33 results for "Li-Lin Du"

Global analysis of fission yeast mating genes reveals new autophagy factors.

Ling-Ling Sun; Ming Li; Fang Suo et al.

PLoS Genetics, Vol. 9 No. 8 · 2013 · English · DOAJ Scopus

Macroautophagy (autophagy) is crucial for cell survival during starvation and plays important roles in animal development and human diseases. Molecular understanding of autophagy has mainly come from the budding yeast Saccharomyces cerevisiae, and it remains unclear to what extent the mechanisms…

Lipidation-independent vacuolar functions of Atg8 rely on its noncanonical interaction with a vacuole membrane protein

Xiao-Man Liu; Akinori Yamasaki; Xiao-Min Du et al.

eLife, Vol. 7 · 2018 · English · DOAJ

The ubiquitin-like protein Atg8, in its lipidated form, plays central roles in autophagy. Yet, remarkably, Atg8 also carries out lipidation-independent functions in non-autophagic processes. How Atg8 performs its moonlighting roles is unclear. Here we report that in the fission yeast…

Fission Yeast Pxd1 Promotes Proper DNA Repair by Activating Rad16 XPF and Inhibiting Dna2

Jia-Min Zhang; Xiao-Man Liu; Yue-He Ding et al.

PLoS Biology, Vol. 12 No. 9 · 2014 · English · PLOS Scopus

: During DNA double-strand break repair, two structure-specific DNA nucleases are controlled by the same regulator Pxd1, but in opposite manners. Structure-specific nucleases play crucial roles in many DNA repair pathways. They must be precisely controlled to ensure optimal repair outcomes…

Also available at: DOAJ

The ortholog of human REEP1-4 is required for autophagosomal enclosure of ER-phagy/nucleophagy cargos in fission yeast.

Chen-Xi Zou; Zhu-Hui Ma; Zhao-Di Jiang et al.

PLoS Biology, Vol. 21 No. 11 · 2023 · English · DOAJ Scopus

Selective macroautophagy of the endoplasmic reticulum (ER) and the nucleus, known as ER-phagy and nucleophagy, respectively, are processes whose mechanisms remain inadequately understood. Through an imaging-based screen, we find that in the fission yeast Schizosaccharomyces pombe, Yep1 (also known…

The wtf meiotic driver gene family has unexpectedly persisted for over 100 million years

Mickaël De Carvalho; Guo-Song Jia; Ananya Nidamangala Srinivasa et al.

eLife, Vol. 11 · 2022 · English · DOAJ

Meiotic drivers are selfish elements that bias their own transmission into more than half of the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought to exist for relatively short evolutionary timespans because a driver gene or gene family is often found in a…

Slx5p‐Slx8p Promotes Accurate Chromosome Segregation by Mediating the Degradation of Synaptonemal Complex Components during Meiosis

Chao Liu; Haichao Zhao; Sai Xiao et al.

Advanced Science, Vol. 7 No. 4 · 2020 · English · DOAJ Scopus

Abstract Meiosis increases genetic diversity, yet the genome complement needs to be stable to ensure offspring viability. Both small ubiquitin‐like modifier (SUMO) and ubiquitin have been reported to participate in meiotic regulation, yet functions of the SUMO‐ubiquitination crosstalk in meiosis…

Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers

Jin-Xin Zheng; Tong-Yang Du; Guang-Can Shao et al.

Nature Communications, Vol. 14 No. 1 · 2023 · English · DOAJ Scopus

Abstract Killer meiotic drivers (KMDs) skew allele transmission in their favor by killing meiotic progeny not inheriting the driver allele. Despite their widespread presence in eukaryotes, the molecular mechanisms behind their selfish behavior are poorly understood. In several fission yeast…

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

Zhu-Hui Ma; Zhao-Qian Pan; Zhao-Di Jiang et al.

Nature Communications, Vol. 17 No. 1 · 2026 · English · DOAJ Scopus

Abstract Selective autophagy of the nucleus, known as nucleophagy, targets nuclear components for degradation. The molecular mechanisms underlying nucleophagy remain inadequately understood. In this study, we identify a nucleophagy receptor, Npr1, in the fission yeast Schizosaccharomyces pombe…

Mck1 defines a key S-phase checkpoint effector in response to various degrees of replication threats.

Xiaoli Li; Xuejiao Jin; Sushma Sharma et al.

PLoS Genetics, Vol. 15 No. 8 · 2019 · English · DOAJ Scopus

The S-phase checkpoint plays an essential role in regulation of the ribonucleotide reductase (RNR) activity to maintain the dNTP pools. How eukaryotic cells respond appropriately to different levels of replication threats remains elusive. Here, we have identified that a conserved GSK-3 kinase Mck1…

Systematic analysis reveals the prevalence and principles of bypassable gene essentiality

Jun Li; Hai-Tao Wang; Wei-Tao Wang et al.

Nature Communications, Vol. 10 No. 1 · 2019 · English · DOAJ Scopus

An essential gene may become non-essential when another gene is mutated. Here, the authors investigate this type of digenic interaction, termed ‘bypass of essentiality’, in the fission yeast Schizosaccharomyces pombe, and show that bypassable essential genes are common and share certain features.

Perturbation of kinetochore function using GFP-binding protein in fission yeast

Da-Jie Deng; Qian-Cheng Xia; Guo-Song Jia et al.

G3: Genes, Genomes, Genetics, Vol. 11 No. 11 · 2021 · English · DOAJ Scopus

AbstractUsing genetic mutations to study protein functions in vivoSchizosaccharomyces pombein vivo

S-phase PARylation of microprotein RSMC enhances the function of Sororin in sister chromatid cohesion

Meiqian Jiang; Jiaxin Zhang; Jiankun He et al.

The EMBO Journal, Vol. 45 No. 1 · 2025 · English · DOAJ Scopus

Abstract Sororin is essential for establishing sister chromatid cohesion concurrently with DNA replication in metazoans. Although acetylation of the cohesin subunit SMC3 by ESCO1/2 is necessary for Sororin recruitment, it is by itself not sufficient. Here, we demonstrate that DNA…