23 results for "Li-Rong Wang"

Exploiting the similarity of dissimilarities for biomedical applications and enhanced machine learning

Mohammad Neamul Kabir; Li Rong Wang; Wilson Wen Bin Goh

PLOS Computational Biology, Vol. 21 No. 1 · 2025 · English · PLOS Scopus

The “similarity of dissimilarities” is an emerging paradigm in biomedical science with significant implications for protein function prediction, machine learning (ML), and personalized medicine. In protein function prediction, recognizing dissimilarities alongside similarities provides a more…

Also available at: DOAJ

Protocol to identify functional doppelgängers and verify biomedical gene expression data using doppelgangerIdentifier

Li Rong Wang; Xiuyi Fan; Wilson Wen Bin Goh

STAR Protocols, Vol. 3 No. 4 · 2022 · English · DOAJ Scopus

…details on the use and execution of this protocol, please refer to Wang et al. (2022). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Doppelgänger spotting in biomedical gene expression data

Li Rong Wang; Xin Yun Choy; Wilson Wen Bin Goh

iScience, Vol. 25 No. 8 · 2022 · English · DOAJ Scopus

Summary: Doppelgänger effects (DEs) occur when samples exhibit chance similarities such that, when split across training and validation sets, inflates the trained machine learning (ML) model performance. This inflationary effect causes misleading confidence on the deployability of the model. Thus…

Identification of the regulatory networks and hub genes controlling alfalfa floral pigmentation variation using RNA-sequencing analysis

Hui-Rong Duan; Li-Rong Wang; Guang-Xin Cui et al.

BMC Plant Biology, Vol. 20 No. 1 · 2020 · English · DOAJ Scopus

Abstract Background To understand the gene expression networks controlling flower color formation in alfalfa, flowers anthocyanins were identified using two materials with contrasting flower colors, namely Defu and Zhongtian No. 3, and transcriptome analyses of PacBio full-length sequencing…

Aligning deep learning and interpretable models for blood cell classification: A dual-model framework for explainability

Magdalene Yeok Yu Cheong; Xinran Xu; Li Rong Wang et al.

PLOS Digital Health, Vol. 5 No. 7 · 2026 · English · PLOS Scopus

Blood smear examination involves classifying cells by morphology under a microscope, a labour-intensive process prone to subjective variation. Recent deep learning models achieve strong performance in blood cell classification but remain as “black boxes”, offering little clinical transparency. We…

Accumulated chilling hours during endodormancy impact blooming and fruit shape development in peach (Prunus persica L.)

Yong LI; Wei-chao FANG; Geng-rui ZHU et al.

Journal of Integrative Agriculture, Vol. 15 No. 6 · 2016 · English · DOAJ Scopus

Winter chill is essential for the growth and development of deciduous species. To understand the relationship between accumulated chilling hours during endodormancy and blooming and fruit shape development, we controlled chilling hours and investigated their effects on blooming date and fruit shape…

The first case of Francisella novicida infection in Taiwan: bacteraemic pneumonia in a haemodialysis adult

Hao-En Jan; Chin-Shiang Tsai; Nan-Yao Lee et al.

Emerging Microbes and Infections, Vol. 11 No. 1 · 2022 · English · DOAJ Scopus

Tularaemia is a zoonotic disease caused by Francisella tularensis (F. tularensis). Human infection is rare and can be life-threatening. F. tularensis subsp. novicida used to be a subspecies of F. tularensis, is now considered a different species, F. novicida. Though less virulent, F. novicida can…

Moderate Dose of Trolox Preventing the Deleterious Effects of Wi-Fi Radiation on Spermatozoa In vitro through Reduction of Oxidative Stress Damage

Shang-Shu Ding; Ping Sun; Zhou Zhang et al.

Chinese Medical Journal, Vol. 131 No. 4 · 2018 · English · DOAJ Scopus

Background: The worsening of semen quality, due to the application of Wi-Fi, can be ameliorated by Vitamin E. This study aimed to demonstrate whether a moderate dose of trolox, a new Vitamin E, inhibits oxidative damage on sperms in vitro after exposure to Wi-Fi radiation. Methods: Each of the…

Melioidosis Outbreak after Typhoon, Southern Taiwan

Wen-Chien Ko; Bruno Man-Hon Cheung; Hung-Jen Tang et al.

Emerging Infectious Diseases, Vol. 13 No. 6 · 2007 · English · DOAJ Scopus

From July through September 2005, shortly after a typhoon, 40 cases of Burkholderia pseudomallei infection (melioidosis) were identified in southern Taiwan. Two genotypes that had been present in 2000 were identified by pulsed-field gel electrophoresis. Such a case cluster confirms that melioidosis…

Germplasm and molecular breeding in horticultural crops

Jun WU, Prof.; Qing-mei GUAN, Prof.; Li-rong WANG, Prof. et al.

