40,148 results
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A physicochemical-sensing electronic skin for stress response monitoring
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Smart Sensors and Smart Data for Precision Agriculture: A Review
Precision agriculture, driven by the convergence of smart sensors and advanced technologies, has emerged as a transformative force in modern farming practices. The present review synthesizes insights from a multitude of research papers, exploring the dynamic landscape of precision agriculture. The…
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Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care
Importance: An accurate blood test for Alzheimer disease (AD) could streamline the diagnostic workup and treatment of AD. Objective: To prospectively evaluate a clinically available AD blood test in primary care and secondary care using predefined biomarker cutoff values. Design, Setting, and…
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Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer
Extracellular vesicles (EVs), including exosomes, are increasingly recognized as potent mediators of intercellular communication due to their capacity to transport a diverse array of bioactive molecules. They assume vital roles in a wide range of physiological and pathological processes and hold…
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Safety and efficacy of malaria vaccine candidate R21/Matrix-M in African children: a multicentre, double-blind, randomised, phase 3 trial
BACKGROUND: Recently, we found that a new malaria vaccine, R21/Matrix-M, had over 75% efficacy against clinical malaria with seasonal administration in a phase 2b trial in Burkina Faso. Here, we report on safety and efficacy of the vaccine in a phase 3 trial enrolling over 4800 children across four…
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JCVI: A versatile toolkit for comparative genomics analysis
The life cycle of genome builds spans interlocking pillars of assembly, annotation, and comparative genomics to drive biological insights. While tools exist to address each pillar separately, there is a growing need for tools to integrate different pillars of a genome project holistically. For…
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Integrated analysis of public datasets for the discovery and validation of survival-associated genes in solid tumors
(HR = 2.65). In summary, a new integrated database for colon cancer is presented. A colon cancer analysis subsystem was integrated into our Kaplan-Meier plotter that can be used to mine the entire database (https://www.kmplot.com). The portal has the potential to be employed for the identification…
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2023 Focused Update of the 2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Document Reviewers: Rudolf A. de Boer (CPG Review Co-ordinator) (Netherlands), P. Christian Schulze (CPG Review Co-ordinator) (Germany), Elena Arbelo (Spain), Jozef Bartunek (Belgium), Johann Bauersachs (Germany), Michael A. Borger (Germany), Sergio Buccheri (Sweden), Elisabetta Cerbai (Italy)…
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ChatGPT for Robotics: Design Principles and Model Abilities
This paper presents an experimental study regarding the use of OpenAI’s ChatGPT [1] for robotics applications. We outline a strategy that combines design principles for prompt engineering and the creation of a high-level function library which allows ChatGPT to adapt to different robotics tasks…
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2024 Adult Compendium of Physical Activities: A third update of the energy costs of human activities
BACKGROUND: The Compendium of Physical Activities was published in 1993 to improve the comparability of energy expenditure values assigned to self-reported physical activity (PA) across studies. The original version was updated in 2000, and again in 2011, and has been widely used to support PA…
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Rapid and sensitive detection of genome contamination at scale with FCS-GX
Assembled genome sequences are being generated at an exponential rate. Here we present FCS-GX, part of NCBI's Foreign Contamination Screen (FCS) tool suite, optimized to identify and remove contaminant sequences in new genomes. FCS-GX screens most genomes in 0.1-10 min. Testing FCS-GX on…
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Recommender Systems in the Era of Large Language Models (LLMs)
With the prosperity of e-commerce and web applications, Recommender Systems (RecSys) have become an indispensable and important component in our daily lives, providing personalized suggestions that cater to user preferences. While Deep Neural Networks (DNNs) have achieved significant advancements…
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Modified GAPI (MoGAPI) Tool and Software for the Assessment of Method Greenness: Case Studies and Applications
Abstract: The green analytical procedure index (GAPI) has been widely used to assess the greenness of different steps in analytical methodology. In the GAPI index, the different stages of the chemical analysis process are depicted using five pentagrams divided in subsections, labeled green, yellow…
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Macrophage polarization: an important role in inflammatory diseases
Macrophages are crucial cells in the human body’s innate immunity and are engaged in a variety of non-inflammatory reactions. Macrophages can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages and anti-inflammatory M2-type macrophages…
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EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the presence of one or more cardiometabolic risk factor(s) and the absence of harmful alcohol intake. The spectrum of MASLD…
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Promises and challenges of generative artificial intelligence for human learning
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How to Interpret Statistical Models Using marginaleffects for R and Python
The parameters of a statistical model can sometimes be difficult to interpret substantively, especially when that model includes nonlinear components, interactions, or transformations. Analysts who fit such complex models often seek to transform raw parameter estimates into quantities that are…
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Unveiling the mechanisms and challenges of cancer drug resistance
Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer treatment strategies are evolving due to innate and acquired resistance capacity, governed by genetic, epigenetic, proteomic, metabolic, or microenvironmental cues that ultimately enable selected cancer cells to…
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Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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