26 hasil untuk "Xiang-Rong Qin"

Helicobacter pylori DNA promotes cellular proliferation, migration, and invasion of gastric cancer by activating toll-like receptor 9

Xiang-Rong Qin; Jia Wu; Xin-Yu Yao dkk.

The Saudi Journal of Gastroenterology, Vol. 25 No. 3 · 2019 · Inggris · DOAJ Scopus

Background/Aim: Helicobacter pylori (H. pylori) infection is a well-known risk factor for gastric cancer. Toll-like receptor 9 (TLR9) plays an important role in many cancers and is important for immunity to H. pylori infection. Thus, the present study aimed to evaluate the influence of H. pylori on…

The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex

Pan-Pan Liu; Shu-Peng Jiang; Bang Li dkk.

PLOS Pathogens, Vol. 21 No. 7 · 2025 · Inggris · PLOS Scopus

Inflammasomes function as immune-signaling platforms that were assembled following detection of pathogens. NLRP1 and CARD8 are related inflammasomes that use their C-terminal (CT) fragments containing a caspase recruitment domain (CARD) and the UPA domain to initiate the inflammasome. At rest…

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Global trends in COVID-19

Chuan-Min Zhou; Xiang-Rong Qin; Li-Na Yan dkk.

Infectious Medicine, Vol. 1 No. 1 · 2022 · Inggris · DOAJ Scopus

The pandemic COVID-19 is certainly one of the most severe infectious diseases in human history. In the last 2 years, the COVID-19 pandemic has caused over 418.6 million confirmed cases and 5.8 million deaths worldwide. Young people make up the majority of all infected COVID-19 cases, but the…

Severe fever with thrombocytopenia syndrome can masquerade as hemorrhagic fever with renal syndrome

Rui Qi; Xiang-rong Qin; Ling Wang dkk.

PLOS Neglected Tropical Diseases, Vol. 13 No. 3 · 2019 · Inggris · PLOS Scopus

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging viral hemorrhagic fever with a high fatality rate and high frequency of person-to-person transmission and is caused by SFTSV, a tick-borne Phlebovirus. Because SFTS has similar clinical manifestations and epidemic…

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Indoor and Outdoor Rodent Hosts of Orientia tsutsugamushi, Shandong Province, China

Fei Li; Zhen-Tang Zhang; Li-Zhu Fang dkk.

Emerging Infectious Diseases, Vol. 27 No. 10 · 2021 · Inggris · DOAJ Scopus

During December 2012–July 2016, we tested small indoor and outdoor mammals in Qingdao, China, for Orientia tsutsugamushi infection. We found that outdoor Apodemus agrarius mice, Cricetulus barabensis hamsters, and Niviventer confucianus rats, as well as indoor Mus musculus mice, tested positive for…

SARS-CoV-2 Delta Variant in Jingmen City, Hubei Province, China, 2021: Children Susceptible and Vaccination Breakthrough Infection

Dan Li; Ai-e Li; Zhu-qing Li dkk.

Frontiers in Microbiology, Vol. 13 · 2022 · Inggris · DOAJ Scopus

BackgroundThe delta variant (B.1.617.2) of SARS-CoV-2 was the dominant viral strain causing COVID-19 in China, 2021. We reported a SARS-CoV-2 delta variant outbreak in Jingmen City, Hubei Province, China.MethodsThe data of epidemiological, clinical, laboratorial, and vaccination of COVID-19 cases…

Reactivation of Epstein-Barr virus in SFTSV infected patients

Li-Zhu Fang; Yu-Hong Dong; Zhi-Jian Yan dkk.

Infectious Medicine, Vol. 2 No. 3 · 2023 · Inggris · DOAJ Scopus

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus SFTSV with case fatality up to 30%. The reactivation of Epstein-Barr virus (EBV) has been proven to occur in individuals with various immune suppression conditions…

Oral and ocular transmission of severe fever with thrombocytopenia syndrome virus

Chuan-Min Zhou; Rui Qi; Xiang-Rong Qin dkk.

Infectious Medicine, Vol. 1 No. 1 · 2022 · Inggris · DOAJ Scopus

Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne bunyavirus that could cause a severe hemorrhagic fever termed SFTS with a high fatality rate of up to 30%. Importantly, SFTSV is frequently transmitted from person-to-person and patients’ blood or excreta are…

Novel Bartonella Species in Insectivorous Bats, Northern China

Hui-Ju Han; Hong-ling Wen; Li Zhao dkk.

