15 hasil untuk "Poonam, Mathur"
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Artikel Jurnal
The influence of inflammation on cardiovascular disease in women
The onset of cardiovascular disease in women is almost a decade later than men, partly due to the protective effect of estrogen prior to menopause. Recently, it was noted that while there have been advances in improving the morbidity and mortality from CVD in women older than 55 years, the…
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Immunomodulatory therapies for COVID-19
PurposeAs COVID-19 disease progresses, the host inflammatory response contributes to hypoxemia and severe and critical illness. In these latter stages of disease, patients may benefit from immunomodulatory therapies to control the aberrant host inflammatory response. In this review, we provide an…
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To Study the Effectiveness of Using Suture Passer in Sacrospinous Vault Fixation Surgery
Background: Pelvic organ prolapse (POP) is a prevalent condition characterized by the descent of pelvic organs due to the weakening of connective tissue and muscles. Sacrospinous ligament fixation (SSLF) is an established surgical technique for managing apical prolapse. This study evaluates the…
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A Prospective Cohort Study on Serum Glycosylated Fibronectin as a Biomarker for Early Prediction of Preeclampsia
Background: Preeclampsia (PE) is a significant hypertensive disorder of pregnancy contributing to maternal and neonatal morbidity and mortality. Early detection and intervention are crucial to reducing the burden of this disease. Glycosylated fibronectin (GlyFn) has emerged as a potential biomarker…
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Artikel Jurnal Teks lengkap
Hepatitis C Virus Infection in Persons Who Inject Drugs in the Middle East and North Africa: Intervention Strategies
There is a high incidence and prevalence of hepatitis C viral infection in persons with or without substance use disorders (SUDs) in the Middle East and North Africa (MENA) region, but only a small number receive comprehensive care. Highly effective direct-acting antiviral (DAA) medications are…
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Artikel Jurnal Teks lengkap
Chronic Hepatitis D Virus Infection and Its Treatment: A Narrative Review
More than 12 million individuals worldwide are chronically infected with the hepatitis D virus (HDV). HDV infection is the most severe form of viral hepatitis since it requires hepatitis B virus co-infection and accelerates progression to cirrhosis and hepatocellular carcinoma. Therefore, treatment…
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Artikel Jurnal
The Impact of Neocolonialism on India’s COVID-19 Response
In this paper, we analyze the impact of COVID-19 in India and the nation’s shortcomings in responding appropriately to the pandemic. We discuss how international vaccine inequities, rooted in neocolonialism, and the WHO’s broad recommendation of Global North pandemic responses (i.e., lockdowns…
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Hot and Cold HCC: Uncoupling Viral Oncogenesis and Therapy
Hepatocellular carcinoma (HCC) is rising in incidence globally. It is the sixth most common cancer and the third leading cause of cancer-related mortality worldwide. Infection with hepatitis B and/or C virus is a significant risk factor for developing HCC. These viruses exert their carcinogenicity…
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Giant Primary Retroperitoneal Teratoma in an Adult: A Case Report
Teratomas are bizarre neoplasms derived from embryonic tissues that are typically found only in the gonadal and sacrococcygeal regions of adults. Retroperitoneal teratomas are rare and present challenging management options. We report here the case of a histologically unusual retroperitoneal tumor…
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Host Immune Response in Chronic Hepatitis Delta: Implications for Pathogenesis and Therapy
Chronic hepatitis delta (CHD) represents the most severe form of viral hepatitis due to rapid disease progression towards liver cancer, leading to high morbidity and mortality. Hepatitis delta virus (HDV) can only infect individuals who are infected with hepatitis B. So far, there is no cure or…
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Repurposing Non-Infectious Therapeutic Agents to Aid in the Treatment of Chronic Biofilm Infections
Antibiotics primarily exert their effect on planktonic microbial states, limiting their ability to eradicate biofilms commonly seen in chronic infections. This is because the minimal inhibitory concentration of antibiotics needed to kill microbes in biofilms can be up to 1000 times greater than…
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Artikel Jurnal
CD38: an ecto-enzyme with functional diversity in T cells
CD38, a nicotinamide adenine dinucleotide (NAD)+ glycohydrolase, is considered an activation marker of T lymphocytes in humans that is highly expressed during certain chronic viral infections. T cells constitute a heterogeneous population; however, the expression and function of CD38 has been…
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Implementation of Updated Febrile Neutropenia Guidelines Decreased Antibiotic Utilization in a Comprehensive Cancer Center
Background: Empiric antibiotic therapy choices and de-escalation practices for the management of febrile neutropenia (FN) can vary. Facility-specific antimicrobial guidelines have an important role in influencing prescription practices for FN and is a foundation of antimicrobial stewardship…
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Artikel Jurnal Teks lengkap
Effects of adolescent fluoxetine treatment on fear-, anxiety- or stress-related behaviors in C57BL/6J or BALB/cJ mice
RATIONALE: 5-Hydroxytryptamine (5-HT, serotonin) plays a major role in brain ontogeny. Disruption of 5-HT during early postnatal development produces lasting changes in rodent ‘emotion-related’ behaviors. Adverse effects of treatment with serotonin reuptake inhibitor (SRI) antidepressants have been…
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Artikel Jurnal
Pharmacological profiling of intravenous MP-04: sustained NAD+ augmentation, immune modulation, and renal protection in preclinical models
IntroductionSystemic inflammation and mitochondrial bioenergetic failure are central drivers of multi-organ dysfunction in advanced liver disease, sepsis, and acute kidney injury (AKI). Currently available therapies remain largely supportive and fail to directly address intracellular NAD+ depletion…