16 hasil untuk "Shu-Fu Lin"
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Artikel Jurnal
Outcomes of Patients With Metastatic Differentiated Thyroid Cancer After Excellent Response to Treatment
BackgroundTo evaluate the outcomes in differentiated thyroid cancer (DTC) patients who achieved excellent response to initial treatment and developed distant metastasis during follow-up.MethodsThyroid cancer patients registered in Chang Gung Memorial Hospital thyroid cancer database between January…
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Artikel Jurnal
Risk Factors and Prognosis for Metastatic Follicular Thyroid Cancer
BackgroundFollicular thyroid cancer (FTC) is the second most common malignancy of thyroid. About 7%–23% of patients with FTC have distant metastasis. The aim of this study was to investigate the risk factors associated with distant metastasis and the impact of distant metastasis on survival in FTC…
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Artikel Jurnal Teks lengkap
A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer
Background: We explored the therapeutic effects of dinaciclib, a cyclin-dependent kinase (CDK) inhibitor, in the treatment of thyroid cancer. Materials and methods: Seven cell lines originating from three pathologic types of thyroid cancer (papillary, follicular and anaplastic) were studied. The…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Utility of a Histone Deacetylase Inhibitor (PXD101) for Thyroid Cancer Treatment
Background: We evaluated the therapeutic effects of the histone deacetylase inhibitor PXD101 alone and in combination with conventional chemotherapy in treating thyroid cancer. Methodology/Principal Findings: We studied eight cell lines from four types of thyroid cancer (papillary, follicular…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Utility of a PI3K/mTOR Inhibitor (NVP-BEZ235) for Thyroid Cancer Therapy
Background: We assessed the utility of the dual PI3K/mTOR inhibitor NVP-BEZ235 (BEZ235) as single agent therapy and in combination with conventional chemotherapy for thyroid cancer. Methodology/Principal Findings: Eight cell lines from four types of thyroid cancer (papillary, follicular…
Juga tersedia di: DOAJ
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Artikel Jurnal Teks lengkap
Long-term follow-up of papillary and follicular thyroid carcinomas with bone metastasis
The aims of this study were to investigate papillary and follicular thyroid carcinomas with bone metastasis in various clinical presentations and to determine the prognostic factors after multimodality treatment. A retrospective analysis was performed of 3,120 patients with papillary and follicular…
Juga tersedia di: DOAJ
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Artikel Jurnal
Prognosis of Multifocal Papillary Thyroid Carcinoma
This study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed…
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Artikel Jurnal
Alterations of Gut Microbiota in Patients With Graves’ Disease
Graves’ disease (GD) is a systemic autoimmune disease characterized by hyperthyroidism. Evidence suggests that alterations to the gut microbiota may be involved in the development of autoimmune disorders. The aim of this study was to characterize the composition of gut microbiota in GD patients…
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Artikel Jurnal
Association of pregnancy outcomes in women with type 2 diabetes treated with metformin versus insulin when becoming pregnant
Abstract Background Metformin use in pregnancy is controversial because metformin crosses the placenta and the safety on the fetus has not been well-established. This retrospective study aimed to compare pregnancy outcomes in women with preexisting type 2 diabetes receiving metformin or standard…
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Artikel Jurnal
Synergistic effects of the combination of trametinib and alpelisib in anaplastic thyroid cancer with BRAF and PI3KCA co-mutations
Background: Anaplastic thyroid cancer (ATC), a rare and aggressive malignancy with a poor prognosis, has shown promise with the approved dabrafenib/trametinib combination for BRAFV600E mutation. Co-occurring PI3KCA mutations, identified as negative prognostic factors in lung cancer with BRAFV600E…
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Artikel Jurnal
Evaluation of recurrence risk in patients with papillary thyroid cancer through tumor-node-metastasis staging: A single-center observational study in Taiwan
Background: Many patients with papillary thyroid cancer (PTC) demonstrate satisfactory outcomes. However, 8%–28% of patients with PTC show tumor recurrence, which may affect prognosis. Therefore, identifying factors associated with tumor recurrence in patients with PTC may be helpful to refine…
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Artikel Jurnal
Genomic landscape and comparative analysis of tissue and liquid-based NGS in Taiwanese anaplastic thyroid carcinoma
Abstract Anaplastic thyroid carcinoma (ATC) is an aggressive cancer that requirements rapid diagnosis and multimodal treatment. Next-generation sequencing (NGS) aids in personalized therapies and improved trial enrollment. The role of liquid-based NGS in ATC remains unclear. This study analyzed ATC…