53 hasil untuk "Maria Stepanova"
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Artikel Jurnal Teks lengkap
Comprehensive quality assessment in higher education
The article presents an analysis of approaches towards the development of a system of comprehensive quality assessment of education based on an example of one of Russia's major institutions of higher education. The system encompasses all the participants in the educational process and related…
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Effects of Temperature on the p53-DNA Binding Interactions and Their Dynamical Behavior: Comparing the Wild Type to the R248Q Mutant
Background: The protein p53 plays an active role in the regulation of cell cycle. In about half of human cancers, the protein is inactivated by mutations located primarily in its DNA-binding domain. Interestingly, a number of these mutations possess temperature-induced DNA-binding characteristics…
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Aggregation of Aβ 40/42 chains in the presence of cyclic neuropeptides investigated by molecular dynamics simulations
Alzheimer’s disease is associated with the formation of toxic aggregates of amyloid beta (Aβ) peptides. Despite tremendous efforts, our understanding of the molecular mechanisms of aggregation, as well as cofactors that might influence it, remains incomplete. The small cyclic neuropeptide…
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Soft skills: students and employers crave
Abstract This study focuses on soft skills – over-professional competencies that are assessed on a par with professional competencies in today’s world, including for employment purposes. At ITMO University these skills are taught as a separate block of compulsory subjects for students’ choice. The…
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Molecular Mechanisms in the Activation of Abscisic Acid Receptor PYR1
The pyrabactin resistance 1 (PYR1)/PYR1-like (PYL)/regulatory component of abscisic acid (ABA) response (RCAR) proteins comprise a well characterized family of ABA receptors. Recent investigations have revealed two subsets of these receptors that, in the absence of ABA, either form inactive…
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Surface-enhanced Raman spectroscopy detection of protein-ligand binding using D-glucose and glucose binding protein on nanostructured plasmonic substrates
Conjugated nano-biological architectures interfacing solid nano-structured surfaces with biological polymers have gained significant attention due to their potential biosensing and biocatalytic applications. However, efficient characterization of such integrated systems remains a challenge. We…
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Development and validation of a primary sclerosing cholangitis-specific health-related quality of life instrument: CLDQ-PSC
Objectives:. To understand the full impact of primary sclerosing cholangitis (PSC) on patients’ health, it is important to assess their health-related quality of life (HRQL). Using the Chronic Liver Disease Questionnaire (CLDQ), we aimed to develop and validate a PSC-specific HRQL instrument…
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Molecular mechanisms in the selective basal activation of pyrabactin receptor 1: Comparative analysis of mutants
Pyrabactin receptors (PYR) play a central role in abscisic acid (ABA) signal transduction; they are ABA receptors that inhibit type 2C protein phosphatases (PP2C). Molecular aspects contributing to increased basal activity of PYR against PP2C are studied by molecular dynamics (MD) simulations. An…
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Validation of the Chronic Liver Disease Questionnaire for MASH (CLDQ-MASH)
Background & Aims: The new nomenclature for metabolic dysfunction-associated steatohepatitis (MASH) requires presence of steatohepatitis in the context of at least one cardiometabolic risk. Having a health-related quality of life (HRQL) instrument validated specifically in patients with MASH is…
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Artikel Jurnal Teks lengkap
Safe Meat, Smart Science: Biotechnology’s Role in Antibiotic Residue Removal
The widespread use of antibiotics in livestock farming has led to the persistent issue of antibiotic residues in meat products, raising significant concerns for food safety and public health. These residues can contribute to the emergence and spread of antimicrobial resistance (AMR), a growing…
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Artikel Jurnal Teks lengkap
Knowledge-Based Identification of Soluble Biomarkers: Hepatic Fibrosis in NAFLD as an Example
The discovery of biomarkers is often performed using high-throughput proteomics-based platforms and is limited to the molecules recognized by a given set of purified and validated antigens or antibodies. Knowledge-based, or systems biology, approaches that involve the analysis of integrated data…
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Statin use is not associated with liver related mortality
Background and Aim. Statins are commonly used medications for the treatment of dyslipidemia. Although there are reported cases of hepatotoxicity related to statins, very few are associated with severe course and liver failure.Material and methods. We used the Third National Health and Nutrition…
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Predictors of chronic liver disease in individuals with human immunodeficiency virus infection
Introduction. Chronic liver disease (CLD) is becoming a major cause of mortality in patients who are positive with human immunodeficiency virus (HIV). Our aim was to assess the prevalence of CLD in HIV+ individuals.Material and methods. We utilized the National Health and Nutrition Examination…
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Photoluminescence emission in arsenic sulfide nanocomposite
Synthesis and characterization of the optical properties of materials especially at a nanoscale, is considered as important tasks for the engineering of photonic devices and systems. In this paper we study the photoluminescence of new nanocomposite material consisting of arsenic sulfide doped in…
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Assessments of Health Utilities in Patients With Metabolic Dysfunction-Associated Steatohepatitis: Cross-Walk Between Disease-Specific Chronic Liver Disease Questionnaire, Short Form SF-6D, and EuroQol EQ-5D Instruments
Background and Aims: The EuroQol-5D (EQ-5D) is a commonly used measure of health utilities to calculate quality-adjusted life years. For the clinical trials that use Chronic Liver Disease Questionnaire-nonalcoholic fatty liver disease (CLDQ-NAFLD) or Short Form-36 (SF-36), ability to convert the…