98 hasil untuk "Torsten Zuberbier"

Classification of urticaria

Torsten Zuberbier

Indian Journal of Dermatology, Vol. 58 No. 3 · 2013 · Inggris · DOAJ Scopus

Classification is based on GA 2 LEN/EAACI/WAO/EDF guidelines (2009). These guidelines classify urticaria according to clinical manifestations. Urticaria is mediated by mast cells. According to level of mast cell degranulation clinical signs are superficial (Urticaria) or deep swelling (Angioedema).

A Summary of the New International EAACI/GA2LEN/EDF/WAO Guidelines in Urticaria

Torsten Zuberbier, MD

World Allergy Organization Journal, Vol. 5 · 2012 · Inggris · DOAJ Scopus

Urticaria is a heterogeneous group of disorders, especially acute urticaria and angiooedema can be a medical emergency. This paper summarizes the EAACI/GA2LEN/EDF/WAO guidelines, the most recent international guidelines from 2009. Patients with urticaria are often not diagnosed and treated…

The safety and tolerability profile of bilastine for chronic urticaria in children

Nikolaos G. Papadopoulos; Torsten Zuberbier

Clinical and Translational Allergy, Vol. 9 No. 1 · 2019 · Inggris · DOAJ Scopus

Abstract Background Urticaria is a condition defined by the development of wheals, angioedema or both. It is classified based on its duration as acute (≤ 6 weeks) or chronic (> 6 weeks). Chronic urticaria is less frequent than acute one in children, but it represents a debilitating condition…

The membrane matters: Plasma membrane composition shapes MRGPRX2-driven immune responses

Liron Lerner; Magda Babina; Torsten Zuberbier dkk.

Exploration of Asthma & Allergy, Vol. 4 · 2026 · Inggris · DOAJ

The composition and biophysical characteristics of the plasma membrane are pivotal in regulating mast cell immune functions by influencing receptor distribution, activation, and intracellular signaling pathways. This article highlights the impact of plasma membrane components, such as cholesterol…

Thymic Stromal Lymphopoietin Promotes MRGPRX2-Triggered Degranulation of Skin Mast Cells in a STAT5-Dependent Manner with Further Support from JNK

Magda Babina; Zhao Wang; Kristin Franke dkk.

Cells, Vol. 10 No. 1 · 2021 · Inggris · DOAJ Scopus

Thymic stromal lymphopoietin (TSLP) is released by epithelial cells following disturbed homeostasis to act as “alarmin” and driver of Th2-immunity. Aberrant TSLP expression is a hallmark of atopic diseases, including atopic dermatitis (AD). Mast cells (MCs) are overabundant in AD lesions and show…

Beyond Allergies—Updates on The Role of Mas-Related G-Protein-Coupled Receptor X2 in Chronic Urticaria and Atopic Dermatitis

Liron Lerner; Magda Babina; Torsten Zuberbier dkk.

Cells, Vol. 13 No. 3 · 2024 · Inggris · DOAJ Scopus

Mast cells (MCs) are an important part of the immune system, responding both to pathogens and toxins, but they also play an important role in allergic diseases, where recent data show that non-IgE-mediated activation is also of relevance, especially in chronic urticaria (CU) and atopic dermatitis…

Icatibant Acts as a Balanced Ligand of MRGPRX2 in Human Skin Mast Cells

Zhuoran Li; Jean Schneikert; Gürkan Bal dkk.

Biomolecules, Vol. 15 No. 9 · 2025 · Inggris · DOAJ Scopus

MRGPRX2 (Mas-related G protein-coupled receptor member X2) is implicated in mast cell (MC)-driven disorders due to its ability to bind diverse ligands, which may be G-protein-biased or balanced, with the latter activating both G-proteins and the β-arrestin pathway. Icatibant, a peptide drug…

A Novel Cell Culture System to Improve MRGPRX2 Research in Human Skin Mast Cells

Zhuoran Li; Jean Schneikert; Anja Wegner dkk.

Clinical and Translational Allergy, Vol. 15 No. 10 · 2025 · Inggris · DOAJ Scopus

ABSTRACT Background MRGPRX2, a receptor central to mast cell (MC) activation and related skin diseases, is selectively expressed in skin MCs but downregulated during culture by stem cell factor (SCF) and interleukin‐4 (IL‐4). Objective To identify culture conditions that preserve MC viability while…

Differential Responsiveness of Human Skin Mast Cells to SCF and IL-33: Reduced Reactivity to SCF but Not to IL-33 in the Post-Mitotic Phase

Manqiu Jin; Jean Schneikert; Anja Wegner dkk.

Cells, Vol. 15 No. 5 · 2026 · Inggris · DOAJ Scopus

Skin mast cells (MCs) play a vital role in acute allergic reactions and also contribute to chronic dermatoses partially through cytokine production. Key growth factors (GFs), such as SCF and IL-33, orchestrate MC survival and activity. Whether early responses differ between these factors remains…

Synergism between IL-33 and MRGPRX2/FcεRI Is Primarily Due to the Complementation of Signaling Modules, and Only Modestly Supplemented by Prolonged Activation of Selected Kinases

Kristin Franke; Zhuoran Li; Gürkan Bal dkk.

