40,148 results
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The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death
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WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics
Enrichment analysis, crucial for interpreting genomic, transcriptomic, and proteomic data, is expanding into metabolomics. Furthermore, there is a rising demand for integrated enrichment analysis that combines data from different studies and omics platforms, as seen in meta-analysis and multi-omics…
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6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes—2025
The American Diabetes Association (ADA) "Standards of Care in Diabetes" includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA…
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Transparency and accountability in AI systems: safeguarding wellbeing in the age of algorithmic decision-making
The rapid integration of artificial intelligence (AI) systems into various domains has raised concerns about their impact on individual and societal wellbeing, particularly due to the lack of transparency and accountability in their decision-making processes. This review aims to provide an overview…
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Highly accurate blood test for Alzheimer’s disease is similar or superior to clinical cerebrospinal fluid tests
With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. In this study, we evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting…
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Zambian Consumers and the Country-of-Origin Effect
Since increase in exportsis highlybeneficial for the economic development and growth of a country, this research exposes the negative effects of a brand’s country-of-origin on consumer purchase intention in developing countries, it exposes how a brand’s country- of-origin in developing countries…
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Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis
The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo differentiation into osteoblasts. This differentiation process plays a crucial role in bone formation and homeostasis and is regulated by two intricate processes: cell signal transduction and transcriptional gene…
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Social support and mental health: the mediating role of perceived stress
Social support has been associated with improved mental health; however, the mechanisms underlying this relationship remain unclear. This study aimed to explore whether perceived stress mediate the relationship between social support and positive affect, anxiety, and depression. Drawing from…
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In search of artificial intelligence (AI) literacy in teacher education: A scoping review
Artificial Intelligence (AI) literacy has recently emerged on the educational agenda raising expectations on teachers’ and teacher educators’ professional knowledge. This scoping review examines how the scientific literature conceptualises AI literacy in relation to teachers’ different forms of…
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Intraventricular CARv3-TEAM-E T Cells in Recurrent Glioblastoma
In this first-in-human, investigator-initiated, open-label study, three participants with recurrent glioblastoma were treated with CARv3-TEAM-E T cells, which are chimeric antigen receptor (CAR) T cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-specific…
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Soil salinization in agriculture: Mitigation and adaptation strategies combining nature-based solutions and bioengineering
Soil salinization is among the most critical threats to agriculture and food security. Excess of salts adversely affects soil structure and fertility, plant growth, crop yield, and microorganisms. It is caused by natural processes, such as dry climates and low precipitations, high evaporation rate…
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FlyBase: updates to the Drosophila genes and genomes database
FlyBase (flybase.org) is a model organism database and knowledge base about Drosophila melanogaster, commonly known as the fruit fly. Researchers from around the world rely on the genetic, genomic, and functional information available in FlyBase, as well as its tools to view and interrogate these…
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Collaborative Networks: Integrating Blockchain for Enhanced Trust and Transparency
Blockchain technology has become a disruptive force in many different industries because it provides unparalleled security, transparency, and efficiency. In the context of cooperative networks, Blockchain's decentralized architecture provides a solid basis for enhancing trust, streamlining…
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Implementing Blockchain Technology for Optimized Supply Chain and Enhanced Sustainability
Supply chain efficiency, transparency, and sustainability can be enhanced using blockchain technology. Blockchain enables a company to accurately track raw material origin to finished products, which ensures standard quality and sustainability. Furthermore, blockchain improves partnerships between…
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Unified Grounding Systems for Future Projects to Ensure Public Safety and Improve Performance
This study provides a comprehensive analysis of earthing systems as defined by international standards. It involves the calculation of fault currents and contact voltages, the selection of suitable electrical protection for each system type, and an evaluation of the currently implemented systems…
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Oxidative Stress: The Role of Antioxidant Phytochemicals in the Prevention and Treatment of Diseases
Oxidative stress, characterized by an imbalance favouring oxidants over antioxidants, is a key contributor to the development of various common diseases. Counteracting these oxidants is considered an effective strategy to mitigate the levels of oxidative stress in organisms. Numerous studies have…
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A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
Abstract Fusobacterium nucleatum ( Fn ), a bacterium present in the human oral cavity and rarely found in the lower gastrointestinal tract of healthy individuals 1 , is enriched in human colorectal cancer (CRC) tumours 2–5 . High intratumoural Fn loads are associated with recurrence, metastases and…
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Phylogenomics and the rise of the angiosperms
Abstract Angiosperms are the cornerstone of most terrestrial ecosystems and human livelihoods 1,2 . A robust understanding of angiosperm evolution is required to explain their rise to ecological dominance. So far, the angiosperm tree of life has been determined primarily by means of analyses of the…
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Translation, Cross-Cultural Adaptation, and Validation of Measurement Instruments: A Practical Guideline for Novice Researchers
Cross-cultural validation of self-reported measurement instruments for research is a long and complex process, which involves specific risks of bias that could affect the research process and results. Furthermore, it requires researchers to have a wide range of technical knowledge about the…
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