PLOS ONE, Vol. 12 No. 1 · 2017 · Inggris · PLOS Scopus

Bartonella species are emerging human pathogens. Bats are known to carry diverse Bartonella species, some of which are capable of infecting humans. However, as the second largest mammalian group by a number of species, the role of bats as the reservoirs of Bartonella species is not fully explored…

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Pathogenic Rickettsia , Anaplasma , and Ehrlichia in Rhipicephalus microplus ticks collected from cattle and laboratory hatched tick larvae

Jiao Xu; Xiao-Lan Gu; Ze-Zheng Jiang dkk.

PLOS Neglected Tropical Diseases, Vol. 17 No. 8 · 2023 · Inggris · PLOS Scopus

Background: The order Rickettsiales contains a group of vector-borne gram-negative obligate intracellular bacteria, which often cause human emerging infectious diseases and economic losses for dairy and meat industries. The purpose of this study is to investigate the distribution of the pathogens…

Emergence of Zika virus infection in China

Chuan-min Zhou; Jian-wei Liu; Rui Qi dkk.

PLOS Neglected Tropical Diseases, Vol. 14 No. 5 · 2020 · Inggris · PLOS Scopus

Currently, Zika virus (ZIKV) is spreading across the world and no ZIKV infection cases have ever been reported in China. Here, we aimed to determine whether ZIKV infection exists in China. Blood samples of 273 healthy individuals were collected from Nanning City, Guangxi Province, China in March…

SFTSV Prevalence in Ticks and Livestock in an SFTSV-Endemic Area in Central China

Hui-Ya Lu; Guan-Du Wu; Meng Peng dkk.

Pathogens, Vol. 14 No. 9 · 2025 · Inggris · DOAJ Scopus

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes a severe viral hemorrhagic fever (SFTS), with a very high case mortality rate, expanding epidemic areas, and increasing incidence. Due to the lack of an effective drug or vaccine for SFTS…

Pair combinations of human monoclonal antibodies fully protected mice against bunyavirus SFTSV lethal challenge

Bang Li; Xiang-rong Qin; Jia-chen Qu dkk.

PLOS Pathogens, Vol. 21 No. 1 · 2025 · Inggris · PLOS Scopus

Severe fever with thrombocytopenia syndrome (SFTS) is a viral hemorrhagic fever caused by a tick-borne virus SFTSV with a mortality rate of up to 30%. Currently, there is no vaccine or effective therapy for SFTS. Neutralizing monoclonal antibody therapy, which provides immediate passive immunity…

Babesia vesperuginis in insectivorous bats from China

Hui-Ju Han; Jian-Wei Liu; Hong-Ling Wen dkk.

Parasites & Vectors, Vol. 11 No. 1 · 2018 · Inggris · DOAJ Scopus

Abstract Background To increase understanding of human bacterial and parasitic pathogens in bats, we investigated the prevalence of Babesia spp., Rickettsia spp., Anaplasma spp. and Coxiella burnetii in bats from China. Methods Bats were captured from Mengyin County, Shandong Province of China…

Molecular identification and phylogenetic analysis of Cryptosporidium, Hepatozoon and Spirometra in snakes from central China

Xiao Xiao; Rui Qi; Hui-Ju Han dkk.

International Journal for Parasitology: Parasites and Wildlife, Vol. 10 · 2019 · Inggris · DOAJ Scopus

Snakes are popular as food and traditional medicine in China. However, information about parasitic and bacterial infections in snakes from China is scarce. We investigated the prevalence of selected zoonotic agents including Cryptosporidium, Hepatozoon and Spirometra, in snakes in central China…

Pathogenic New World Relapsing Fever Borrelia in a Myotis Bat, Eastern China, 2015

Hui-Ju Han; Jian-Wei Liu; Hong-Ling Wen dkk.

Emerging Infectious Diseases, Vol. 26 No. 12 · 2020 · Inggris · DOAJ Scopus

We identified Candidatus Borrelia fainii, a human pathogenic bacterium causing New World relapsing fever in a Myotis bat in eastern China. This finding expands knowledge about the geographic distribution of Borrelia spp. and the potential for infection with New World relapsing fever in China.