10 results for "Rong-Rong Lin"
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Journal Article
Early-Onset Parkinson’s Disease and Brain Iron Accumulation Caused by a Novel Homozygous Mutation
DJ-1 mutations are rare causes of autosomal recessive early-onset Parkinson’s disease (AR-EOPD) and relatively rarely reported in the Chinese population. Here, we used the whole-exome sequencing and Sanger sequencing to investigate DJ-1 mutations in the Chinese population and confirmed the…
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Journal Article
A novel homozygous c.257del variant in a Chinese family with Nasu–Hakola disease: A case study and literature review
Nasu–Hakola disease is a rare autosomal recessive disorder characterized by progressive cognitive decline and bone cyst formation and is commonly associated with triggering receptor expressed on myeloid cells 2 ( TREM2 ) variants. Herein, we report a novel TREM2 frameshift variant in a middle-aged…
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Journal Article
Microglial Activation, Tau Pathology, and Neurodegeneration Biomarkers Predict Longitudinal Cognitive Decline in Alzheimer’s Disease Continuum
PurposeBiomarkers used for predicting longitudinal cognitive change in Alzheimer’s disease (AD) continuum are still elusive. Tau pathology, neuroinflammation, and neurodegeneration are the leading candidate predictors. We aimed to determine these three aspects of biomarkers in cerebrospinal fluid…
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Journal Article
Genetic Variants and Clinical Characteristics of Young‐Onset Parkinson's Disease in the Hakka Population of Western Fujian
ABSTRACT Research Objective Young‐onset Parkinson's disease (YOPD), defined by symptom onset at or before 50 years of age, has a strong genetic component. The mutation spectra vary markedly across ethnic groups. However, YOPD among the Hakka, a subgroup of the Han Chinese ethnicity, remains…
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Journal Article
Osteoporosis-mediated exacerbation of the amyloid-β pathology: Involvement of serum calcium
Alzheimer's disease (AD) and osteoporosis (OP) are two common age-related degenerative diseases with similar epidemiological characteristics, yet their complex relationship and specific mechanistic intersections remain unclear. In this study, 775 individuals were divided into OP and non-OP groups…
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Journal Article
A study on UHPLC-MS/MS analyses of DNA and RNA oxidative damage metabolites in patients with cervical carcinoma: 8-oxoG in urine as a potential biomarker of cervical carcinoma
Objective: The purpose of this study was to compare the levels of 8-oxoG and 8-oxodG in urine of patients with cervical carcinoma and healthy women to evaluate their influences on cervical carcinoma. Methods: In this study, urine samples were collected from 70 patients with cervical carcinoma, 24…
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Journal Article
CD2AP deficiency aggravates Alzheimer’s disease phenotypes and pathology through p38 MAPK activation
Abstract Background Alzheimer’s disease (AD) is the most common form of neurodegenerative disorder, which is characterized by a decline in cognitive abilities. Genome-wide association and clinicopathological studies have demonstrated that the CD2-associated protein (CD2AP) gene is one of the most…
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Journal Article
Hybrid Membrane‐Coated Nanoparticles for Precise Targeting and Synergistic Therapy in Alzheimer's Disease
Abstract The blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane‐coated nanoparticles derived from different cell types can mimic the surface properties and functionalities of the source cells, further enhancing their…
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Journal Article
Early Diagnosis of Alzheimer’s Disease: Moving Toward a Blood-Based Biomarkers Era
Qing-Qing Tao,1 Rong-Rong Lin,1 Zhi-Ying Wu1,2 1Department of Neurology and Research Center of Neurology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, People’s Republic of China; 2MOE Frontier Science Center for Brain Science and Brain-Machine…