6 hasil untuk "Patrick Devlin"
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Artikel Jurnal
Genotype-expression interactions for BDNF across human brain regions
Abstract Background Genetic variations in brain-derived neurotrophic factor (BDNF) are associated with various psychiatric disorders including depression, obsessive-compulsive disorder, substance use disorders, and schizophrenia; altered gene expression triggered by these genetic variants may serve…
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Artikel Jurnal
The emerging importance of skull-brain interactions in traumatic brain injury
The recent identification of skull bone marrow as a reactive hematopoietic niche that can contribute to and direct leukocyte trafficking into the meninges and brain has transformed our view of this bone structure from a solid, protective casing to a living, dynamic tissue poised to modulate brain…
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Artikel Jurnal
Models and mechanisms of post-stroke dementia and cognitive impairment
Stroke is a leading cause of death and disability globally, with significant long-term impacts such as post-stroke cognitive impairment (PSCI). PSCI affects up to one-third of stroke survivors, substantially increasing their risk of dementia, especially after recurrent strokes. Despite advances in…
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Artikel Jurnal
340 Neuropathological hallmarks during the chronic phase of ischemic stroke in mice and humans
Objectives/Goals: Improvements in acute stroke treatment, including critical care management, have increased survival rates post-stroke. However, many stroke survivors have significant neurological deficits, and stroke remains a leading cause of long-term disability. We aim to study the chronic…
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Artikel Jurnal
Demographic, clinical, and social data predictive of 1-month mortality post-aneurysmal subarachnoid hemorrhage
Introduction: Attempts to develop a multidimensional predictive model for outcomes after aneurysmal subarachnoid hemorrhage have largely failed. Other demographic, clinical, and social information may enhance the predictive value of clinical scales for the prognostication of outcomes. This study…
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Artikel Jurnal
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice
Human mutations in the dystroglycan complex (DGC) result in not only muscular dystrophy but also cognitive impairments. However, the molecular architecture critical for the synaptic organization of the DGC in neurons remains elusive. Here, we report Inhibitory Synaptic protein 1 (InSyn1) is a…