Journal of Integrative Agriculture, Vol. 22 No. 11 · 2023 · English · DOAJ Scopus

The predictive role of systemic immune-inflammation index on futile recanalization in acute ischemic stroke with mechanical thrombectomy

Huan Liu; Ying-Jie Li; Li-Jun Jia et al.

World Neurosurgery: X, Vol. 28 · 2025 · English · DOAJ Scopus

Background and purpose: Futile recanalization (FR) occurs in patients who achieve successful vessel recanalization but still have a poor prognosis. The aim of this study was to explore the association between systemic immune-inflammation index (SII) and futile recanalization following mechanical…

Predictors of futile recanalization after endovascular treatment of acute ischemic stroke

Li-Rong Wang; Bing-Hu Li; Qi Zhang et al.

BMC Neurology, Vol. 24 No. 1 · 2024 · English · DOAJ Scopus

Abstract Objective Endovascular therapy (EVT) is the most successful treatment for patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) in the anterior circulation. However, futile recanalization (FR) seriously affects the prognosis of these patients. The aim of this study…

Association of free fatty acid receptor 2 expression in peripheral blood monocytes with carotid atherosclerosis

Li-Jun Jia; Li-Rong Wang; Sen Zhou et al.

European Journal of Medical Research, Vol. 30 No. 1 · 2025 · English · DOAJ Dropped by Scopus 2024

Abstract Purpose To investigate the relationship between free fatty acid receptor 2 (FFAR2) expression in peripheral blood monocytes and carotid atherosclerosis (CAS). Methods Between November 2023 and June 2024, individuals who underwent carotid ultrasound in the inpatient or outpatient settings…

Legionnaires' disease at a medical center in southern Taiwan

Tzu-Lun Hung; Ming-Chi Li; Li-Rong Wang et al.

Journal of Microbiology, Immunology and Infection, Vol. 51 No. 3 · 2018 · English · DOAJ Scopus

Background/purpose: Legionella pneumophila had been recognized as a pathogen for both healthcare-associated and community-acquired pneumonia. We aimed to evaluate clinical features and outcomes of patients with Legionnaires' disease at a tertiary medical center in southern Taiwan. Methods: From…

Mechanism of human chorionic gonadotropin in endometrial receptivity via the miR‐126‐3p/PI3K/Akt/eNOS axis

Wei Wang; Liang Ge; Li‐Li Zhang et al.

Kaohsiung Journal of Medical Sciences, Vol. 39 No. 5 · 2023 · English · DOAJ Scopus

Abstract Human chorionic gonadotropin (hCG) might affect endometrial receptivity, exerting integral roles in embryo implantation. This study explored the action of hCG in endometrial receptivity via the miR‐126‐3p/PIK3R2/PI3K/Akt/eNOS axis. The embryo implantation dysfunction (EID) mouse models…

Development and evaluation of an elisa system for detection of pedv-specific iga antibodies in colostrum

Ren-Feng LI; Xiang-Qin TIAN; Yan YU et al.

Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol. 24 No. 5 · 2018 · English · DOAJ Scopus

Porcine epidemic diarrhea virus (PEDV) is a devastating swine infectious disease. Development of high-performance methods to diagnose and evaluate viral immune status remains very important to control PEDV. Here, a recombinant S1 protein-based indirect enzyme-linked immunosorbent assay…

Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke

Xu-Dong Cheng; Duo-Zi Wang; Qi Zhang et al.

BMC Neurology, Vol. 23 No. 1 · 2023 · English · DOAJ Scopus

Abstract Purpose To investigate the predictive role of pre-thrombolytic high sensitivity C-reactive protein (hs-CRP) on the safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods Patients with AIS who underwent intravenous thrombolysis with recombinant…

Evaluating Chain-of-Thought reasoning in large language models for thyroid ultrasound interpretation: a dual-information approach

Yu-Tong Zhang; Si-Yi Wu; Dong Zhang et al.

Frontiers in Artificial Intelligence, Vol. 9 · 2026 · English · DOAJ Scopus

ObjectiveTo assess whether reasoning-capable large language models (LLMs) can accurately interpret both qualitative and quantitatively encoded ultrasound features of thyroid nodules within the ACR-TIRADS framework and improve diagnostic reliability.MethodsThis retrospective study analyzed thyroid…

A Competency Framework for Medical AI Education: Mixed Methods Study

Chang Cai; Gaoxia Zhu; Shang-Ming Zhou et al.

JMIR Medical Education, Vol. 12 · 2026 · English · DOAJ Scopus

Abstract BackgroundAlthough artificial intelligence (AI) is increasingly adopted in health care, clinicians face barriers, including insufficient understanding, limited trust, and challenges in interpreting AI outputs. Existing frameworks, such as the United Nations Educational, Scientific and…