33 hasil untuk "Antonio Addis"
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Artikel Jurnal
Place in therapy of olmesartan
Place in therapy of olmesartanOlmesartan has been de-reimbursed in France since January 2017 following a negative evaluation of its benefit/risk profile compared with other sartans. However, olmesartan is one of the antihypertensive blockbusters in Italy in terms of usage and expenditure. This…
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Artikel Jurnal
Palivizumab reimbursement criteria and neonatal RSV hospitalisation: a regional retrospective review
In Italy, reimbursement restrictions regarding palivizumab prophylaxis approved in 2016 have been revoked in 2017, restoring use in infants with Gestational Age (GA) >29 weeks. Respiratory Syncytial Virus (RSV) hospitalisations and prevalence of palivizumab use in infants aged <6 months during five…
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Artikel Jurnal
Price and reimbursement for orphan medicines and managed entry agreements: does Italy need a framework?
This article illustrates a consensus opinion of an expert panel on the need and usefulness of a framework for price and reimbursement (P&R) process and managed entry agreements (MEAs) for orphan medicines in Italy. This opinion was gathered in three rounds: an introductory document was sent to the…
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Polytherapy and Multimorbidity Pattern of Users of Anti-VEGF Drugs and Dexamethasone for the Treatment of Age-Related Macular Degeneration and other Vascular Retinopathies in Clinical Practice
Introduction: Our aim was to describe the polytherapy and multimorbidity pattern of users of anti-VEGF and dexamethasone drugs for the treatment of these conditions, and to investigate their polytherapy and multimorbidity profiles, together with adherence and the burden of care. Methods…
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Artikel Jurnal
Drug Prescriptions in the Outpatient Management of COVID-19: Evidence-Based Recommendations Versus Real Practice
Background: Evidence-based recommendations for outpatient management of COVID-19 were published by the Italian Medicines Agency (AIFA) to limit the use of off-label treatments. The aim of this study is to measure the use of outpatient drug treatments in a COVID-19-positive population, taking into…
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Artikel Jurnal Teks lengkap
Using Clinical Evidence in a National Continuing Medical Education Program in Italy
In an effort to ensure that physicians have access to reliable evidence on drug effectiveness and safety, the Italian Drug Agency launched a program to disseminate independent information.
Juga tersedia di: DOAJ
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Artikel Jurnal
An epidemiological investigation of high-risk infants for Respiratory Syncytial Virus infections: a retrospective cohort study
Abstract Background Respiratory Syncytial Virus (RSV) infections may lead to severe consequences in infants born preterm with breathing problems (such as bronchopulmonary dysplasia (BPD) and respiratory distress syndrome (RDS)) or congenital heart diseases (CHD). Since studies investigating the…
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Artikel Jurnal
Real-world antibiotic utilization during pregnancy in Italy: a multiregional retrospective population-based study
Abstract Background Exposure to antibiotics during pregnancy is frequent, despite the limited evidence derived from clinical trials. Drug utilization studies could improve knowledge on utilization of these medications during this critical period. In this context, the present study aimed to describe…
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Artikel Jurnal
Investigating socioeconomic disparities in lung cancer diagnosis, treatment and mortality: an Italian cohort study
Abstract Background Lung cancer is one of the most lethal cancers worldwide and patient clinical outcomes seem influenced by their socioeconomic position (SEP). Since little has been investigated on this topic in the Italian context, our aim was to investigate the role of SEP in the care pathway of…
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Artikel Jurnal
The Standard of Care Definitions on COVID-19 Pharmacological Clinical Trials: A Systematic Review
Background: Standard of Care (SoC) has been used with different significance across Randomized Clinical Trials (RCTs) on the treatment of Covid-19. In the context of a living systematic review on pharmacological interventions for COVID-19, we assessed the characteristics of the SoC adopted in the…
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Artikel Jurnal
Anticancer drug prices and clinical outcomes: a cross-sectional study in Italy
Objective To investigate whether the prices of new anticancer drugs correlated with their relative benefit despite negotiation.Design Retrospective cross-sectional study correlating new anticancer drugs prices with clinical outcomes.Setting We did a retrospective cross-sectional study including all…
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Artikel Jurnal
Drug utilization in patients starting haemodialysis with a focus on cardiovascular and antidiabetic medications: an epidemiological study in the Lazio region (Italy), 2016–2020
Abstract Background Entering dialysis is a critical moment in patients’ healthcare journey, and little is known about drug therapy around it. A study funded by the Italian Medicines Agency offered the opportunity to leverage data from the Lazio Regional Dialysis and Transplant Registry (RRDTL) and…
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Artikel Jurnal
Orphan Drug Prices and Epidemiology of Rare Diseases: A Cross-Sectional Study in Italy in the Years 2014–2019
IntroductionIt is well acknowledged that the price of orphan drugs is normally higher than that resulting from the value-based pricing. A correlation between the cost of therapy for orphan drugs and the epidemiology (prevalence and incidence) of the related rare disease can be…
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Monitoring medicine prescriptions before, during and after pregnancy in Italy
Background: The use of medications during pregnancy is a common event worldwide. Monitoring medicine prescriptions in clinical practice is a necessary step in assessing the impact of therapeutic choices in pregnant women as well as the adherence to clinical guidelines. The aim of this study was to…
Juga tersedia di: DOAJ
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Artikel Jurnal
Development of Approaches and Metrics to Measure the Impact and Improve the Clinical Outcomes of Patients With Frailty in the Era of COVID-19. The COMETA Italian Protocol
The outbreak of the coronavirus 2 disease 2019 (COVID-19) puts an enormous burden on healthcare systems worldwide. This may worsen outcomes in patients with severe chronic diseases such as cancer, autoimmune diseases, and immune deficiencies. In this critical situation, only a few available data…
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Artikel Jurnal
Comparative Effectiveness of Pharmacological Interventions for Covid-19: A Systematic Review and Network Meta-Analysis
Background: Several pharmacological interventions are now under investigation for the treatment of Covid-19, and the evidence is evolving rapidly. Our aim is to assess the comparative efficacy and safety of these drugs.Methods and Findings: We performed a systematic review and network meta-analysis…
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Artikel Jurnal
Potentially inappropriate drug use in myasthenia gravis: a real-world population-based cohort study in Italy
IntroductionTo evaluate the use of pyridostigmine in presence of contraindications, and the use of concomitant potentially contraindicated drugs in a cohort of patients affected by Myasthenia Gravis (MG) in the Italian Regions of Lazio, Tuscany, and Umbria.MethodsThis is a retrospective cohort…