan B. Lin; Loh-Shan B. Leung

American Journal of Ophthalmology Case Reports, Vol. 37 · 2025 · Inggris · DOAJ Scopus

Purpose: To report an unusual case of a patient with intractable central serous chorioretinopathy with a dramatic treatment response to high-dose intravitreal aflibercept. Methods: Retrospective case report. Results: A 40-year-old female patient presented with decreased vision after use of…

Longitudinal Growth Differentiation Factor 15 (GDF15) and Long-term Intraocular Pressure Fluctuation in Glaucoma: A Pilot Study

Jonathan B. Lin; Arsham Sheybani; Andrea Santeford dkk.

Journal of Ophthalmic & Vision Research, Vol. 16 · 2021 · Inggris · DOAJ Scopus

Purpose: Growth Differentiation Factor 15 (GDF15) was previously identified as a molecular marker of retinal ganglion cell stress in rodent models of glaucoma and was elevated in the aqueous humor (AH) of patients with primary open-angle glaucoma as a possible risk factor for glaucoma progression…

“Complement-ary” Therapies for Age-Related Macular Degeneration

Jonathan B. Lin, MD, PhD; Rajendra S. Apte, MD, PhD

Ophthalmology Science, Vol. 2 No. 2 · 2022 · Inggris · DOAJ Scopus

Preoperative electrophysiological characterization of patients with primary macula-involving rhegmatogenous retinal detachment

Jonathan B Lin; Julia Sein; Gregory P Van Stavern dkk.

Journal of Ophthalmic & Vision Research, Vol. 13 No. 3 · 2018 · Inggris · DOAJ Scopus

Purpose: To determine 1) which components of retinal function are impaired after rhegmatogenous retinal detachment, 2) which outer retinal pathways (rod- or cone-driven) are more severely affected, and 3) whether there is concomitant inner retinal dysfunction. Methods: We conducted a prospective…

LOSS OF FORM VISION IMPAIRS SPATIAL IMAGERY

Valeria eOccelli; Jonathan B. Lin; Simon A Lacey dkk.

Frontiers in Human Neuroscience, Vol. 8 · 2014 · Inggris · DOAJ Scopus

Previous studies have reported inconsistent results when comparing spatial imagery performance in the blind and the sighted, with some, but not all, studies demonstrating deficits in the blind. Here, we investigated the effect of visual status and individual preferences (cognitive style) on…

Trends in immunomodulatory therapy for the treatment of chronic uveitis in the United States

Charles Zhang; Sinan Ersan; Jonathan B. Lin dkk.

Journal of Ophthalmic Inflammation and Infection, Vol. 15 No. 1 · 2025 · Inggris · DOAJ Scopus

Abstract Background Chronic uveitis, a major cause of legal blindness in the United States, often requires long-term immunomodulatory therapy (IMT). This study aims to characterize trends in systemic IMT use among adults with chronic uveitis in United States from 2005 to 2025. Methods This…

Corrigendum: Loss of form vision impairs spatial imagery

Valeria eOccelli; Jonathan B. Lin; Simon eLacey dkk.

Frontiers in Human Neuroscience, Vol. 8 · 2014 · Inggris · DOAJ Scopus

Risk of Glaucoma after Pars Plana Vitrectomy in a Large Federated Health Record Network

Jonathan B. Lin, MD, PhD; Karen M. Wai, MD; Prithvi Mruthyunjaya, MD, MHS dkk.

Ophthalmology Science, Vol. 6 No. 1 · 2026 · Inggris · DOAJ Scopus

Purpose: To examine the risk of glaucoma after pars plana vitrectomy (PPV). Design: We conducted a retrospective cohort study using aggregate electronic health record data from the large, federated TriNetX network. Subjects: We identified a retrospective cohort of 42 242 patients from 67 health…

Neuroprotection for Age-Related Macular Degeneration

Jonathan B. Lin, MD, PhD; Yusuke Murakami, MD, PhD; Joan W. Miller, MD dkk.

