16 results for "Pascal Leblanc"

Viruses in neurodegenerative diseases: More than just suspects in crimes.

Pascal Leblanc; Ina Maja Vorberg

PLoS Pathogens, Vol. 18 No. 8 · 2022 · English · DOAJ Scopus

Neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain…

Also available at: DOAJ, PLOS

Trois années d’inventaire des Coléoptères (Coleoptera) de la Réserve naturelle nationale de la tourbière de Machais (France, Grand Est, Vosges)

Benoît Dodelin; Mathurin Carnet-Viscard; Antoine Cochard et al.

Bulletin de la Société d'Histoire Naturelle et d'Ethnographie de Colmar, Vol. 82 No. 18 · 2025 · French · DOAJ

Trois années d’inventaires des coléoptères dans la Réserve naturelle nationale de la tourbière de Machais (La Bresse) ont permis d’analyser 7 031 spécimens, dont 6 716 ont été identifiés au niveau spécifique pour une diversité de 308 espèces. Au moins six espèces correspondent vraisemblablement à…

Co-Infection with the Friend Retrovirus and Mouse Scrapie Does Not Alter Prion Disease Pathogenesis in Susceptible Mice

Pascal Leblanc; Kim Hasenkrug; Anne Ward et al.

PLoS ONE, Vol. 7 No. 1 · 2012 · English · PLOS Scopus

Prion diseases are fatal, transmissible neurodegenerative diseases of the central nervous system. An abnormally protease-resistant and insoluble form (PrPSc) of the normally soluble protease-sensitive host prion protein (PrPC) is the major component of the infectious prion. During the course of…

Also available at: DOAJ

Spatial Transcriptomics Reveals Signatures of Histopathological Changes in Muscular Sarcoidosis

Hippolyte Lequain; Cyril Dégletagne; Nathalie Streichenberger et al.

Cells, Vol. 12 No. 23 · 2023 · English · DOAJ Scopus

Sarcoidosis is a multisystemic disease characterized by non-caseating granuloma infiltrating various organs. The form with symptomatic muscular involvement is called muscular sarcoidosis. The impact of immune cells composing the granuloma on the skeletal muscle is misunderstood. Here, we…

Correction: Co-Infection with the Friend Retrovirus and Mouse Scrapie Does Not Alter Prion Disease Pathogenesis in Susceptible Mice

Pascal Leblanc; Kim Hasenkrug; Anne Ward et al.

PLoS ONE, Vol. 7 No. 6 · 2012 · English · PLOS Scopus

Also available at: DOAJ

Isotopic Evidence for Disrupted Copper Metabolism in Amyotrophic Lateral Sclerosis

Lucie Sauzéat; Emilien Bernard; Armand Perret-Liaudet et al.

iScience, Vol. 6 · 2018 · English · DOAJ Scopus

Summary: Redox-active metals are thought to be implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). To address this point, we measured the concentrations of 12 elements and, for the first time, the stable isotope compositions of copper (redox-active) and zinc…

Hydroxypropyl-β-Cyclodextrin Depletes Membrane Cholesterol and Inhibits SARS-CoV-2 Entry into HEK293T-ACEhi Cells

Silvia Alboni; Valentina Secco; Bianca Papotti et al.

Pathogens, Vol. 12 No. 5 · 2023 · English · DOAJ Scopus

Vaccination has drastically decreased mortality due to coronavirus disease 19 (COVID-19), but not the rate of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Alternative strategies such as inhibition of virus entry by interference with angiotensin-I-converting enzyme 2 (ACE2)…

Pharmacological inhibition of HDAC6 improves muscle phenotypes in dystrophin-deficient mice by downregulating TGF-β via Smad3 acetylation

Alexis Osseni; Aymeric Ravel-Chapuis; Edwige Belotti et al.

Nature Communications, Vol. 13 No. 1 · 2022 · English · DOAJ Scopus

Here, authors show that Smad3 acetylation via HDAC6 inhibition reverses Duchenne muscular dystrophy-like symptoms in the mdx mouse model, suggesting a potential therapeutic target for the disorder.

Coupling between Myogenesis and Angiogenesis during Skeletal Muscle Regeneration Is Stimulated by Restorative Macrophages

Claire Latroche; Michèle Weiss-Gayet; Laurent Muller et al.

Stem Cell Reports, Vol. 9 No. 6 · 2017 · English · DOAJ Scopus

Summary: In skeletal muscle, new functions for vessels have recently emerged beyond oxygen and nutrient supply, through the interactions that vascular cells establish with muscle stem cells. Here, we demonstrate in human and mouse that endothelial cells (ECs) and myogenic progenitor cells (MPCs)…

H syndrome mimicking Erdheim Chester disease: new entity and therapeutic perspectives

Hippolyte Lequain; Mathieu Gerfaud-Valentin; Jean-François Emile et al.

Haematologica, Vol. 108 No. 8 · 2023 · English · DOAJ Scopus

Sphingolipids in Extracellular Vesicles Released From the Skeletal Muscle Plasma Membrane Control Muscle Stem Cell Fate During Muscle Regeneration

Rhyma Hakkar; Caroline E. Brun; Pascal Leblanc et al.

Journal of Extracellular Vesicles, Vol. 14 No. 9 · 2025 · English · DOAJ Scopus

ABSTRACT Extracellular vesicles (EVs) represent a cytokine‐independent pathway though which skeletal muscle (SkM) cells influence the fate of neighbouring cells, thereby regulating SkM metabolic homeostasis and regeneration. Although SkM‐EVs are increasingly being explored as a therapeutic strategy…

Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles

Laura Le Gall; William J. Duddy; Cecile Martinat et al.

Journal of Cachexia, Sarcopenia and Muscle, Vol. 13 No. 2 · 2022 · English · DOAJ Scopus

Abstract Background The cause of the motor neuron (MN) death that drives terminal pathology in amyotrophic lateral sclerosis (ALS) remains unknown, and it is thought that the cellular environment of the MN may play a key role in MN survival. Several lines of evidence implicate vesicles in ALS…