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Lorlatinib Versus Crizotinib in Patients With Advanced ALK -Positive Non–Small Cell Lung Cancer: 5-Year Outcomes From the Phase III CROWN Study
PURPOSE Lorlatinib improved progression-free survival (PFS) and intracranial activity versus crizotinib in patients with previously untreated, advanced, ALK -positive non–small cell lung cancer (NSCLC) in the phase III CROWN study. Here, we report long-term outcomes from CROWN after 5 years of…
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Metabolic regulation of the immune system in health and diseases: mechanisms and interventions
Metabolism, including glycolysis, oxidative phosphorylation, fatty acid oxidation, and other metabolic pathways, impacts the phenotypes and functions of immune cells. The metabolic regulation of the immune system is important in the pathogenesis and progression of numerous diseases, such as…
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Purposive sampling in qualitative research: a framework for the entire journey
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The pathophysiology of sepsis and precision-medicine-based immunotherapy
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Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2
Abstract Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used ‘omic” assays and serology to deeply characterize the global and SARS-CoV-2-specific immunity in the blood of…
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Hydrogel dressings with intrinsic antibiofilm and antioxidative dual functionalities accelerate infected diabetic wound healing
Chronic wounds are often infected with biofilm bacteria and characterized by high oxidative stress. Current dressings that promote chronic wound healing either require additional processes such as photothermal irradiation or leave behind gross amounts of undesirable residues. We report a…
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Mechanisms of sex differences in Alzheimer’s disease
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are complex and multifactorial. The higher AD risk in women may serve as a clue to better understand these complicated processes. In this review, we examine aspects of AD that demonstrate sex-dependent effects and…
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Renal Cell Carcinoma
Importance: Renal cell carcinoma (RCC) is a common malignancy, with an estimated 434 840 incident cases worldwide in 2022. In the US, it is the sixth most common cancer among males and ninth among females. Observations: Clear cell RCC is the most common histologic subtype (75%-80% of cases) and is…
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CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
In the past decade, chimeric antigen receptor (CAR)-T cell therapy has emerged as a promising immunotherapeutic approach for combating cancers, demonstrating remarkable efficacy in relapsed/refractory hematological malignancies in both pediatric and adult patients. CAR-natural killer (CAR-NK) cell…
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JADES
Spectroscopy with the James Webb Space Telescope has opened the possibility of identifying moderate-luminosity active galactic nuclei (AGNs) in the early Universe, at and beyond the epoch of re-ionisation, complementing previous surveys of much more luminous (and much rarer) quasars. We present 12…
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Talking about Large Language Models
Interacting with a contemporary LLM-based conversational agent can create an illusion of being in the presence of a thinking creature. Yet, in their very nature, such systems are fundamentally not like us.
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Abstract RAS oncogenes (collectively NRAS , HRAS and especially KRAS ) are among the most frequently mutated genes in cancer, with common driver mutations occurring at codons 12, 13 and 61 1 . Small molecule inhibitors of the KRAS(G12C) oncoprotein have demonstrated clinical efficacy in patients…
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Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults: Réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : Mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes
BACKGROUND: The Canadian Network for Mood and Anxiety Treatments (CANMAT) last published clinical guidelines for the management of major depressive disorder (MDD) in 2016. Owing to advances in the field, an update was needed to incorporate new evidence and provide new and revised recommendations…
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Guidelines for minimal information on cellular senescence experimentation in vivo
Cellular senescence is a cell fate triggered in response to stress and is characterized by stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging from tissue repair to chronic disease. The development of new tools to study senescence in vivo has paved the way…
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Global burden of cancer and associated risk factors in 204 countries and territories, 1980–2021: a systematic analysis for the GBD 2021
BACKGROUND: Cancer is the second most common cause of death globally. Therefore, it is imperative to investigate cancer incidence, mortality rates, and disability-adjusted life years (DALYs) to enhance preventive measures and healthcare resource allocation. This study aimed to assess cancer burden…
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RETRACTED: Nanotechnology-enhanced fiber-reinforced polymer composites: Recent advancements on processing techniques and applications
Incorporating nanoparticles can significantly improve the performance and functionality of fiber-reinforced polymer (FRP) composites. Different techniques exist for processing, testing, and implementing nanocomposites in various industries. Depending on these factors, these materials can be…
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Healthcare on the brink: navigating the challenges of an aging society in the United States
The US healthcare system is at a crossroads. With an aging population requiring more care and a strained system facing workforce shortages, capacity issues, and fragmentation, innovative solutions and policy reforms are needed. This paper aims to spark dialogue and collaboration among healthcare…
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Language Difference in Writing: Toward a Translingual Approach
Growing numbers of U.S. teachers and scholars of writing recognize that traditional ways of understanding and responding to language differences are inadequate to the facts on the ground. Language use in our classrooms, our communities, the nation, and the world has always been multilingual rather…
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