19 hasil untuk "Francesca Rea"
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Artikel Jurnal
Eosinophilic Esophagitis and Microbiota: State of the Art
Eosinophilic esophagitis (EoE) is a chronic, food-triggered, immune-mediated disease of the oesophagus, clinically characterized by symptoms referred to oesophagal dysfunction, and histologically defined by an eosinophil productive inflammation of the oesophagal mucosa, among other cell types. The…
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Erratum in: PedEoEvolution: optimizing pediatric and adolescent eosinophilic esophagitis management in Italy
Juga tersedia di: DOAJ
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Artikel Jurnal
PedEoEvolution: optimizing pediatric and adolescent eosinophilic esophagitis management in Italy
This review addresses the unique challenges of pediatric eosinophilic esophagitis (EoE) management, aiming to develop a comprehensive knowledge base, standardize therapeutic approaches, and explore new targeted biological treatments. A non-systematic literature review was conducted, complemented by…
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Artikel Jurnal
Functional and structural characterization of the human indolethylamine N-methyltransferase through fluorometric, thermal and computational docking analyses
Abstract Background The “psychedelic renaissance” is sparking growing interest in clinical research, along with a rise in clinical trials. Substances such as 3,4-methylenedioxymethamphetamine (MDMA), psilocybin and N,N-dimethyltryptamine (DMT) are involved. The focus of this paper is on…
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Pancreatitis Preceding the Diagnosis of IBD in Children: A Retrospective Observational Study
Background: Pancreatic involvement in inflammatory bowel diseases (IBD) is relatively common and includes a range of conditions, such as acute pancreatitis (AP), chronic pancreatitis (CP), autoimmune pancreatitis (AIP), and pancreatic exocrine insufficiency (PEI). However, pancreatitis as a…
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Artikel Jurnal
Use of gastroscopy in the management of pediatric toxic ingestions: insights from a decade of experience – a retrospective study
ObjectivePediatric poisonings account for a significant proportion of poison center consultations. Gastrointestinal decontamination (GD) is a crucial intervention in cases of acute poisoning, yet its effectiveness remains debated. This study aims to evaluate the role of esophagogastroduodenoscopy…
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Artikel Jurnal
Eosinophilic esophagitis in esophageal atresia: Tertiary care experience of a “selective” approach for biopsy sampling
Background: A high prevalence (9.5–30%) of eosinophilic esophagitis (EoE) in patients with esophageal atresia (EA) has been reported. The application of the EoE criteria to EA patients might be problematic. To date, only studies using a “routine” biopsy approach, even in asymptomatic patients, have…
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Artikel Jurnal
An uncommon cause of abdominal pain in a child: Meckel diverticulum
Meckel diverticulum, a common congenital anomaly of the small intestine, can be responsible of several complications due to the presence of ectopic gastric mucosa and represents a challenge for diagnosis. We present the case of a 11-year boy suffering from intestinal pain and bleeding in which…
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Artikel Jurnal
Anastomotic Strictures after Esophageal Atresia Repair: Incidence, Investigations, and Management, Including Treatment of Refractory and Recurrent Strictures
Improved surgical techniques, as well as preoperative and postoperative care, have dramatically changed survival of children with esophageal atresia (EA) over the last decades. Nowadays, we are increasingly seeing EA patients experiencing significant short- and long-term gastrointestinal…
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Artikel Jurnal
Vernal keratoconjunctivitis and eosinophilic esophagitis: A rare combination?
Vernal keratoconjunctivitis (VKC) is a bilateral ocular inflammatory disease with a conjunctival and corneal involvement and typical onset during childhood. Eosinophilic esophagitis (EoE) is a chronic disease characterized by eosinophilic inflammation of the mucosa (≥15 eosinophils/HPF) and…
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Artikel Jurnal
Bridging eosinophilic esophagitis: healthcare transition from pediatric to adult patients
Abstract Eosinophilic esophagitis (EoE) is a chronic and progressive type 2 immune-mediated disease resulting in esophageal dysfunction. As with other chronic conditions, therapeutic continuity is crucial to ensure patient benefits, particularly during the transition of patients with EoE from…
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Artikel Jurnal
Novel X-Linked Inhibitor of Apoptosis Mutation in Very Early-Onset Inflammatory Bowel Disease Child Successfully Treated with HLA-Haploidentical Hemapoietic Stem Cells Transplant after Removal of αβ+ T and B Cells
Monogenic defects in genes related to primary immunodeficiencies can be responsible for inflammatory bowel disease (IBD). Mutations in the X-linked inhibitor of apoptosis (XIAP) gene have been described in several patients suffering from IBD and, in particular, with very early-onset inflammatory…
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Pharmacokinetic Evaluation of Oral Viscous Budesonide in Paediatric Patients with Eosinophilic Oesophagitis in Repaired Oesophageal Atresia
Eosinophilic oesophagitis is a long-term complication of oesophageal atresia (EA), an uncommon condition that affects approximately 1 in 3500 infants. An exploratory, open-label phase 2 clinical trial was conducted in paediatric eosinophilic oesophagitis after oesophageal atresia (EoE-EA) to assess…
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Artikel Jurnal
Case report: Neonatal-onset inflammatory bowel disease due to novel compound heterozygous mutations in DUOX2
Very Early Onset Inflammatory Bowel Disease (VEO-IBD) is potentially associated with genetic disorders of the intestinal epithelial barrier or inborn errors of immunity (IEI). Dual oxidase 2 (DUOX2), an H2O2-producing NADPH oxidase expressed at apical enterocyte membranes, plays a crucial role in…
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Artikel Jurnal Teks lengkap
Evaluation of Safety and Immunogenicity of BNT162B2 mRNA COVID-19 Vaccine in IBD Pediatric Population with Distinct Immune Suppressive Regimens
Patients affected by Inflammatory Bowel Disease (IBD) present higher risk for infection and suboptimal response upon vaccination. The immunogenicity of SARS-CoV2 vaccination is still largely unknown in adolescents or young adults affected by IBD (pIBD). We investigated the safety and immunogenicity…
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Artikel Jurnal
Eosinophilic esophagitis in children and adolescents: a clinical practice guideline
Abstract Eosinophilic esophagitis (EoE) is a chronic immune-mediated condition that affects the esophagus and is marked by the presence of eosinophils. This disease is becoming more common in children and adolescents and can result in symptoms like swallowing difficulties, food impaction and…