7 results for "Yaping An"

Comparison of cardiovascular disease risk association with metabolic unhealthy obesity identified by body fat percentage and body mass index: Results from the 1999–2020 National Health and Nutrition Examination Survey

Qian Xiong; Yang Zhang; Jun Li et al.

PLOS ONE, Vol. 19 No. 8 · 2024 · English · PLOS Scopus

Background and aim: Cardiovascular disease (CVD) risk among individuals across different categories of metabolic obesity phenotypes is controversial. The study used body fat percentage (BFP) or body mass index (BMI) to categorize obese status and to investigate the association between metabolic…

Also available at: DOAJ

Gut microbiota in post-acute COVID-19 syndrome: not the end of the story

Yaping An; Linlin He; Xin Xu et al.

Frontiers in Microbiology, Vol. 15 · 2024 · English · DOAJ Scopus

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to major global health concern. However, the focus on immediate effects was assumed as the tip of iceberg due to the symptoms following acute infection, which was defined as…

Fecal microbiota transplantation: no longer cinderella in tumour immunotherapy

Yunwei Yang; Yaping An; Yue Dong et al.

EBioMedicine, Vol. 100 · 2024 · English · DOAJ Scopus

Summary: The incidence of cancer has shown a great increase during the past decades and poses tough challenges to cancer treatment. Anti-tumour immunotherapy, represented by immune checkpoint inhibitors (ICIs), possesses favorable remission in unrestricted spectrum of cancer types. However, its…

Gut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges

Wanru Zhang; Yaping An; Xiali Qin et al.

Frontiers in Oncology, Vol. 11 · 2021 · English · DOAJ Scopus

Accumulating evidence from studies in humans and animal models has elucidated that gut microbiota, acting as a complex ecosystem, contributes critically to colorectal cancer (CRC). The potential mechanisms often reported emphasize the vital role of carcinogenic activities of specific pathogens, but…

Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis

Yaping An; Zihan Zhai; Xin Wang et al.

Journal of Advanced Research, Vol. 52 · 2023 · English · DOAJ Scopus

…NAIP/NLRC4 inflammasome activation. Furthermore, eugeniin was screened as an inhibitor of the interface between DVF and NAIP and successfully alleviated the proinflammatory effect of DVF in colitis. Conclusion: Targeting DVF-induced NAIP/NLRC4 inflammasome activation and macrophage pyroptosis…

Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis

Yaping An; Hu Zhang; Ling Ba et al.

Cell Reports, Vol. 45 No. 8 · 2026 · English · DOAJ Scopus

…mechanisms of certain metabolites remain ambiguous. Here, we revealed an impaired bile acid homeostasis in UC with a significant deficiency of hyodeoxycholic acid (HDCA), which was inversely correlated with the severity of UC. Ruminococcus callidus was linked to altered HDCA generation, and…