25 hasil untuk "Ruma Banerjee"

Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation.

Nitish Agrawal; Ruma Banerjee

PLoS ONE, Vol. 3 No. 12 · 2008 · Inggris · DOAJ Scopus

Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia. A yeast two-hybrid approach to screen for…

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Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay

Roshan Kumar; Ruma Banerjee

Gut Microbes, Vol. 18 No. 1 · 2026 · Inggris · DOAJ Scopus

Teeming with microbes, the unique biogeography of the gut is shaped by interactions between diet, host and microbial metabolism. Hydrogen sulfide represents one such plane of interaction in the lower gut where it is largely the product of microbial activity. Sulfide oxidation by host epithelial…

Cyclic Voltammetry of Human Dimeric Cystathionine

Sebastián Carballal, Fernando Zinola, Ruma Banerjee and Beatriz Alvarez

International Journal of Electrochemical Science, Vol. 3 No. 1 · 2008 · Inggris · DOAJ Scopus

Cystathionine b-synthase (CBS) catalyzes the pyridoxal phosphate-dependent condensation of serine and homocysteine into cystathionine and participates in the transsulfuration pathway which converts methionine into cysteine. CBS is unique in having a heme cofactor of unknown function with axial…

Comparative Genomics of Cell Envelope Components in Mycobacteria

Ruma Banerjee; Pankaj Vats; Sonal Dahale dkk.

PLoS ONE, Vol. 6 No. 5 · 2011 · Inggris · PLOS Scopus

Mycobacterial cell envelope components have been a major focus of research due to their unique features that confer intrinsic resistance to antibiotics and chemicals apart from serving as a low-permeability barrier. The complex lipids secreted by Mycobacteria are known to evoke/repress host-immune…

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Nitrite Reductase Activity and Inhibition of H 2 S Biogenesis by Human Cystathionine ß-Synthase

Carmen Gherasim; Pramod K. Yadav; Omer Kabil dkk.

PLoS ONE, Vol. 9 No. 1 · 2014 · Inggris · PLOS Scopus

Nitrite was recognized as a potent vasodilator >130 years and has more recently emerged as an endogenous signaling molecule and modulator of gene expression. Understanding the molecular mechanisms that regulate nitrite metabolism is essential for its use as a potential diagnostic marker as well as…

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Genetic diversity of ‘Very Important Pharmacogenes’ in two South-Asian populations

Neeraj Bharti; Ruma Banerjee; Archana Achalere dkk.

PeerJ, Vol. 9 · 2021 · Inggris · DOAJ Scopus

Objectives Reliable identification of population-specific variants is important for building the single nucleotide polymorphism (SNP) profile. In this study, genomic variation using allele frequency differences of pharmacologically important genes for Gujarati Indians in Houston (GIH) and Indian…

Estimation of genetic variation in vitiligo associated genes: Population genomics perspective

Neeraj Bharti; Ruma Banerjee; Archana Achalare dkk.

BMC Genomic Data, Vol. 25 No. 1 · 2024 · Inggris · DOAJ Scopus

Abstract Background Vitiligo is an auto-immune progressive depigmentation disorder of the skin due to loss of melanocytes. Genetic risk is one of the important factors for development of vitiligo. Preponderance of vitiligo in certain ethnicities is known which can be analysed by understanding the…

Understanding the Genetic Diversity of Mycobacterium africanum Using Phylogenetics and Population Genomics Approaches

Muthukumar Balamurugan; Ruma Banerjee; Sunitha Manjari Kasibhatla dkk.

Frontiers in Genetics, Vol. 13 · 2022 · Inggris · DOAJ Scopus

A total of two lineages of Mycobacterium tuberculosis var. africanum (Maf), L5 and L6, which are members of the Mycobacterium tuberculosis complex (MTBC), are responsible for causing tuberculosis in West Africa. Regions of difference (RDs) are usually used for delineation of MTBC. With increased…

Cross-cohort meta-analysis of respiratory microbiota predicts metabolic adaptations of microbes in pulmonary tuberculosis

Sucheta Patil; Ruma Banerjee; Sunitha M. Kasibhatla dkk.