Cells, Vol. 12 No. 23 · 2023 · Inggris · DOAJ Scopus

Skin mast cells (MCs) express high levels of MRGPRX2, FcεRI, and ST2, and vigorously respond to their ligands when triggered individually. IL-33/ST2 also potently synergizes with other receptors, but the molecular underpinnings are poorly understood. Human skin-derived MCs were stimulated via…

Evaluating the Impact of Laundry Detergents on the Skin Microbiome of Atopic Dermatitis Patients—A Clinical Study

Demetrios Christou; Katarina Stevanovic; Stefan Evers dkk.

Health Science Reports, Vol. 7 No. 12 · 2024 · Inggris · DOAJ Scopus

ABSTRACT Background and Aims Remnants of laundry detergent ingredients are suspected to be in constant contact with the skin. Allergy sufferers need assurance that the chemicals in everyday products do not cause such disruption. The purpose of this study was to evaluate the effects and tolerability…

Clorfl86/RHEX Is a Negative Regulator of SCF/KIT Signaling in Human Skin Mast Cells

Kristin Franke; Gürkan Bal; Zhuoran Li dkk.

Cells, Vol. 12 No. 9 · 2023 · Inggris · DOAJ Scopus

Mast cells (MCs) are key effector cells in allergic and inflammatory diseases, and the SCF/KIT axis regulates most aspects of the cells’ biology. Using terminally differentiated skin MCs, we recently reported on proteome-wide phosphorylation changes initiated by KIT dimerization. C1orf186/RHEX was…

Long-term evaluation of omalizumab therapy in patients with severe allergic asthma

Karl-Christian Bergmann; Teresa Hartung; Sebastian Kugler dkk.

Exploration of Asthma & Allergy, Vol. 2 No. 4 · 2024 · Inggris · DOAJ

Aim: Evaluation of real-world data regarding the use of omalizumab on lung function, asthma control, exacerbations, and oral corticosteroid (OCS). Methods: The single-centre, retrospective study included data from adult patients with severe allergic asthma treated with omalizumab for at least five…

Predictive model to differentiate chronic histaminergic angioedema and chronic spontaneous urticaria with angioedema

Torsten Zuberbier, MD; Ana M. Giménez-Arnau, MD; Marcus Maurer, MD

Journal of Allergy and Clinical Immunology: Global, Vol. 4 No. 2 · 2025 · Inggris · DOAJ Scopus

Short-term Heat Application Reduces Itch Intensity in Atopic Dermatitis: Insights from Mechanical Induction and Real-life Episodes

Joachim W. Fluhr; Leonie Herzog; Razvigor Darlenski dkk.

Acta Dermato-Venereologica, Vol. 104 · 2024 · Inggris · DOAJ Scopus

Heat application is known to activate transient receptor potential (TRP) channels, which play a crucial role in sensory perception, including itch. In this study, the effect of a 5-s, 49°C heat application on itch intensity in atopic dermatitis (AD) patients was evaluated. The study comprised 2…

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells

Zhao Wang; Zhuoran Li; Gürkan Bal dkk.

Frontiers in Allergy, Vol. 3 · 2022 · Inggris · DOAJ Scopus

As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research. Indeed, MRGPRX2 is believed to be a major component of pseudo-allergic reactions to drugs and of neuropeptide-elicited MC…

JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases

Bingrun Li; Xiaoting Song; Cunhao Shan dkk.

Frontiers in Immunology, Vol. 17 · 2026 · Inggris · DOAJ Scopus

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway is involved in the pathogenesis of a variety of inflammatory and autoimmune skin diseases, such as atopic dermatitis (AD), psoriasis, alopecia areata (AA), vitiligo, etc. Many cytokines are involved in…

MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of Gαi, Gαq, Ca++ Channels, ERK1/2 and PI3K—Interconnection between Early and Late Signaling

Zhao Wang; Kristin Franke; Gürkan Bal dkk.

Cells, Vol. 11 No. 6 · 2022 · Inggris · DOAJ Scopus

The recent discovery of MRGPRX2 explains mast cell (MC)-dependent symptoms independently of FcεRI-activation. Because of its novelty, signaling cascades triggered by MRGPRX2 are rudimentarily understood, especially in cutaneous MCs, by which MRGPRX2 is chiefly expressed. Here, MCs purified from…

IL-33 and MRGPRX2-Triggered Activation of Human Skin Mast Cells—Elimination of Receptor Expression on Chronic Exposure, but Reinforced Degranulation on Acute Priming

Zhao Wang; Sven Guhl; Kristin Franke dkk.

Cells, Vol. 8 No. 4 · 2019 · Inggris · DOAJ Scopus

Clinically relevant exocytosis of mast cell (MC) mediators can be triggered by high-affinity IgE receptor (FcεRI)-aggregation (allergic route) or by the so-called pseudo-allergic pathway elicited via MAS-related G protein-coupled receptor-X2 (MRGPRX2). The latter is activated by drugs and…

20 years of the socioeconomic impact of atopic dermatitis and alopecia areata from around the globe

Katarina Stevanovic; Manuel Pereira; Ophélie Nguyen dkk.

Clinical and Translational Allergy, Vol. 15 No. 5 · 2025 · Inggris · DOAJ Scopus

Abstract Atopic dermatitis (AD) and alopecia areata (AA) represent chronic inflammatory diseases characterized by heterogeneous immune‐mediated mechanisms, including subtypes that may interconnect the two diseases, as well as other comorbidities. AD is globally recognized as the most common…