Ophthalmology Science, Vol. 2 No. 4 · 2022 · Inggris · DOAJ Scopus

Age-related macular degeneration (AMD) is a leading cause of blindness worldwide. Early to intermediate AMD is characterized by the accumulation of lipid- and protein-rich drusen. Late stages of the disease are characterized by the development of choroidal neovascularization, termed “exudative” or…

Systemic Dyslipidemia in Age-related Macular Degeneration

Brandon Li; Deborah Goss; Joan W. Miller, MD dkk.

Ophthalmology Science, Vol. 4 No. 1 · 2024 · Inggris · DOAJ Scopus

Topic: Though lipid and cholesterol dyshomeostasis is thought to contribute to the pathogenesis of age-related macular degeneration (AMD), there is no consensus regarding which elements of systemic lipid homeostasis are perturbed in AMD. In this systematic review and meta-analysis, an update to…

Systemic Complement Activation Profiles in Nonexudative Age-Related Macular Degeneration

Jonathan B. Lin, MD, PhD; Stylianos Serghiou, MD, PhD; Joan W. Miller, MD dkk.

Ophthalmology Science, Vol. 2 No. 2 · 2022 · Inggris · DOAJ Scopus

Topic: To evaluate whether differences exist in systemic complement activation profiles in patients with early to intermediate nonexudative age-related macular degeneration (AMD) or geographic atrophy (GA) compared with control participants without AMD. Clinical Relevance: Complement inhibition has…

Impact of Prior Diabetic Retinal Screening on Hospitalization and Ophthalmic Follow-Up in Diabetic Patients with Newly Diagnosed Proliferative Diabetic Retinopathy

Charles Zhang; Neel R. Sonik; Zoe J. Tsoukas dkk.

Diagnostics, Vol. 16 No. 10 · 2026 · Inggris · DOAJ Scopus

Background/Objectives: This retrospective cohort study compared hospitalization and follow-up rates in patients with newly diagnosed proliferative diabetic retinopathy (PDR) versus those without prior diabetic retinopathy (DR) screening. Methods: Using TriNetX, a global electronic health record…

Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration

Norimitsu Ban; Tae Jun Lee; Abdoulaye Sene dkk.

Journal of Lipid Research, Vol. 59 No. 8 · 2018 · Inggris · DOAJ Scopus

Photoreceptors have high intrinsic metabolic demand and are exquisitely sensitive to metabolic perturbation. In addition, they shed a large portion of their outer segment lipid membranes in a circadian manner, increasing the metabolic burden on the outer retina associated with the resynthesis of…

Neuroprotective role of retinal SIRT3 against acute photo-stress

Norimitsu Ban; Yoko Ozawa; Hideto Osada dkk.

npj Aging and Mechanisms of Disease, Vol. 3 No. 1 · 2017 · Inggris · DOAJ

Author Summary Sirtuins are nicotinamide adenine dinucleotide-dependent protein deacetylases. Among seven sirtuins, SIRT3 is a key regulator of mitochondrial function. However, functions of SIRT3 in the retina are largely unknown. In this study, we investigated the role of retinal SIRT3 in a mouse…

Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging

Jonathan B. Lin; Abdoulaye Sene; Andrea Santeford dkk.

EBioMedicine, Vol. 32 · 2018 · Inggris · DOAJ Scopus

Macrophage aging is pathogenic in numerous diseases, including age-related macular degeneration (AMD), a leading cause of blindness in older adults. Although prior studies have explored the functional consequences of macrophage aging, less is known about its cellular basis or what defines the…

NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

Jonathan B. Lin; Shunsuke Kubota; Norimitsu Ban dkk.

Cell Reports, Vol. 17 No. 1 · 2016 · Inggris · DOAJ Scopus

Photoreceptor death is the endpoint of many blinding diseases. Identifying unifying pathogenic mechanisms in these diseases may offer global approaches for facilitating photoreceptor survival. We found that rod or cone photoreceptor-specific deletion of nicotinamide phosphoribosyltransferase…