Medicine in Microecology, Vol. 29 · 2026 · Inggris · DOAJ Scopus

Background: Understanding the microbial species and their metabolic pathways associated with pulmonary tuberculosis (PTB) has significant potential to improve current treatments through the identification of novel biomarkers and therapeutic targets. Recent metagenomic studies have enhanced our…

Swavlamban Health Insurance scheme for persons with disabilities: An experiential account

Joseph Wilson James; Chethan Basavarajappa; Thanapal Sivakumar dkk.

Indian Journal of Psychiatry, Vol. 61 No. 4 · 2019 · Inggris · DOAJ Scopus

Context: Out-of-pocket expenditure on health in India is high. Many people including persons with disability (PwD) face catastrophic health expenditure. Health insurance is a promising strategy to overcome this burden. Swavlamban was the first health insurance for PwD which also covered mental…

Architecture of the human G-protein-methylmalonyl-CoA mutase nanoassembly for B12 delivery and repair

Romila Mascarenhas; Markus Ruetz; Harsha Gouda dkk.

Nature Communications, Vol. 14 No. 1 · 2023 · Inggris · DOAJ Scopus

Abstract G-proteins function as molecular switches to power cofactor translocation and confer fidelity in metal trafficking. The G-protein, MMAA, together with MMAB, an adenosyltransferase, orchestrate cofactor delivery and repair of B12-dependent human methylmalonyl-CoA mutase (MMUT). The…

Heme-Thiolate Perturbation in Cystathionine β‑Synthase by Mercury Compounds

Dayana Benchoam; Ernesto Cuevasanta; Laia Julió Plana dkk.

ACS Omega, Vol. 6 No. 3 · 2021 · Inggris · DOAJ Scopus

Time line of redox events in aging postmitotic cells

Nicolas Brandes; Heather Tienson; Antje Lindemann dkk.

eLife, Vol. 2 · 2013 · Inggris · DOAJ

The precise roles that oxidants play in lifespan and aging are still unknown. Here, we report the discovery that chronologically aging yeast cells undergo a sudden redox collapse, which affects over 80% of identified thiol-containing proteins. We present evidence that this redox collapse is not…

An Allosteric Mechanism for Switching between Parallel Tracks in Mammalian Sulfur Metabolism

Tatyana K. Korendyaseva; Denis N. Kuvatov; Vladimir A. Volkov dkk.

PLoS Computational Biology, Vol. 4 No. 5 · 2008 · Inggris · PLOS Scopus

Methionine (Met) is an essential amino acid that is needed for the synthesis of S-adenosylmethionine (AdoMet), the major biological methylating agent. Methionine used for AdoMet synthesis can be replenished via remethylation of homocysteine. Alternatively, homocysteine can be converted to cysteine…

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Barriers in Accessing Social Welfare Benefits for Families of Children With Intellectual and Developmental Disorders in Rural Karnataka: A Situation Analysis

Shanivaram K. Reddy; Aarti Jagnnathan; Guddekoppa H. Ashraf dkk.

Indian Journal of Psychological Medicine, Vol. 43 · 2021 · Inggris · DOAJ Scopus

Background: Several government schemes exist for the welfare of families having children with intellectual and developmental disorders (IDDs) in India. However, these schemes are often not utilized. An understanding of the barriers to access these social welfare benefits, especially in rural areas…

Genomic characterization of multidrug-resistant Klebsiella pneumoniae clinical isolates from India

Deepali Desai; Tina Sharma; Nageswari Gandham dkk.

Scientific Reports, Vol. 16 No. 1 · 2026 · Inggris · DOAJ Scopus

Abstract Klebsiella pneumoniae is an emerging global threat driven by rising antimicrobial resistance and the spread of hypervirulent lineages. To investigate its evolving genomic landscape in India, we characterized two clinical K. pneumoniae isolates, NG_299 and NG_300, obtained from a tertiary…