11 hasil untuk "Young-Rae Lee"

Adrenal Vein Sampling in Primary Aldosteronism: A Pictorial Essay for Optimal Left-Side Sampling

Gi Joo Kim; Myung Sub Kim; Hyun Pyo Hong dkk.

Journal of the Korean Society of Radiology, Vol. 84 No. 2 · 2023 · Korea · DOAJ Scopus

Primary aldosteronism (PA) is a curable cause of hypertension. Recent studies have revealed that the actual prevalence of PA is higher than previously recognized. Adrenal vein sampling (AVS) is an essential diagnostic procedure for revealing the cause of PA and determining the treatment plan. The…

Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells

On-Yu Hong; Hye-Yeon Jang; Young-Rae Lee dkk.

Scientific Reports, Vol. 12 No. 1 · 2022 · Inggris · DOAJ Scopus

Abstract Sirtuin 6 (SIRT6) regulation is involved in carcinogenesis. However, its role in breast cancer (BC) metastasis remains unclear. We investigated the effects of SIRT6 on protein kinase C activator- and cytokine-mediated cancer cell invasion and migration in MCF-7 and MDA-MB-231 cells and the…

Termination of Pregnancy Following Periconception Isotretinoin Exposure in South Korea

Young-Rae Lee; Dong-Won Hwang; Kyoung-Chul Chun dkk.

Clinical and Experimental Obstetrics & Gynecology, Vol. 51 No. 6 · 2024 · Inggris · DOAJ Scopus

Background: Despite South Korea’s Ministry of Food and Drug Safety (MFDS) risk management program (RMP) since June 2019, isotretinoin prescriptions have surged 2.5 times from 0.39 million in 2017 to 0.97 million in 2021. This study assesses pregnancy termination risk perception and termination…

Immuno-enhancement effects of Platycodon grandiflorum extracts in splenocytes and a cyclophosphamide-induced immunosuppressed rat model

Eun-Mi Noh; Jeong-Mi Kim; Hak Yong Lee dkk.

BMC Complementary and Alternative Medicine, Vol. 19 No. 1 · 2019 · Inggris · DOAJ

Abstract Background Platycodon grandiflorum is a flowering plant that is used in traditional medicine for treating pulmonary and respiratory disorders. It exerts various pharmacological effects, including immunomodulatory and anti-cancer activities. The purpose of this study was to confirm the in…

Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9

Bo-Mi Hwang; Hee Suk Chae; Young-Ju Jeong dkk.

BMB Reports, Vol. 46 No. 11 · 2013 · Inggris · DOAJ Scopus

The expression of matrix metalloproteinases (MMPs) produced bycancer cells has been associated with the high potential ofmetastasis in several human carcinomas, including breast cancer.Several pieces of evidence demonstrate that protein tyrosinephosphatases (PTP) have functions that promote cell…

Erratum to: Sophorae Flos extract inhibits RANKL-induced osteoclast differentiation by suppressing the NF-κB/NFATc1 pathway in mouse bone marrow cells

Jeong-Mi Kim; Jung-Han Lee; Guem-San Lee dkk.

BMC Complementary and Alternative Medicine, Vol. 17 No. 1 · 2017 · Inggris · DOAJ

Sulforaphane controls TPA-induced MMP-9 expression through the NF-κB signaling pathway, but not AP-1, in MCF-7 breast cancer cells

Young-Rae Lee; Eun-Mi Noh; Ji-Hey Han dkk.

BMB Reports, Vol. 46 No. 4 · 2013 · Inggris · DOAJ Scopus

Sulforaphane [1-isothiocyanato-4-(methylsulfinyl)-butane] is anisothiocyanate found in some cruciferous vegetables, especiallybroccoli. Sulforaphane has been shown to displayanti-cancer properties against various cancer cell lines. Matrixmetalloproteinase-9 (MMP-9), which degrades the…

Myeloid deletion of SIRT1 aggravates serum transfer arthritis in mice via nuclear factor-κB activation.

Young-Sool Hah; Yun-Hong Cheon; Hye Song Lim dkk.

PLoS ONE, Vol. 9 No. 2 · 2014 · Inggris · DOAJ Scopus

OBJECTIVE: SIRT1 modulates the acetylation of the p65 subunit of nuclear factor-κB (NF-κB) and plays a pivotal role in the inflammatory response. This study sought to assess the role of SIRT1 in rheumatoid arthritis (RA) using a myeloid cell-specific SIRT1 knockout (mSIRT1 KO) mouse. METHODS…

NAADP Mediates Insulin-Stimulated Glucose Uptake and Insulin Sensitization by PPARγ in Adipocytes

Eun-Kyung Song; Young-Rae Lee; Yu-Ri Kim dkk.

Cell Reports, Vol. 2 No. 6 · 2012 · Inggris · DOAJ Scopus

Insulin stimulates glucose uptake through the membrane translocation of GLUT4 and GLUT1. Peroxisome proliferator-activated receptor γ (PPARγ) enhances insulin sensitivity. Here, we demonstrate that insulin stimulates GLUT4 and GLUT1 translocation, and glucose uptake, by activating the signaling…

Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats

Young Mi Park; Hak Yong Lee; Yang Gyu Kang dkk.

Food and Agricultural Immunology, Vol. 30 No. 1 · 2019 · Inggris · DOAJ Scopus

Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an…

Immunostimulatory Activity of Black Rice Bran in Cyclophosphamide-Induced Immunosuppressed Rats

Young Mi Park; Hak Yong Lee; Dong Yeop Shin dkk.

Natural Product Communications, Vol. 15 · 2020 · Inggris · DOAJ Scopus

Black rice bran extract (BRBE), containing various biologically active compounds, such as anthocyanin, has antioxidant activity and numerous pharmacological effects. Here, we aimed to confirm the immunostimulatory effects of BRBE in cyclophosphamide (CP)-induced immunosuppressed cells. Our results…