8 hasil untuk "Pascal Devant"

Protocol to purify recombinant inflammatory caspases and assess their catalytic activity in vitro

Pascal Devant; Jonathan C. Kagan

STAR Protocols, Vol. 3 No. 4 · 2022 · Inggris · DOAJ Scopus

…details on the use and execution of this protocol, please refer to Devant et al. (2021).1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Molecular mechanisms of gasdermin D pore-forming activity

Pascal Devant; Jonathan C. Kagan

Nature Immunology · 2023 · Inggris · OpenAlex Scopus

Gasdermin D pore-forming activity is redox-sensitive

Pascal Devant; Elvira Boršić; Elsy M. Ngwa dkk.

Cell Reports, Vol. 42 No. 1 · 2023 · Inggris · DOAJ Scopus

Summary: Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune signaling organelles that induce pyroptosis. The mechanisms by which ROS control inflammasome activities are unclear and may be multifaceted. Herein, we report that the protein gasdermin D…

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Charles Lee Evavold; Iva Hafner‐Bratkovič; Pascal Devant dkk.

Cell · 2021 · Inggris · OpenAlex Scopus

Engineering an Antibody V Gene-Selective Vaccine

Larance Ronsard; Ashraf S. Yousif; Julianne Peabody dkk.

Frontiers in Immunology, Vol. 12 · 2021 · Inggris · DOAJ Scopus

The ligand-binding surface of the B cell receptor (BCR) is formed by encoded and non-encoded antigen complementarity determining regions (CDRs). Genetically reproducible or ‘public’ antibodies can arise when the encoded CDRs play deterministic roles in antigen recognition, notably within human…

Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

Samoil Sekulovski; Pascal Devant; Silvia Panizza dkk.

Nature Communications, Vol. 12 No. 1 · 2021 · Inggris · DOAJ Scopus

Mutations within subunits of the tRNA splicing endonuclease complex (TSEN) are associated with pontocerebellar hypoplasia (PCH). Here the authors show that tRNA intron excision is catalyzed by tetrameric TSEN assembled from inactive heterodimers, and provide evidence that modulation of TSEN…

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

Jazlyn P Borges; Ragnhild SR Sætra; Allen Volchuk dkk.

eLife, Vol. 11 · 2022 · Inggris · DOAJ

First recognized more than 30 years ago, glycine protects cells against rupture from diverse types of injury. This robust and widely observed effect has been speculated to target a late downstream process common to multiple modes of tissue injury. The molecular target of glycine that mediates…

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D

Gang Du; Liam B. Healy; Liron David dkk.

Nature · 2024 · Inggris · OpenAlex Scopus